| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 1,555,355 | 47,563,000 | 21.46% | ||
| 2 | JPMORGAN CHASE & CO | 1,284,703 | 39,285,000 | 17.72% | ||
| 3 | VHCP Management, LLC | 870,269 | 26,018,000 | 11.74% | ||
| 4 | FMR LLC | 834,953 | 25,533,000 | 11.52% | ||
| 5 | MILLENNIUM MANAGEMENT LLC | 280,999 | 8,593,000 | 3.88% | ||
| 6 | BROWN ADVISORY INC | 221,513 | 6,774,000 | 3.06% | ||
| 7 | COLUMBUS CIRCLE INVESTORS | 220,825 | 6,753,000 | 3.05% | ||
| 8 | Cormorant Asset Management, LP | 219,130 | 6,701,000 | 3.02% | ||
| 9 | Rock Springs Capital Management LP | 199,051 | 6,087,000 | 2.75% | ||
| 10 | VANGUARD GROUP INC | 175,543 | 5,368,000 | 2.42% | ||
| 11 | HIGHLAND CAPITAL MANAGEMENT LP | 163,044 | 4,986,000 | 2.25% | ||
| 12 | Informed Momentum Co LLC | 162,485 | 4,969,000 | 2.24% | ||
| 13 | MONASHEE INVESTMENT MANAGEMENT LLC | 100,000 | 3,058,000 | 1.38% | ||
| 14 | NORTHERN TRUST CORP | 90,098 | 2,755,000 | 1.24% | ||
| 15 | PERCEPTIVE ADVISORS LLC | 85,288 | 2,608,000 | 1.18% | ||
| 16 | STATE STREET CORP | 80,807 | 2,469,000 | 1.11% | ||
| 17 | BELLEVUE ASSET MANAGEMENT AG | 80,000 | 2,446,000 | 1.10% | ||
| 18 | RUSSELL FRANK CO/ | 76,820 | 2,349,000 | 1.06% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 61,593 | 1,883,000 | 0.85% | ||
| 20 | Bank of New York Mellon Corp | 56,825 | 1,738,000 | 0.78% | ||
| 21 | TIAA CREF INVESTMENT MANAGEMENT LLC | 56,118 | 1,716,000 | 0.77% | ||
| 22 | PANAGORA ASSET MANAGEMENT INC | 53,681 | 1,642,000 | 0.74% | ||
| 23 | Tourbillon Capital Partners, L.P. | 50,000 | 1,529,000 | 0.69% | ||
| 24 | AMERIPRISE FINANCIAL INC | 40,225 | 1,230,000 | 0.55% | ||
| 25 | Candriam S.C.A. | 40,000 | 1,223,000 | 0.55% | ||
| 26 | MAZAMA CAPITAL MANAGEMENT INC | 33,867 | 1,036,000 | 0.47% | ||
| 27 | GOLDMAN SACHS GROUP INC | 23,221 | 710,000 | 0.32% | ||
| 28 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 19,276 | 590,000 | 0.27% | ||
| 29 | CITIGROUP INC | 18,866 | 577,000 | 0.26% | ||
| 30 | CITADEL ADVISORS LLC | 14,510 | 444,000 | 0.20% | ||
| 31 | SECTORAL ASSET MANAGEMENT INC | 12,656 | 387,000 | 0.17% | ||
| 32 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 12,400 | 379,000 | 0.17% | ||
| 33 | MOODY LYNN & LIEBERSON, LLC | 11,040 | 338,000 | 0.15% | ||
| 34 | GILDER GAGNON HOWE & CO LLC | 10,304 | 315,000 | 0.14% | ||
| 35 | Birchview Capital, LP | 7,500 | 229,000 | 0.10% | ||
| 36 | CIM INVESTMENT MANAGEMENT INC | 7,277 | 223,000 | 0.10% | ||
| 37 | ALLIANCEBERNSTEIN L.P. | 6,500 | 199,000 | 0.09% | ||
| 38 | TEACHERS ADVISORS, LLC | 6,490 | 198,000 | 0.09% | ||
| 39 | GLOBEFLEX CAPITAL L P | 6,121 | 187,000 | 0.08% | ||
| 40 | Nationwide Fund Advisors | 4,996 | 153,000 | 0.07% | ||
| 41 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 4,452 | 136,000 | 0.06% | ||
| 42 | AMERICAN INTERNATIONAL GROUP, INC. | 4,278 | 130,821 | 0.06% | ||
| 43 | UBS Group AG | 2,551 | 78,000 | 0.04% | ||
| 44 | MORGAN STANLEY | 967 | 30,000 | 0.01% | ||
| 45 | PRELUDE CAPITAL MANAGEMENT, LLC | 700 | 21,000 | 0.01% | ||
| 46 | B. Riley Wealth Management, Inc. | 434 | 13,000 | 0.01% | ||
| 47 | WELLS FARGO & COMPANY/MN | 339 | 10,000 | 0.00% | ||
| 48 | BARCLAYS PLC | 208 | 7,000 | 0.00% | ||
| 49 | BNP PARIBAS FINANCIAL MARKETS | 151 | 4,618 | 0.00% | ||
| 50 | BANK OF AMERICA CORP /DE/ | 18 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
