| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | SCOPIA CAPITAL MANAGEMENT LP | 3,383,358 | 62,558,000 | 36.59% | ||
| 2 | Redmile Group, LLC | 805,246 | 14,889,000 | 8.71% | ||
| 3 | Avoro Capital Advisors LLC | 686,303 | 12,690,000 | 7.42% | ||
| 4 | MENORA MIVTACHIM HOLDINGS LTD. | 590,724 | 10,922,000 | 6.39% | ||
| 5 | ACUTA CAPITAL PARTNERS, LLC | 462,956 | 8,560,000 | 5.01% | ||
| 6 | BlackRock Fund Advisors | 353,080 | 6,528,000 | 3.82% | ||
| 7 | BAKER BROS. ADVISORS LP | 305,000 | 5,639,000 | 3.30% | ||
| 8 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 277,000 | 5,122,000 | 3.00% | ||
| 9 | PERCEPTIVE ADVISORS LLC | 264,114 | 4,883,000 | 2.86% | ||
| 10 | ArrowMark Colorado Holdings LLC | 260,682 | 4,820,000 | 2.82% | ||
| 11 | SPHERA FUNDS MANAGEMENT LTD. | 253,513 | 4,687,000 | 2.74% | ||
| 12 | SENZAR ASSET MANAGEMENT, LLC | 171,300 | 3,167,337 | 1.85% | ||
| 13 | SECTORAL ASSET MANAGEMENT INC | 161,971 | 2,995,000 | 1.75% | ||
| 14 | Rhenman & Partners Asset Management AB | 144,546 | 2,672,656 | 1.56% | ||
| 15 | NEXTHERA CAPITAL LP | 131,000 | 2,422,000 | 1.42% | ||
| 16 | Ghost Tree Capital, LLC | 131,000 | 2,422,000 | 1.42% | ||
| 17 | MENTA CAPITAL LLC | 111,696 | 2,065,000 | 1.21% | ||
| 18 | Opaleye Management Inc. | 98,500 | 1,821,000 | 1.07% | ||
| 19 | BAILARD, INC. | 86,500 | 1,599,000 | 0.94% | ||
| 20 | FOLGER HILL ASSET MANAGEMENT LP | 65,913 | 1,219,000 | 0.71% | ||
| 21 | Nicholas Investment Partners, LP | 58,999 | 1,091,000 | 0.64% | ||
| 22 | BlackRock Institutional Trust Company, N.A. | 50,813 | 940,000 | 0.55% | ||
| 23 | PURA VIDA INVESTMENTS, LLC | 40,183 | 743,000 | 0.43% | ||
| 24 | D. E. Shaw & Co., Inc. | 39,657 | 733,000 | 0.43% | ||
| 25 | STATE STREET CORP | 31,609 | 584,000 | 0.34% | ||
| 26 | NORTHERN TRUST CORP | 29,570 | 547,000 | 0.32% | ||
| 27 | ALPS ADVISORS INC | 27,598 | 510,000 | 0.30% | ||
| 28 | VICTORY CAPITAL MANAGEMENT INC | 25,360 | 469,000 | 0.27% | ||
| 29 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 23,089 | 427,000 | 0.25% | ||
| 30 | Swiss National Bank | 22,800 | 422,000 | 0.25% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 18,700 | 346,000 | 0.20% | Put | |
| 32 | MORGAN STANLEY | 15,104 | 279,000 | 0.16% | ||
| 33 | ACADIAN ASSET MANAGEMENT LLC | 14,656 | 271,000 | 0.16% | ||
| 34 | DAFNA Capital Management LLC | 14,421 | 267,000 | 0.16% | ||
| 35 | Bank of New York Mellon Corp | 14,003 | 259,000 | 0.15% | ||
| 36 | ProShare Advisors LLC | 13,655 | 252,000 | 0.15% | ||
| 37 | GOLDMAN SACHS GROUP INC | 12,387 | 229,000 | 0.13% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 8,717 | 161,000 | 0.09% | ||
| 39 | BANK OF AMERICA CORP /DE/ | 7,938 | 146,000 | 0.09% | ||
| 40 | DEUTSCHE BANK AG\ | 7,364 | 136,000 | 0.08% | ||
| 41 | VAN ECK ASSOCIATES CORP | 6,373 | 118,000 | 0.07% | ||
| 42 | GROUP ONE TRADING LLC | 4,522 | 84,000 | 0.05% | ||
| 43 | NEW YORK STATE COMMON RETIREMENT FUND | 3,600 | 67,000 | 0.04% | ||
| 44 | CITIGROUP INC | 3,492 | 65,000 | 0.04% | ||
| 45 | BARCLAYS PLC | 3,392 | 62,000 | 0.04% | ||
| 46 | PENSERRA CAPITAL MANAGEMENT LLC | 1,788 | 33,000 | 0.02% | ||
| 47 | UBS Group AG | 1,505 | 28,000 | 0.02% | ||
| 48 | ROYAL BANK OF CANADA | 700 | 13,000 | 0.01% | ||
| 49 | INTEGRATED WEALTH MANAGEMENT | 500 | 9,000 | 0.01% | ||
| 50 | Focused Wealth Management, Inc | 75 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
