| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Omega Fund Management, LLC | 2,600,410 | 33,831,000 | 14.98% | ||
| 2 | FMR LLC | 2,115,292 | 27,520,000 | 12.19% | ||
| 3 | BAUPOST GROUP LLC/MA | 2,044,498 | 26,599,000 | 11.78% | ||
| 4 | Abingworth LLP | 1,301,413 | 16,918,000 | 7.49% | ||
| 5 | Broadfin Capital, LLC | 786,134 | 10,228,000 | 4.53% | ||
| 6 | Tekla Capital Management LLC | 762,581 | 9,921,000 | 4.39% | ||
| 7 | VANGUARD GROUP INC | 575,617 | 7,489,000 | 3.32% | ||
| 8 | GENERAL AMERICAN INVESTORS CO INC | 540,252 | 7,029,000 | 3.11% | ||
| 9 | BlackRock Fund Advisors | 511,978 | 6,661,000 | 2.95% | ||
| 10 | Rock Springs Capital Management LP | 502,500 | 6,538,000 | 2.90% | ||
| 11 | Aisling Capital LLC | 482,680 | 6,280,000 | 2.78% | ||
| 12 | Fortress Investment Group LLC | 433,804 | 5,644,000 | 2.50% | ||
| 13 | Granahan Investment Management, LLC | 423,230 | 5,506,000 | 2.44% | ||
| 14 | BROWN BROTHERS HARRIMAN & CO | 367,902 | 4,786,000 | 2.12% | ||
| 15 | Roumell Asset Management, LLC | 284,811 | 3,705,000 | 1.64% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 233,401 | 3,037,000 | 1.35% | ||
| 17 | NORTHERN TRUST CORP | 226,581 | 2,947,000 | 1.31% | ||
| 18 | STATE STREET CORP | 195,975 | 2,549,000 | 1.13% | ||
| 19 | Numeric Investors LLC | 183,491 | 2,387,000 | 1.06% | ||
| 20 | SABBY MANAGEMENT, LLC | 175,000 | 2,277,000 | 1.01% | ||
| 21 | RENAISSANCE TECHNOLOGIES LLC | 143,513 | 1,867,000 | 0.83% | ||
| 22 | SPHERA FUNDS MANAGEMENT LTD. | 140,000 | 1,821,000 | 0.81% | ||
| 23 | DEUTSCHE BANK AG\ | 132,571 | 1,723,000 | 0.76% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 120,639 | 1,569,000 | 0.69% | ||
| 25 | SENZAR ASSET MANAGEMENT, LLC | 117,019 | 1,522,417 | 0.67% | ||
| 26 | BARCLAYS PLC | 105,000 | 1,366,000 | 0.60% | Call | |
| 27 | Lombard Odier Asset Management (USA) Corp | 101,966 | 1,327,000 | 0.59% | ||
| 28 | Point72 Asset Management, L.P. | 100,000 | 1,301,000 | 0.58% | ||
| 29 | DEERFIELD MANAGEMENT COMPANY, L.P. | 100,000 | 1,301,000 | 0.58% | ||
| 30 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 92,660 | 1,206,000 | 0.53% | ||
| 31 | Opus Point Partners Management, LLC | 80,000 | 1,041,000 | 0.46% | ||
| 32 | Granite Investment Partners, LLC | 78,201 | 1,017,000 | 0.45% | ||
| 33 | TURNER INVESTMENTS LLC | 76,760 | 999,000 | 0.44% | ||
| 34 | BlackRock Investment Management, LLC | 74,653 | 971,000 | 0.43% | ||
| 35 | NEA Management Company, LLC | 66,245 | 862,000 | 0.38% | ||
| 36 | Bank of New York Mellon Corp | 65,900 | 857,000 | 0.38% | ||
| 37 | Candriam S.C.A. | 60,000 | 781,000 | 0.35% | ||
| 38 | SECOR Capital Advisors, LP | 58,106 | 756,000 | 0.33% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 56,930 | 741,000 | 0.33% | ||
| 40 | GOLDMAN SACHS GROUP INC | 55,227 | 719,000 | 0.32% | ||
| 41 | GOLDMAN SACHS GROUP INC | 55,000 | 716,000 | 0.32% | Put | |
| 42 | BARCLAYS PLC | 50,000 | 651,000 | 0.29% | Put | |
| 43 | Omega Advisors Inc. | 45,700 | 595,000 | 0.26% | ||
| 44 | MILLENNIUM MANAGEMENT LLC | 41,617 | 541,000 | 0.24% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 38,722 | 504,000 | 0.22% | ||
| 46 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 38,503 | 501,000 | 0.22% | ||
| 47 | LPL Financial LLC | 29,450 | 403,000 | 0.18% | ||
| 48 | NEW YORK STATE COMMON RETIREMENT FUND | 30,148 | 392,000 | 0.17% | ||
| 49 | SHEPHERD KAPLAN KROCHUK, LLC | 29,334 | 382,000 | 0.17% | ||
| 50 | STONERIDGE INVESTMENT PARTNERS LLC | 27,736 | 361,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
