| 1 |
FMR LLC |
5,090,805 |
116,885,000 |
30.37% |
|
|
| 2 |
JPMORGAN CHASE & CO |
1,656,163 |
38,025,000 |
9.88% |
|
|
| 3 |
RA CAPITAL MANAGEMENT, L.P. |
1,272,048 |
29,206,000 |
7.59% |
|
|
| 4 |
BlackRock Fund Advisors |
1,087,011 |
24,958,000 |
6.48% |
|
|
| 5 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
739,099 |
16,970,000 |
4.41% |
|
|
| 6 |
VANGUARD GROUP INC |
615,619 |
14,135,000 |
3.67% |
|
|
| 7 |
VHCP Management, LLC |
611,010 |
14,029,000 |
3.65% |
|
|
| 8 |
Cormorant Asset Management, LP |
569,130 |
13,067,000 |
3.40% |
|
|
| 9 |
BlackRock Institutional Trust Company, N.A. |
388,230 |
8,914,000 |
2.32% |
|
|
| 10 |
JENNISON ASSOCIATES LLC |
367,021 |
8,427,000 |
2.19% |
|
|
| 11 |
STATE STREET CORP |
366,666 |
8,417,000 |
2.19% |
|
|
| 12 |
FEDERATED HERMES, INC. |
284,000 |
6,521,000 |
1.69% |
|
|
| 13 |
Rock Springs Capital Management LP |
282,000 |
6,475,000 |
1.68% |
|
|
| 14 |
COLUMBUS CIRCLE INVESTORS |
276,752 |
6,354,000 |
1.65% |
|
|
| 15 |
NORTHERN TRUST CORP |
266,732 |
6,124,000 |
1.59% |
|
|
| 16 |
VHCP MANAGEMENT II, LLC |
259,259 |
5,953,000 |
1.55% |
|
|
| 17 |
BELLEVUE ASSET MANAGEMENT AG |
257,000 |
5,901,000 |
1.53% |
|
|
| 18 |
HIGHLAND CAPITAL MANAGEMENT LP |
223,662 |
5,135,000 |
1.33% |
|
|
| 19 |
BROWN ADVISORY INC |
200,918 |
4,614,000 |
1.20% |
|
|
| 20 |
LORD, ABBETT & CO. LLC |
182,529 |
4,191,000 |
1.09% |
|
|
| 21 |
PFM Health Sciences, LP |
172,638 |
3,964,000 |
1.03% |
|
|
| 22 |
HANDELSBANKEN FONDER AB |
155,000 |
3,559,000 |
0.92% |
|
|
| 23 |
C WorldWide Group Holding A/S |
146,000 |
3,352,000 |
0.87% |
|
|
| 24 |
SOROS FUND MANAGEMENT LLC |
127,600 |
2,930,000 |
0.76% |
|
|
| 25 |
TEACHERS ADVISORS, LLC |
126,668 |
2,908,000 |
0.76% |
|
|
| 26 |
GEODE CAPITAL MANAGEMENT, LLC |
92,778 |
2,130,000 |
0.55% |
|
|
| 27 |
Bank of New York Mellon Corp |
82,935 |
1,904,000 |
0.49% |
|
|
| 28 |
BlackRock Investment Management, LLC |
82,201 |
1,887,000 |
0.49% |
|
|
| 29 |
Numeric Investors LLC |
81,118 |
1,862,000 |
0.48% |
|
|
| 30 |
Iguana Healthcare Management, LLC |
75,000 |
1,722,000 |
0.45% |
|
|
| 31 |
RUSSELL FRANK CO/ |
55,281 |
1,289,000 |
0.33% |
|
|
| 32 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
50,108 |
1,151,000 |
0.30% |
|
|
| 33 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
43,658 |
1,002,000 |
0.26% |
|
|
| 34 |
ProShare Advisors LLC |
34,708 |
797,000 |
0.21% |
|
|
| 35 |
CREDIT SUISSE AG/ |
33,929 |
780,000 |
0.20% |
|
|
| 36 |
STIFEL FINANCIAL CORP |
342 |
754,000 |
0.20% |
|
|
| 37 |
AEGON ASSET MANAGEMENT UK PLC |
31,338 |
719,207 |
0.19% |
|
|
| 38 |
ALLIANCEBERNSTEIN L.P. |
34,120 |
684,000 |
0.18% |
|
|
| 39 |
FRANKLIN RESOURCES INC |
25,000 |
574,000 |
0.15% |
|
|
| 40 |
Swiss National Bank |
23,500 |
540,000 |
0.14% |
|
|
| 41 |
NEW YORK STATE COMMON RETIREMENT FUND |
23,200 |
533,000 |
0.14% |
|
|
| 42 |
RHUMBLINE ADVISERS |
22,454 |
516,000 |
0.13% |
|
|
| 43 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
16,117 |
370,000 |
0.10% |
|
|
| 44 |
SECTORAL ASSET MANAGEMENT INC |
15,940 |
366,000 |
0.10% |
|
|
| 45 |
Nationwide Fund Advisors |
15,447 |
355,000 |
0.09% |
|
|
| 46 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
14,300 |
328,000 |
0.09% |
|
|
| 47 |
HANDELSINVEST INVESTERINGSFORVALTNING |
14,200 |
326,000 |
0.08% |
|
|
| 48 |
AMERICAN INTERNATIONAL GROUP, INC. |
13,811 |
317,000 |
0.08% |
|
|
| 49 |
HIGHBRIDGE CAPITAL MANAGEMENT LLC |
11,700 |
269,000 |
0.07% |
Put |
|
| 50 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
11,499 |
264,000 |
0.07% |
|
|
