| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,411,021 | 45,809,000 | 17.35% | ||
| 2 | Omega Fund Management, LLC | 2,138,872 | 40,639,000 | 15.39% | ||
| 3 | BAUPOST GROUP LLC/MA | 1,544,498 | 29,345,000 | 11.11% | ||
| 4 | Abingworth LLP | 1,301,413 | 24,701,000 | 9.35% | ||
| 5 | Tekla Capital Management LLC | 762,581 | 14,489,000 | 5.49% | ||
| 6 | Aisling Capital LLC | 682,680 | 12,971,000 | 4.91% | ||
| 7 | Broadfin Capital, LLC | 530,283 | 10,075,000 | 3.82% | ||
| 8 | GREAT POINT PARTNERS LLC | 453,878 | 8,624,000 | 3.27% | ||
| 9 | BROWN BROTHERS HARRIMAN & CO | 367,902 | 6,990,000 | 2.65% | ||
| 10 | Granahan Investment Management, LLC | 340,288 | 6,465,000 | 2.45% | ||
| 11 | VANGUARD GROUP INC | 334,324 | 6,353,000 | 2.41% | ||
| 12 | BlackRock Fund Advisors | 315,878 | 6,002,000 | 2.27% | ||
| 13 | JENNISON ASSOCIATES LLC | 303,048 | 5,758,000 | 2.18% | ||
| 14 | GENERAL AMERICAN INVESTORS CO INC | 277,076 | 5,264,000 | 1.99% | ||
| 15 | Bank of New York Mellon Corp | 229,742 | 4,365,000 | 1.65% | ||
| 16 | JPMORGAN CHASE & CO | 217,017 | 4,123,000 | 1.56% | ||
| 17 | Roumell Asset Management, LLC | 201,845 | 3,835,000 | 1.45% | ||
| 18 | Omega Advisors Inc. | 142,100 | 2,700,000 | 1.02% | ||
| 19 | STATE STREET CORP | 139,165 | 2,645,000 | 1.00% | ||
| 20 | Lombard Odier Asset Management (USA) Corp | 135,710 | 2,578,000 | 0.98% | ||
| 21 | BlackRock Institutional Trust Company, N.A. | 125,535 | 2,385,000 | 0.90% | ||
| 22 | NEA Management Company, LLC | 125,004 | 2,375,000 | 0.90% | ||
| 23 | NORTHERN TRUST CORP | 124,922 | 2,373,000 | 0.90% | ||
| 24 | SABBY MANAGEMENT, LLC | 117,046 | 2,224,000 | 0.84% | ||
| 25 | RENAISSANCE TECHNOLOGIES LLC | 98,813 | 1,877,000 | 0.71% | ||
| 26 | TURNER INVESTMENTS LLC | 52,720 | 1,002,000 | 0.38% | ||
| 27 | DEUTSCHE BANK AG\ | 50,171 | 951,000 | 0.36% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 48,855 | 928,000 | 0.35% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 47,641 | 905,000 | 0.34% | ||
| 30 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 42,660 | 811,000 | 0.31% | ||
| 31 | BlackRock Investment Management, LLC | 41,564 | 790,000 | 0.30% | ||
| 32 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 22,169 | 421,000 | 0.16% | ||
| 33 | NORGES BANK | 21,313 | 405,000 | 0.15% | ||
| 34 | TEACHERS ADVISORS, LLC | 17,609 | 335,000 | 0.13% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 17,408 | 331,000 | 0.13% | ||
| 36 | Weiss Multi-Strategy Advisers LLC | 15,000 | 285,000 | 0.11% | ||
| 37 | NEW YORK STATE COMMON RETIREMENT FUND | 11,700 | 222,000 | 0.08% | ||
| 38 | RHUMBLINE ADVISERS | 10,407 | 198,000 | 0.07% | ||
| 39 | APPLETON PARTNERS INC/MA | 10,109 | 192,000 | 0.07% | ||
| 40 | METROPOLITAN LIFE INSURANCE CO/NY | 9,202 | 175,000 | 0.07% | ||
| 41 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 8,452 | 161,000 | 0.06% | ||
| 42 | Nationwide Fund Advisors | 7,802 | 148,000 | 0.06% | ||
| 43 | AMERICAN INTERNATIONAL GROUP, INC. | 7,154 | 136,000 | 0.05% | ||
| 44 | BLACKROCK ADVISORS LLC | 6,557 | 125,000 | 0.05% | ||
| 45 | SG Americas Securities, LLC | 5,674 | 108,000 | 0.04% | ||
| 46 | INTEGRATED WEALTH MANAGEMENT | 4,500 | 86,000 | 0.03% | ||
| 47 | BANK OF AMERICA CORP /DE/ | 3,287 | 62,000 | 0.02% | ||
| 48 | MORGAN STANLEY | 3,122 | 59,000 | 0.02% | ||
| 49 | PANAGORA ASSET MANAGEMENT INC | 2,882 | 55,000 | 0.02% | ||
| 50 | WELLS FARGO & COMPANY/MN | 2,846 | 54,000 | 0.02% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
