| 1 |
SCOPIA CAPITAL MANAGEMENT LP |
3,383,359 |
47,773,000 |
38.01% |
|
|
| 2 |
Redmile Group, LLC |
1,180,887 |
16,674,000 |
13.27% |
|
|
| 3 |
ACUTA CAPITAL PARTNERS, LLC |
826,799 |
11,674,000 |
9.29% |
|
|
| 4 |
Avoro Capital Advisors LLC |
537,477 |
7,589,000 |
6.04% |
|
|
| 5 |
BlackRock Fund Advisors |
342,315 |
4,833,000 |
3.85% |
|
|
| 6 |
BAKER BROS. ADVISORS LP |
305,000 |
4,307,000 |
3.43% |
|
|
| 7 |
FORESITE CAPITAL MANAGEMENT III, LLC |
292,371 |
4,128,000 |
3.28% |
|
|
| 8 |
PERCEPTIVE ADVISORS LLC |
270,000 |
3,812,000 |
3.03% |
|
|
| 9 |
SENZAR ASSET MANAGEMENT, LLC |
215,400 |
3,041,448 |
2.42% |
|
|
| 10 |
MENORA MIVTACHIM HOLDINGS LTD. |
190,724 |
2,693,000 |
2.14% |
|
|
| 11 |
SPHERA FUNDS MANAGEMENT LTD. |
166,359 |
2,349,000 |
1.87% |
|
|
| 12 |
ArrowMark Colorado Holdings LLC |
159,170 |
2,247,000 |
1.79% |
|
|
| 13 |
RA CAPITAL MANAGEMENT, L.P. |
144,671 |
2,043,000 |
1.63% |
|
|
| 14 |
Foresite Capital Management II, LLC |
119,781 |
1,691,000 |
1.35% |
|
|
| 15 |
GOLDMAN SACHS GROUP INC |
104,334 |
1,473,000 |
1.17% |
|
|
| 16 |
MENTA CAPITAL LLC |
95,924 |
1,354,000 |
1.08% |
|
|
| 17 |
BAILARD, INC. |
86,500 |
1,221,000 |
0.97% |
|
|
| 18 |
NEXTHERA CAPITAL LP |
70,000 |
988,000 |
0.79% |
|
|
| 19 |
FOLGER HILL ASSET MANAGEMENT LP |
65,913 |
931,000 |
0.74% |
|
|
| 20 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
55,700 |
786,000 |
0.63% |
Put |
|
| 21 |
Opaleye Management Inc. |
38,500 |
544,000 |
0.43% |
|
|
| 22 |
BlackRock Institutional Trust Company, N.A. |
29,699 |
419,000 |
0.33% |
|
|
| 23 |
ACADIAN ASSET MANAGEMENT LLC |
28,643 |
405,000 |
0.32% |
|
|
| 24 |
ALPS ADVISORS INC |
24,220 |
342,000 |
0.27% |
|
|
| 25 |
PARAMETRIC PORTFOLIO ASSOCIATES LLC |
23,089 |
326,000 |
0.26% |
|
|
| 26 |
D. E. Shaw & Co., Inc. |
18,658 |
263,000 |
0.21% |
|
|
| 27 |
MORGAN STANLEY |
18,081 |
256,000 |
0.20% |
|
|
| 28 |
ProShare Advisors LLC |
15,946 |
225,000 |
0.18% |
|
|
| 29 |
Swiss National Bank |
15,200 |
210,000 |
0.17% |
|
|
| 30 |
HighTower Advisors, LLC |
12,150 |
171,000 |
0.14% |
|
|
| 31 |
DekaBank Deutsche Girozentrale |
9,200 |
132,000 |
0.11% |
|
|
| 32 |
GROUP ONE TRADING LLC |
8,122 |
115,000 |
0.09% |
|
|
| 33 |
DEUTSCHE BANK AG\ |
7,850 |
110,000 |
0.09% |
|
|
| 34 |
VAN ECK ASSOCIATES CORP |
6,918 |
98,000 |
0.08% |
|
|
| 35 |
BANK OF AMERICA CORP /DE/ |
6,722 |
95,000 |
0.08% |
|
|
| 36 |
WELLS FARGO & COMPANY/MN |
5,500 |
78,000 |
0.06% |
|
|
| 37 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
4,676 |
66,000 |
0.05% |
|
|
| 38 |
CITIGROUP INC |
4,176 |
59,000 |
0.05% |
|
|
| 39 |
EDMOND DE ROTHSCHILD (EUROPE) |
1,600 |
23,000 |
0.02% |
|
|
| 40 |
EDMOND DE ROTHSCHILD HOLDING S.A. |
1,600 |
23,000 |
0.02% |
|
|
| 41 |
SIMPLEX TRADING, LLC |
1,609 |
22,000 |
0.02% |
|
|
| 42 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
1,537 |
22,000 |
0.02% |
|
|
| 43 |
DAFNA Capital Management LLC |
1,202 |
17,000 |
0.01% |
|
|
| 44 |
PENSERRA CAPITAL MANAGEMENT LLC |
1,230 |
17,000 |
0.01% |
|
|
| 45 |
TURNER INVESTMENTS LLC |
1,000 |
14,000 |
0.01% |
|
|
| 46 |
ROYAL BANK OF CANADA |
700 |
10,000 |
0.01% |
|
|
| 47 |
UBS Group AG |
543 |
8,000 |
0.01% |
|
|
| 48 |
Tower Research Capital LLC (TRC) |
341 |
5,000 |
0.00% |
|
|
| 49 |
Focused Wealth Management, Inc |
75 |
1,000 |
0.00% |
|
|
| 50 |
BARCLAYS PLC |
86 |
1,000 |
0.00% |
|
|
