| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,865,513 | 124,524,000 | 32.17% | ||
| 2 | JPMORGAN CHASE & CO | 2,122,551 | 45,062,000 | 11.64% | ||
| 3 | RA CAPITAL MANAGEMENT, L.P. | 1,272,048 | 27,006,000 | 6.98% | ||
| 4 | BlackRock Fund Advisors | 1,120,135 | 23,780,000 | 6.14% | ||
| 5 | TIAA CREF INVESTMENT MANAGEMENT LLC | 719,453 | 15,274,000 | 3.95% | ||
| 6 | VANGUARD GROUP INC | 656,195 | 13,931,000 | 3.60% | ||
| 7 | VHCP Management, LLC | 611,010 | 12,972,000 | 3.35% | ||
| 8 | Cormorant Asset Management, LP | 569,130 | 12,083,000 | 3.12% | ||
| 9 | AXA S.A. | 448,789 | 9,528,000 | 2.46% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 390,255 | 8,285,000 | 2.14% | ||
| 11 | WELLINGTON MANAGEMENT GROUP LLP | 381,667 | 8,103,000 | 2.09% | ||
| 12 | STATE STREET CORP | 373,220 | 7,925,000 | 2.05% | ||
| 13 | BRIDGER MANAGEMENT, LLC | 341,121 | 7,242,000 | 1.87% | ||
| 14 | BELLEVUE GROUP AG | 287,000 | 6,093,000 | 1.57% | ||
| 15 | Rock Springs Capital Management LP | 282,000 | 5,987,000 | 1.55% | ||
| 16 | NORTHERN TRUST CORP | 269,180 | 5,715,000 | 1.48% | ||
| 17 | VHCP MANAGEMENT II, LLC | 259,259 | 5,504,000 | 1.42% | ||
| 18 | BROWN ADVISORY INC | 242,022 | 5,139,000 | 1.33% | ||
| 19 | COLUMBUS CIRCLE INVESTORS | 219,163 | 4,653,000 | 1.20% | ||
| 20 | LORD, ABBETT & CO. LLC | 169,209 | 3,592,000 | 0.93% | ||
| 21 | C WorldWide Group Holding A/S | 148,500 | 3,153,000 | 0.81% | ||
| 22 | EVENTIDE ASSET MANAGEMENT, LLC | 145,000 | 3,078,000 | 0.80% | ||
| 23 | TEACHERS ADVISORS, LLC | 134,302 | 2,851,000 | 0.74% | ||
| 24 | Point72 Asset Management, L.P. | 131,200 | 2,785,000 | 0.72% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 101,713 | 2,159,000 | 0.56% | ||
| 26 | Bank of New York Mellon Corp | 101,207 | 2,149,000 | 0.56% | ||
| 27 | Iguana Healthcare Management, LLC | 100,000 | 2,123,000 | 0.55% | ||
| 28 | BlackRock Investment Management, LLC | 83,903 | 1,781,000 | 0.46% | ||
| 29 | HANDELSBANKEN FONDER AB | 55,000 | 1,168,000 | 0.30% | ||
| 30 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 50,771 | 1,078,000 | 0.28% | ||
| 31 | EverPoint Asset Management, LLC | 50,000 | 1,062,000 | 0.27% | ||
| 32 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 49,938 | 1,060,000 | 0.27% | ||
| 33 | MORGAN STANLEY | 35,297 | 750,000 | 0.19% | ||
| 34 | ProShare Advisors LLC | 31,829 | 676,000 | 0.17% | ||
| 35 | ALLIANCEBERNSTEIN L.P. | 28,220 | 599,000 | 0.15% | ||
| 36 | CREDIT SUISSE AG/ | 27,900 | 592,000 | 0.15% | ||
| 37 | Swiss National Bank | 28,800 | 591,000 | 0.15% | ||
| 38 | FRANKLIN RESOURCES INC | 25,000 | 531,000 | 0.14% | ||
| 39 | NEW YORK STATE COMMON RETIREMENT FUND | 23,200 | 493,000 | 0.13% | ||
| 40 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 23,068 | 490,000 | 0.13% | ||
| 41 | RHUMBLINE ADVISERS | 22,559 | 479,000 | 0.12% | ||
| 42 | CITIGROUP INC | 17,082 | 363,000 | 0.09% | ||
| 43 | ROYAL BANK OF CANADA | 16,200 | 344,000 | 0.09% | ||
| 44 | Nationwide Fund Advisors | 14,732 | 328,000 | 0.08% | ||
| 45 | DekaBank Deutsche Girozentrale | 16,700 | 321,000 | 0.08% | ||
| 46 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16,297 | 314,000 | 0.08% | ||
| 47 | HANDELSINVEST INVESTERINGSFORVALTNING | 14,200 | 301,000 | 0.08% | ||
| 48 | AMERICAN INTERNATIONAL GROUP, INC. | 13,811 | 293,000 | 0.08% | ||
| 49 | WELLS FARGO & COMPANY/MN | 13,317 | 283,000 | 0.07% | ||
| 50 | TFS CAPITAL LLC | 13,167 | 280,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
