| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,754,306 | 75,236,000 | 22.43% | ||
| 2 | JPMORGAN CHASE & CO | 1,374,970 | 27,554,000 | 8.21% | ||
| 3 | RA CAPITAL MANAGEMENT, L.P. | 1,305,020 | 26,153,000 | 7.80% | ||
| 4 | VHCP Management, LLC | 870,269 | 17,441,000 | 5.20% | ||
| 5 | Tourbillon Capital Partners, L.P. | 784,176 | 15,715,000 | 4.68% | ||
| 6 | TIAA CREF INVESTMENT MANAGEMENT LLC | 757,879 | 15,188,000 | 4.53% | ||
| 7 | BlackRock Fund Advisors | 618,167 | 12,388,000 | 3.69% | ||
| 8 | VANGUARD GROUP INC | 596,607 | 11,956,000 | 3.56% | ||
| 9 | ALPS ADVISORS INC | 59,228 | 11,869,000 | 3.54% | ||
| 10 | Cormorant Asset Management, LP | 569,130 | 11,405,000 | 3.40% | ||
| 11 | FEDERATED HERMES, INC. | 410,200 | 8,220,000 | 2.45% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 375,110 | 7,517,000 | 2.24% | ||
| 13 | STATE STREET CORP | 356,767 | 7,147,000 | 2.13% | ||
| 14 | JENNISON ASSOCIATES LLC | 355,998 | 7,134,000 | 2.13% | ||
| 15 | PFM Health Sciences, LP | 295,579 | 5,923,000 | 1.77% | ||
| 16 | Rock Springs Capital Management LP | 285,000 | 5,711,000 | 1.70% | ||
| 17 | LORD, ABBETT & CO. LLC | 262,742 | 5,265,000 | 1.57% | ||
| 18 | NORTHERN TRUST CORP | 259,396 | 5,199,000 | 1.55% | ||
| 19 | RUSSELL FRANK CO/ | 231,862 | 4,646,000 | 1.38% | ||
| 20 | BELLEVUE ASSET MANAGEMENT AG | 230,000 | 4,609,000 | 1.37% | ||
| 21 | COLUMBUS CIRCLE INVESTORS | 208,086 | 4,170,000 | 1.24% | ||
| 22 | Numeric Investors LLC | 202,266 | 4,053,000 | 1.21% | ||
| 23 | BROWN ADVISORY INC | 194,981 | 3,907,000 | 1.16% | ||
| 24 | HIGHLAND CAPITAL MANAGEMENT LP | 162,400 | 3,254,000 | 0.97% | ||
| 25 | FIL Ltd | 160,152 | 3,209,000 | 0.96% | ||
| 26 | CI Global Investments Inc. | 150,000 | 3,006,000 | 0.90% | ||
| 27 | Hudson Bay Capital Management LP | 145,261 | 2,911,000 | 0.87% | ||
| 28 | SOROS FUND MANAGEMENT LLC | 127,600 | 2,557,000 | 0.76% | ||
| 29 | C WorldWide Group Holding A/S | 124,000 | 2,485,000 | 0.74% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 89,487 | 1,793,000 | 0.53% | ||
| 31 | RENAISSANCE TECHNOLOGIES LLC | 85,500 | 1,713,000 | 0.51% | ||
| 32 | Bank of New York Mellon Corp | 84,482 | 1,693,000 | 0.50% | ||
| 33 | BlackRock Investment Management, LLC | 82,179 | 1,647,000 | 0.49% | ||
| 34 | MILLENNIUM MANAGEMENT LLC | 50,000 | 1,002,000 | 0.30% | Put | |
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 49,263 | 988,000 | 0.29% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 42,969 | 861,000 | 0.26% | ||
| 37 | Trexquant Investment LP | 38,400 | 769,000 | 0.23% | ||
| 38 | Informed Momentum Co LLC | 35,656 | 715,000 | 0.21% | ||
| 39 | TEACHERS ADVISORS, LLC | 34,348 | 688,000 | 0.21% | ||
| 40 | ALLIANCEBERNSTEIN L.P. | 34,120 | 684,000 | 0.20% | ||
| 41 | PYRRHO CAPITAL MANAGEMENT, LP | 27,133 | 544,000 | 0.16% | ||
| 42 | FRANKLIN RESOURCES INC | 25,000 | 501,000 | 0.15% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 23,500 | 471,000 | 0.14% | Put | |
| 44 | DEUTSCHE BANK AG\ | 23,516 | 471,000 | 0.14% | ||
| 45 | NEW YORK STATE COMMON RETIREMENT FUND | 23,200 | 465,000 | 0.14% | ||
| 46 | RHUMBLINE ADVISERS | 20,749 | 416,000 | 0.12% | ||
| 47 | Swiss National Bank | 17,900 | 359,000 | 0.11% | ||
| 48 | METROPOLITAN LIFE INSURANCE CO/NY | 16,813 | 337,000 | 0.10% | ||
| 49 | SECTORAL ASSET MANAGEMENT INC | 16,498 | 331,000 | 0.10% | ||
| 50 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 15,943 | 320,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
