| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,708,029 | 78,262,000 | 18.04% | ||
| 2 | JPMORGAN CHASE & CO | 1,524,911 | 44,069,000 | 10.16% | ||
| 3 | RA CAPITAL MANAGEMENT, L.P. | 1,380,320 | 39,891,000 | 9.19% | ||
| 4 | VHCP Management, LLC | 870,269 | 25,151,000 | 5.80% | ||
| 5 | Tourbillon Capital Partners, L.P. | 765,000 | 22,109,000 | 5.10% | ||
| 6 | TIAA CREF INVESTMENT MANAGEMENT LLC | 759,214 | 21,941,000 | 5.06% | ||
| 7 | BlackRock Fund Advisors | 618,106 | 17,863,000 | 4.12% | ||
| 8 | Cormorant Asset Management, LP | 569,130 | 16,448,000 | 3.79% | ||
| 9 | Rock Springs Capital Management LP | 534,000 | 15,433,000 | 3.56% | ||
| 10 | VANGUARD GROUP INC | 529,657 | 15,307,000 | 3.53% | ||
| 11 | FEDERATED HERMES, INC. | 410,200 | 11,855,000 | 2.73% | ||
| 12 | LORD, ABBETT & CO. LLC | 369,945 | 10,692,000 | 2.46% | ||
| 13 | JENNISON ASSOCIATES LLC | 353,363 | 10,212,000 | 2.35% | ||
| 14 | RUSSELL FRANK CO/ | 343,404 | 9,925,000 | 2.29% | ||
| 15 | PFM Health Sciences, LP | 288,079 | 8,325,000 | 1.92% | ||
| 16 | STATE STREET CORP | 263,882 | 7,627,000 | 1.76% | ||
| 17 | COLUMBUS CIRCLE INVESTORS | 263,537 | 7,616,000 | 1.76% | ||
| 18 | PERCEPTIVE ADVISORS LLC | 258,716 | 7,477,000 | 1.72% | ||
| 19 | BELLEVUE ASSET MANAGEMENT AG | 250,000 | 7,225,000 | 1.67% | ||
| 20 | HIGHLAND CAPITAL MANAGEMENT LP | 202,800 | 5,861,000 | 1.35% | ||
| 21 | BROWN ADVISORY INC | 179,882 | 5,199,000 | 1.20% | ||
| 22 | BlackRock Institutional Trust Company, N.A. | 215,381 | 5,171,000 | 1.19% | ||
| 23 | MILLENNIUM MANAGEMENT LLC | 137,451 | 3,972,000 | 0.92% | ||
| 24 | SOROS FUND MANAGEMENT LLC | 127,600 | 3,688,000 | 0.85% | ||
| 25 | NORTHERN TRUST CORP | 107,715 | 3,114,000 | 0.72% | ||
| 26 | Bank of New York Mellon Corp | 94,909 | 2,743,000 | 0.63% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 86,616 | 2,503,000 | 0.58% | ||
| 28 | Cheyne Capital Management (UK) LLP | 84,778 | 2,451,000 | 0.56% | ||
| 29 | BlackRock Investment Management, LLC | 83,246 | 2,406,000 | 0.55% | ||
| 30 | C WorldWide Group Holding A/S | 60,000 | 1,734,000 | 0.40% | ||
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 46,987 | 1,358,000 | 0.31% | ||
| 32 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 43,069 | 1,245,000 | 0.29% | ||
| 33 | RENAISSANCE TECHNOLOGIES LLC | 40,907 | 1,182,000 | 0.27% | ||
| 34 | Candriam S.C.A. | 40,000 | 1,156,000 | 0.27% | ||
| 35 | ALPS ADVISORS INC | 37,511 | 1,084,000 | 0.25% | ||
| 36 | TEACHERS ADVISORS, LLC | 34,348 | 993,000 | 0.23% | ||
| 37 | ALLIANCEBERNSTEIN L.P. | 33,300 | 962,000 | 0.22% | ||
| 38 | SABBY MANAGEMENT, LLC | 30,000 | 867,000 | 0.20% | ||
| 39 | ROYAL BANK OF CANADA | 25,830 | 746,000 | 0.17% | ||
| 40 | FRED ALGER MANAGEMENT, LLC | 25,000 | 723,000 | 0.17% | ||
| 41 | DEUTSCHE BANK AG\ | 24,662 | 711,000 | 0.16% | ||
| 42 | RHUMBLINE ADVISERS | 19,885 | 575,000 | 0.13% | ||
| 43 | NEW YORK STATE COMMON RETIREMENT FUND | 17,435 | 504,000 | 0.12% | ||
| 44 | SECTORAL ASSET MANAGEMENT INC | 15,974 | 462,000 | 0.11% | ||
| 45 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 15,622 | 452,000 | 0.10% | ||
| 46 | BlackRock Japan Co. Ltd | 15,246 | 441,000 | 0.10% | ||
| 47 | Nationwide Fund Advisors | 15,232 | 440,000 | 0.10% | ||
| 48 | AMERICAN INTERNATIONAL GROUP, INC. | 13,819 | 399,369 | 0.09% | ||
| 49 | BLACKROCK ADVISORS LLC | 12,566 | 363,000 | 0.08% | ||
| 50 | VOYA INVESTMENT MANAGEMENT LLC | 11,331 | 327,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
