| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Redmile Group, LLC | 1,462,699 | 30,234,000 | 19.69% | ||
| 2 | SCOPIA CAPITAL MANAGEMENT LP | 1,343,541 | 27,771,000 | 18.09% | ||
| 3 | Avoro Capital Advisors LLC | 1,103,093 | 22,801,000 | 14.85% | ||
| 4 | ACUTA CAPITAL PARTNERS, LLC | 496,630 | 10,265,000 | 6.69% | ||
| 5 | RA CAPITAL MANAGEMENT, L.P. | 425,000 | 8,785,000 | 5.72% | ||
| 6 | CADIAN CAPITAL MANAGEMENT, LP | 419,315 | 8,667,000 | 5.64% | ||
| 7 | ALPS ADVISORS INC | 33,687 | 6,963,000 | 4.53% | ||
| 8 | BAKER BROS. ADVISORS LP | 305,000 | 6,304,000 | 4.11% | ||
| 9 | PERCEPTIVE ADVISORS LLC | 270,000 | 5,581,000 | 3.63% | ||
| 10 | ArrowMark Colorado Holdings LLC | 124,290 | 2,569,000 | 1.67% | ||
| 11 | MENORA MIVTACHIM HOLDINGS LTD. | 109,826 | 2,270,000 | 1.48% | ||
| 12 | Ghost Tree Capital, LLC | 100,000 | 2,067,000 | 1.35% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 96,192 | 1,988,000 | 1.29% | ||
| 14 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 93,869 | 1,940,000 | 1.26% | ||
| 15 | ACADIAN ASSET MANAGEMENT LLC | 91,739 | 1,896,000 | 1.23% | ||
| 16 | SPHERA FUNDS MANAGEMENT LTD. | 85,000 | 1,757,000 | 1.14% | ||
| 17 | Foresite Capital Management II, LLC | 76,801 | 1,587,000 | 1.03% | ||
| 18 | AWM Investment Company, Inc. | 75,000 | 1,550,000 | 1.01% | ||
| 19 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 57,900 | 1,197,000 | 0.78% | Call | |
| 20 | D. E. Shaw & Co., Inc. | 57,786 | 1,194,000 | 0.78% | ||
| 21 | SENZAR ASSET MANAGEMENT, LLC | 56,000 | 1,157,520 | 0.75% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 42,500 | 878,000 | 0.57% | Put | |
| 23 | Informed Momentum Co LLC | 36,686 | 758,000 | 0.49% | ||
| 24 | MORGAN STANLEY | 33,562 | 694,000 | 0.45% | ||
| 25 | GLG LLC | 25,198 | 521,000 | 0.34% | ||
| 26 | Quantitative Systematic Strategies LLC | 20,564 | 425,000 | 0.28% | ||
| 27 | MENTA CAPITAL LLC | 18,310 | 378,000 | 0.25% | ||
| 28 | HighTower Advisors, LLC | 13,000 | 269,000 | 0.18% | ||
| 29 | SABBY MANAGEMENT, LLC | 12,416 | 257,000 | 0.17% | ||
| 30 | COWEN INC. | 10,100 | 209,000 | 0.14% | ||
| 31 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 9,991 | 207,000 | 0.13% | ||
| 32 | VAN ECK ASSOCIATES CORP | 7,158 | 148,000 | 0.10% | ||
| 33 | BANK OF AMERICA CORP /DE/ | 6,825 | 141,000 | 0.09% | ||
| 34 | UBS Group AG | 1,610 | 33,000 | 0.02% | ||
| 35 | EDMOND DE ROTHSCHILD HOLDING S.A. | 800 | 17,000 | 0.01% | ||
| 36 | EDMOND DE ROTHSCHILD (EUROPE) | 800 | 17,000 | 0.01% | ||
| 37 | ROYAL BANK OF CANADA | 700 | 14,000 | 0.01% | ||
| 38 | Tower Research Capital LLC (TRC) | 581 | 12,000 | 0.01% | ||
| 39 | MSI Financial Services Inc | 600 | 12,000 | 0.01% | ||
| 40 | Edge Wealth Management LLC | 500 | 10,000 | 0.01% | ||
| 41 | WELLS FARGO & COMPANY/MN | 205 | 4,000 | 0.00% | ||
| 42 | CITIGROUP INC | 5 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
