| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 750,000 | 11,513,000 | 33.77% | ||
| 2 | Avoro Capital Advisors LLC | 371,111 | 5,697,000 | 16.71% | ||
| 3 | ACUTA CAPITAL PARTNERS, LLC | 300,000 | 4,605,000 | 13.51% | ||
| 4 | BAKER BROS. ADVISORS LP | 250,000 | 3,838,000 | 11.26% | ||
| 5 | PERCEPTIVE ADVISORS LLC | 200,000 | 3,070,000 | 9.01% | ||
| 6 | MENORA MIVTACHIM HOLDINGS LTD. | 106,700 | 1,638,000 | 4.81% | ||
| 7 | Foresite Capital Management II, LLC | 74,385 | 1,142,000 | 3.35% | ||
| 8 | PURA VIDA INVESTMENTS, LLC | 53,000 | 1,006,000 | 2.95% | ||
| 9 | Opaleye Management Inc. | 26,000 | 399,000 | 1.17% | ||
| 10 | OPPENHEIMER & CO INC | 18,708 | 287,000 | 0.84% | ||
| 11 | GOLDMAN SACHS GROUP INC | 18,051 | 277,000 | 0.81% | ||
| 12 | ALPS ADVISORS INC | 16,873 | 259,000 | 0.76% | ||
| 13 | HighTower Advisors, LLC | 10,000 | 154,000 | 0.45% | ||
| 14 | MORGAN STANLEY | 8,095 | 125,000 | 0.37% | ||
| 15 | ROYAL BANK OF CANADA | 1,368 | 21,000 | 0.06% | ||
| 16 | UBS Group AG | 1,303 | 20,000 | 0.06% | ||
| 17 | US BANCORP \DE\ | 1,000 | 15,000 | 0.04% | ||
| 18 | Edge Wealth Management LLC | 500 | 8,000 | 0.02% | ||
| 19 | BANK OF AMERICA CORP /DE/ | 500 | 8,000 | 0.02% | ||
| 20 | DEUTSCHE BANK AG\ | 300 | 4,000 | 0.01% | ||
| 21 | CITIGROUP INC | 151 | 2,000 | 0.01% | ||
| 22 | Tower Research Capital LLC (TRC) | 0 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
