| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Kohlberg Kravis Roberts & Co. L.P. | 3,055,055 | 49,858,000 | 31.64% | ||
| 2 | RA CAPITAL MANAGEMENT, L.P. | 1,555,355 | 25,383,000 | 16.11% | ||
| 3 | FMR LLC | 1,186,853 | 17,311,000 | 10.99% | ||
| 4 | VHCP Management, LLC | 870,269 | 13,070,000 | 8.30% | ||
| 5 | WESTFIELD CAPITAL MANAGEMENT CO LP | 778,041 | 12,698,000 | 8.06% | ||
| 6 | JPMORGAN CHASE & CO | 735,319 | 12,001,000 | 7.62% | ||
| 7 | PERCEPTIVE ADVISORS LLC | 438,000 | 7,148,000 | 4.54% | ||
| 8 | Rock Springs Capital Management LP | 240,051 | 3,918,000 | 2.49% | ||
| 9 | BROWN ADVISORY INC | 223,900 | 3,654,000 | 2.32% | ||
| 10 | Cormorant Asset Management, LP | 222,200 | 3,626,000 | 2.30% | ||
| 11 | VANGUARD GROUP INC | 71,682 | 1,169,000 | 0.74% | ||
| 12 | NORTHERN TRUST CORP | 69,989 | 1,142,000 | 0.72% | ||
| 13 | MAZAMA CAPITAL MANAGEMENT INC | 63,635 | 1,039,000 | 0.66% | ||
| 14 | MORGAN STANLEY | 58,773 | 959,000 | 0.61% | ||
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 37,127 | 605,000 | 0.38% | ||
| 16 | Alyeska Investment Group, L.P. | 34,183 | 558,000 | 0.35% | ||
| 17 | STATE STREET CORP | 32,878 | 537,000 | 0.34% | ||
| 18 | PANAGORA ASSET MANAGEMENT INC | 29,115 | 475,000 | 0.30% | ||
| 19 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 22,768 | 372,000 | 0.24% | ||
| 20 | NORGES BANK | 20,000 | 326,000 | 0.21% | ||
| 21 | Bank of New York Mellon Corp | 16,752 | 273,000 | 0.17% | ||
| 22 | Cubist Systematic Strategies, LLC | 14,414 | 235,000 | 0.15% | ||
| 23 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 13,864 | 227,000 | 0.14% | ||
| 24 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 12,700 | 207,000 | 0.13% | ||
| 25 | Geduld E E | 10,000 | 163,000 | 0.10% | ||
| 26 | PNC FINANCIAL SERVICES GROUP, INC. | 7,580 | 124,000 | 0.08% | ||
| 27 | DEUTSCHE BANK AG\ | 6,335 | 103,000 | 0.07% | ||
| 28 | TEACHERS ADVISORS, LLC | 6,275 | 102,000 | 0.06% | ||
| 29 | Nationwide Fund Advisors | 4,767 | 78,000 | 0.05% | ||
| 30 | AMERICAN INTERNATIONAL GROUP, INC. | 4,278 | 69,817 | 0.04% | ||
| 31 | STRS OHIO | 2,400 | 39,000 | 0.02% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 1,523 | 25,000 | 0.02% | ||
| 33 | PRELUDE CAPITAL MANAGEMENT, LLC | 1,500 | 24,000 | 0.02% | ||
| 34 | CITIGROUP INC | 1,366 | 22,000 | 0.01% | ||
| 35 | UBS Group AG | 685 | 11,000 | 0.01% | ||
| 36 | BARCLAYS PLC | 388 | 6,000 | 0.00% | ||
| 37 | Tower Research Capital LLC (TRC) | 101 | 2,000 | 0.00% | ||
| 38 | ROYAL BANK OF CANADA | 33 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
