| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Omega Fund Management, LLC | 2,138,872 | 82,454,000 | 23.91% | ||
| 2 | FMR LLC | 1,735,218 | 66,893,000 | 19.39% | ||
| 3 | BAUPOST GROUP LLC/MA | 1,735,218 | 62,100,000 | 18.01% | ||
| 4 | Abingworth LLP | 1,301,413 | 49,974,000 | 14.49% | ||
| 5 | Aisling Capital LLC | 682,680 | 26,317,000 | 7.63% | ||
| 6 | Roumell Asset Management, LLC | 231,478 | 8,923,000 | 2.59% | ||
| 7 | VANGUARD GROUP INC | 218,754 | 8,433,000 | 2.45% | ||
| 8 | Broadfin Capital, LLC | 260,283 | 8,027,000 | 2.33% | ||
| 9 | NEA Management Company, LLC | 173,894 | 6,704,000 | 1.94% | ||
| 10 | D. E. Shaw & Co., Inc. | 98,315 | 3,790,000 | 1.10% | ||
| 11 | Bank of New York Mellon Corp | 90,326 | 3,482,000 | 1.01% | ||
| 12 | Opaleye Management Inc. | 80,000 | 3,084,000 | 0.89% | ||
| 13 | EcoR1 Capital, LLC | 78,958 | 3,044,000 | 0.88% | ||
| 14 | APPLETON PARTNERS INC/MA | 40,000 | 1,542,000 | 0.45% | ||
| 15 | DEUTSCHE BANK AG\ | 38,200 | 1,472,000 | 0.43% | ||
| 16 | DIMENSIONAL FUND ADVISORS LP | 37,545 | 1,447,000 | 0.42% | ||
| 17 | SG Americas Securities, LLC | 31,810 | 1,226,000 | 0.36% | ||
| 18 | ACUTA CAPITAL PARTNERS, LLC | 29,252 | 1,128,000 | 0.33% | ||
| 19 | MORGAN STANLEY | 24,324 | 938,000 | 0.27% | ||
| 20 | RENAISSANCE TECHNOLOGIES LLC | 23,364 | 901,000 | 0.26% | ||
| 21 | PANAGORA ASSET MANAGEMENT INC | 17,449 | 672,000 | 0.19% | ||
| 22 | CREDIT SUISSE AG/ | 14,731 | 568,000 | 0.16% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 9,859 | 380,000 | 0.11% | ||
| 24 | BlackRock Institutional Trust Company, N.A. | 7,887 | 304,000 | 0.09% | ||
| 25 | WELLS FARGO & COMPANY/MN | 6,845 | 264,000 | 0.08% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 5,320 | 205,000 | 0.06% | ||
| 27 | A.R.T. Advisors, LLC | 5,191 | 200,000 | 0.06% | ||
| 28 | BlackRock Fund Advisors | 4,001 | 154,000 | 0.04% | ||
| 29 | Waverly Advisors, LLC | 2,670 | 103,000 | 0.03% | ||
| 30 | UBS Group AG | 1,467 | 56,000 | 0.02% | ||
| 31 | BANK OF AMERICA CORP /DE/ | 1,330 | 51,000 | 0.01% | ||
| 32 | BLACKROCK ADVISORS LLC | 1,099 | 42,000 | 0.01% | ||
| 33 | Tower Research Capital LLC (TRC) | 227 | 9,000 | 0.00% | ||
| 34 | BlackRock Investment Management, LLC | 216 | 8,000 | 0.00% | ||
| 35 | Nationwide Fund Advisors | 103 | 4,000 | 0.00% | ||
| 36 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 14 | 1,000 | 0.00% | ||
| 37 | SIMPLEX TRADING, LLC | 8 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
