| 1 |
SCOPIA CAPITAL MANAGEMENT LP |
3,383,358 |
54,980,000 |
38.26% |
|
|
| 2 |
Redmile Group, LLC |
821,445 |
13,348,000 |
9.29% |
|
|
| 3 |
ACUTA CAPITAL PARTNERS, LLC |
634,000 |
10,303,000 |
7.17% |
|
|
| 4 |
MENORA MIVTACHIM HOLDINGS LTD. |
590,724 |
9,599,000 |
6.68% |
|
|
| 5 |
Avoro Capital Advisors LLC |
557,003 |
9,051,000 |
6.30% |
|
|
| 6 |
BlackRock Fund Advisors |
339,395 |
5,515,000 |
3.84% |
|
|
| 7 |
BAKER BROS. ADVISORS LP |
305,000 |
4,956,000 |
3.45% |
|
|
| 8 |
PERCEPTIVE ADVISORS LLC |
270,000 |
4,388,000 |
3.05% |
|
|
| 9 |
SPHERA FUNDS MANAGEMENT LTD. |
258,513 |
4,201,000 |
2.92% |
|
|
| 10 |
FORESITE CAPITAL MANAGEMENT III, LLC |
201,469 |
3,274,000 |
2.28% |
|
|
| 11 |
SENZAR ASSET MANAGEMENT, LLC |
195,800 |
3,181,750 |
2.21% |
|
|
| 12 |
ArrowMark Colorado Holdings LLC |
178,603 |
2,902,000 |
2.02% |
|
|
| 13 |
Rhenman & Partners Asset Management AB |
144,546 |
2,349,000 |
1.63% |
|
|
| 14 |
MENTA CAPITAL LLC |
110,784 |
1,800,000 |
1.25% |
|
|
| 15 |
SECTORAL ASSET MANAGEMENT INC |
104,971 |
1,706,000 |
1.19% |
|
|
| 16 |
BAILARD, INC. |
86,500 |
1,406,000 |
0.98% |
|
|
| 17 |
Foresite Capital Management II, LLC |
83,211 |
1,352,000 |
0.94% |
|
|
| 18 |
FOLGER HILL ASSET MANAGEMENT LP |
65,913 |
1,071,000 |
0.75% |
|
|
| 19 |
Opaleye Management Inc. |
52,500 |
853,000 |
0.59% |
|
|
| 20 |
BlackRock Institutional Trust Company, N.A. |
51,394 |
835,000 |
0.58% |
|
|
| 21 |
D. E. Shaw & Co., Inc. |
46,476 |
755,000 |
0.53% |
|
|
| 22 |
Nicholas Investment Partners, LP |
40,368 |
656,000 |
0.46% |
|
|
| 23 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
31,100 |
505,000 |
0.35% |
Put |
|
| 24 |
ALPS ADVISORS INC |
30,412 |
494,000 |
0.34% |
|
|
| 25 |
NORTHERN TRUST CORP |
27,335 |
444,000 |
0.31% |
|
|
| 26 |
PURA VIDA INVESTMENTS, LLC |
24,683 |
401,000 |
0.28% |
|
|
| 27 |
ACADIAN ASSET MANAGEMENT LLC |
23,255 |
378,000 |
0.26% |
|
|
| 28 |
PARAMETRIC PORTFOLIO ASSOCIATES LLC |
23,089 |
375,000 |
0.26% |
|
|
| 29 |
Swiss National Bank |
22,800 |
371,000 |
0.26% |
|
|
| 30 |
STATE STREET CORP |
19,709 |
320,000 |
0.22% |
|
|
| 31 |
MORGAN STANLEY |
17,682 |
287,000 |
0.20% |
|
|
| 32 |
ProShare Advisors LLC |
16,119 |
262,000 |
0.18% |
|
|
| 33 |
Bank of New York Mellon Corp |
15,115 |
246,000 |
0.17% |
|
|
| 34 |
DAFNA Capital Management LLC |
14,421 |
234,000 |
0.16% |
|
|
| 35 |
DEUTSCHE BANK AG\ |
12,065 |
195,000 |
0.14% |
|
|
| 36 |
BANK OF AMERICA CORP /DE/ |
9,514 |
155,000 |
0.11% |
|
|
| 37 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
8,717 |
142,000 |
0.10% |
|
|
| 38 |
VAN ECK ASSOCIATES CORP |
6,350 |
103,000 |
0.07% |
|
|
| 39 |
GROUP ONE TRADING LLC |
4,722 |
77,000 |
0.05% |
|
|
| 40 |
NEW YORK STATE COMMON RETIREMENT FUND |
3,600 |
59,000 |
0.04% |
|
|
| 41 |
SIMPLEX TRADING, LLC |
3,350 |
54,000 |
0.04% |
|
|
| 42 |
CITIGROUP INC |
2,582 |
42,000 |
0.03% |
|
|
| 43 |
UBS Group AG |
1,406 |
23,000 |
0.02% |
|
|
| 44 |
PENSERRA CAPITAL MANAGEMENT LLC |
1,341 |
22,000 |
0.02% |
|
|
| 45 |
Walleye Trading LLC |
1,200 |
20,000 |
0.01% |
|
|
| 46 |
ROYAL BANK OF CANADA |
700 |
11,000 |
0.01% |
|
|
| 47 |
INTEGRATED WEALTH MANAGEMENT |
500 |
8,000 |
0.01% |
|
|
| 48 |
BARCLAYS PLC |
280 |
5,000 |
0.00% |
|
|
| 49 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
237 |
4,000 |
0.00% |
|
|
| 50 |
Focused Wealth Management, Inc |
75 |
1,000 |
0.00% |
|
|
