| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,507,031 | 174,259,000 | 23.00% | ||
| 2 | Kohlberg Kravis Roberts & Co. L.P. | 3,055,055 | 81,814,000 | 10.80% | ||
| 3 | JPMORGAN CHASE & CO | 1,930,979 | 51,712,000 | 6.82% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 1,550,233 | 41,515,000 | 5.48% | ||
| 5 | BlackRock Fund Advisors | 1,389,802 | 37,219,000 | 4.91% | ||
| 6 | VANGUARD GROUP INC | 1,029,701 | 27,575,000 | 3.64% | ||
| 7 | MILLENNIUM MANAGEMENT LLC | 1,006,817 | 26,963,000 | 3.56% | ||
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 831,322 | 22,263,000 | 2.94% | ||
| 9 | STATE STREET CORP | 801,707 | 21,466,000 | 2.83% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 715,475 | 19,160,000 | 2.53% | ||
| 11 | ORBIMED ADVISORS LLC | 671,600 | 17,985,000 | 2.37% | ||
| 12 | Cormorant Asset Management, LP | 576,106 | 15,428,000 | 2.04% | ||
| 13 | Rock Springs Capital Management LP | 467,500 | 12,520,000 | 1.65% | ||
| 14 | TIAA CREF INVESTMENT MANAGEMENT LLC | 463,914 | 12,424,000 | 1.64% | ||
| 15 | PICTET ASSET MANAGEMENT LTD | 380,092 | 10,179,000 | 1.34% | ||
| 16 | NORTHERN TRUST CORP | 378,017 | 10,123,000 | 1.34% | ||
| 17 | HIGHLAND CAPITAL MANAGEMENT LP | 372,505 | 9,976,000 | 1.32% | ||
| 18 | LORD, ABBETT & CO. LLC | 363,734 | 9,740,000 | 1.29% | ||
| 19 | BRIDGER MANAGEMENT, LLC | 359,886 | 9,638,000 | 1.27% | ||
| 20 | BROWN ADVISORY INC | 322,902 | 8,648,000 | 1.14% | ||
| 21 | COLUMBUS CIRCLE INVESTORS | 316,177 | 8,467,000 | 1.12% | ||
| 22 | VHCP Management, LLC | 305,505 | 8,181,000 | 1.08% | ||
| 23 | AXA S.A. | 303,822 | 8,136,000 | 1.07% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 216,161 | 5,787,000 | 0.76% | ||
| 25 | DEUTSCHE BANK AG\ | 206,989 | 5,540,000 | 0.73% | ||
| 26 | BELLEVUE GROUP AG | 202,000 | 5,410,000 | 0.71% | ||
| 27 | Candriam S.C.A. | 191,000 | 5,115,000 | 0.68% | ||
| 28 | CREDIT SUISSE AG/ | 172,239 | 4,612,000 | 0.61% | ||
| 29 | C WorldWide Group Holding A/S | 156,800 | 4,199,000 | 0.55% | ||
| 30 | TEACHERS ADVISORS, LLC | 145,379 | 3,893,000 | 0.51% | ||
| 31 | EVENTIDE ASSET MANAGEMENT, LLC | 145,000 | 3,883,000 | 0.51% | ||
| 32 | Allianz Asset Management GmbH | 142,305 | 3,741,000 | 0.49% | ||
| 33 | Bank of New York Mellon Corp | 134,127 | 3,592,000 | 0.47% | ||
| 34 | Rhenman & Partners Asset Management AB | 131,357 | 3,517,740 | 0.46% | ||
| 35 | VHCP MANAGEMENT II, LLC | 129,629 | 3,471,000 | 0.46% | ||
| 36 | CITADEL ADVISORS LLC | 119,231 | 3,192,000 | 0.42% | ||
| 37 | BlackRock Investment Management, LLC | 116,060 | 3,108,000 | 0.41% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 113,833 | 3,049,000 | 0.40% | ||
| 39 | D. E. Shaw & Co., Inc. | 101,673 | 2,723,000 | 0.36% | ||
| 40 | Lombard Odier Asset Management (Switzerland) SA | 100,000 | 2,678,000 | 0.35% | ||
| 41 | MILLENNIUM MANAGEMENT LLC | 100,000 | 2,678,000 | 0.35% | Put | |
| 42 | Spark Investment Management LLC | 84,900 | 2,273,000 | 0.30% | ||
| 43 | BLACKROCK ADVISORS LLC | 77,869 | 2,085,000 | 0.28% | ||
| 44 | Sio Capital Management, LLC | 73,053 | 1,956,000 | 0.26% | ||
| 45 | HBK INVESTMENTS L P | 63,500 | 1,701,000 | 0.22% | ||
| 46 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 62,440 | 1,672,000 | 0.22% | ||
| 47 | MACQUARIE GROUP LTD | 58,255 | 1,560,000 | 0.21% | ||
| 48 | MORGAN STANLEY | 56,873 | 1,523,000 | 0.20% | ||
| 49 | KENNEDY CAPITAL MANAGEMENT LLC | 54,829 | 1,468,000 | 0.19% | ||
| 50 | Numeric Investors LLC | 54,700 | 1,465,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
