| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,547,818 | 184,321,000 | 21.87% | ||
| 2 | Kohlberg Kravis Roberts & Co. L.P. | 3,055,055 | 86,000,000 | 10.20% | ||
| 3 | JPMORGAN CHASE & CO | 1,564,868 | 44,051,000 | 5.23% | ||
| 4 | BlackRock Fund Advisors | 1,559,843 | 43,910,000 | 5.21% | ||
| 5 | WELLINGTON MANAGEMENT GROUP LLP | 1,236,329 | 34,802,000 | 4.13% | ||
| 6 | VANGUARD GROUP INC | 1,169,842 | 32,932,000 | 3.91% | ||
| 7 | STATE STREET CORP | 950,475 | 26,754,000 | 3.17% | ||
| 8 | ORBIMED ADVISORS LLC | 850,100 | 23,930,000 | 2.84% | ||
| 9 | PRICE T ROWE ASSOCIATES INC /MD/ | 844,832 | 23,782,000 | 2.82% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 740,118 | 20,834,000 | 2.47% | ||
| 11 | Point72 Asset Management, L.P. | 601,034 | 16,919,000 | 2.01% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 526,600 | 14,824,000 | 1.76% | ||
| 13 | Cormorant Asset Management, LP | 519,090 | 14,612,000 | 1.73% | ||
| 14 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 501,673 | 14,121,000 | 1.68% | ||
| 15 | Rock Springs Capital Management LP | 484,500 | 13,639,000 | 1.62% | ||
| 16 | PICTET ASSET MANAGEMENT LTD | 440,356 | 12,396,000 | 1.47% | ||
| 17 | Carlson Capital, L.P. | 400,662 | 11,279,000 | 1.34% | ||
| 18 | HIGHLAND CAPITAL MANAGEMENT LP | 357,255 | 10,057,000 | 1.19% | ||
| 19 | NORTHERN TRUST CORP | 357,191 | 10,055,000 | 1.19% | ||
| 20 | BROWN ADVISORY INC | 336,000 | 9,460,000 | 1.12% | ||
| 21 | BRIDGER MANAGEMENT, LLC | 329,345 | 9,271,000 | 1.10% | ||
| 22 | AXA S.A. | 309,733 | 8,719,000 | 1.03% | ||
| 23 | VHCP Management, LLC | 305,505 | 8,600,000 | 1.02% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 278,543 | 7,841,000 | 0.93% | ||
| 25 | Candriam S.C.A. | 266,000 | 7,488,000 | 0.89% | ||
| 26 | LORD, ABBETT & CO. LLC | 262,554 | 7,391,000 | 0.88% | ||
| 27 | AMERIPRISE FINANCIAL INC | 256,371 | 7,218,000 | 0.86% | ||
| 28 | JHL Capital Group LLC | 250,000 | 7,038,000 | 0.84% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 238,610 | 6,716,000 | 0.80% | ||
| 30 | COLUMBUS CIRCLE INVESTORS | 211,181 | 5,945,000 | 0.71% | ||
| 31 | CITADEL ADVISORS LLC | 209,612 | 5,900,000 | 0.70% | ||
| 32 | BELLEVUE GROUP AG | 175,000 | 4,926,000 | 0.58% | ||
| 33 | Allianz Asset Management GmbH | 162,605 | 4,577,000 | 0.54% | ||
| 34 | TEACHERS ADVISORS, LLC | 147,753 | 4,159,000 | 0.49% | ||
| 35 | MORGAN STANLEY | 146,149 | 4,114,000 | 0.49% | ||
| 36 | EVENTIDE ASSET MANAGEMENT, LLC | 145,000 | 4,082,000 | 0.48% | ||
| 37 | CREDIT SUISSE AG/ | 142,155 | 4,002,000 | 0.47% | ||
| 38 | Bank of New York Mellon Corp | 140,032 | 3,942,000 | 0.47% | ||
| 39 | D. E. Shaw & Co., Inc. | 136,458 | 3,841,000 | 0.46% | ||
| 40 | VHCP MANAGEMENT II, LLC | 129,629 | 3,649,000 | 0.43% | ||
| 41 | KENNEDY CAPITAL MANAGEMENT LLC | 122,798 | 3,457,000 | 0.41% | ||
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 119,464 | 3,363,000 | 0.40% | ||
| 43 | TWO SIGMA INVESTMENTS, LP | 115,480 | 3,251,000 | 0.39% | ||
| 44 | BlackRock Investment Management, LLC | 115,414 | 3,249,000 | 0.39% | ||
| 45 | Rhenman & Partners Asset Management AB | 111,357 | 3,135,000 | 0.37% | ||
| 46 | DEUTSCHE BANK AG\ | 100,679 | 2,831,000 | 0.34% | ||
| 47 | EverPoint Asset Management, LLC | 100,000 | 2,815,000 | 0.33% | ||
| 48 | C WorldWide Group Holding A/S | 94,676 | 2,665,000 | 0.32% | ||
| 49 | Tekla Capital Management LLC | 90,000 | 2,534,000 | 0.30% | ||
| 50 | Lombard Odier Asset Management (Switzerland) SA | 75,000 | 2,111,000 | 0.25% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
