| 1 |
SCOPIA CAPITAL MANAGEMENT LP |
2,749,038 |
46,871,000 |
34.78% |
|
|
| 2 |
Redmile Group, LLC |
1,589,261 |
27,097,000 |
20.11% |
|
|
| 3 |
Avoro Capital Advisors LLC |
520,022 |
8,866,000 |
6.58% |
|
|
| 4 |
ACUTA CAPITAL PARTNERS, LLC |
477,300 |
8,138,000 |
6.04% |
|
|
| 5 |
BAKER BROS. ADVISORS LP |
305,000 |
5,200,000 |
3.86% |
|
|
| 6 |
PERCEPTIVE ADVISORS LLC |
270,000 |
4,604,000 |
3.42% |
|
|
| 7 |
BlackRock Fund Advisors |
265,237 |
4,522,000 |
3.36% |
|
|
| 8 |
FORESITE CAPITAL MANAGEMENT III, LLC |
261,945 |
4,466,000 |
3.31% |
|
|
| 9 |
ACADIAN ASSET MANAGEMENT LLC |
222,680 |
3,797,000 |
2.82% |
|
|
| 10 |
SENZAR ASSET MANAGEMENT, LLC |
201,700 |
3,438,985 |
2.55% |
|
|
| 11 |
RA CAPITAL MANAGEMENT, L.P. |
144,671 |
2,467,000 |
1.83% |
|
|
| 12 |
ArrowMark Colorado Holdings LLC |
130,972 |
2,233,000 |
1.66% |
|
|
| 13 |
GOLDMAN SACHS GROUP INC |
87,339 |
1,489,000 |
1.10% |
|
|
| 14 |
FOLGER HILL ASSET MANAGEMENT LP |
65,913 |
1,124,000 |
0.83% |
|
|
| 15 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
58,400 |
996,000 |
0.74% |
Put |
|
| 16 |
Foresite Capital Management II, LLC |
55,779 |
951,000 |
0.71% |
|
|
| 17 |
MORGAN STANLEY |
52,472 |
895,000 |
0.66% |
|
|
| 18 |
NEXTHERA CAPITAL LP |
48,000 |
818,000 |
0.61% |
|
|
| 19 |
MENTA CAPITAL LLC |
47,471 |
809,000 |
0.60% |
|
|
| 20 |
BOGLE INVESTMENT MANAGEMENT L P /DE/ |
44,321 |
755,000 |
0.56% |
|
|
| 21 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
40,000 |
682,000 |
0.51% |
|
|
| 22 |
DEUTSCHE BANK AG\ |
28,633 |
488,000 |
0.36% |
|
|
| 23 |
ALPS ADVISORS INC |
28,372 |
484,000 |
0.36% |
|
|
| 24 |
BlackRock Institutional Trust Company, N.A. |
27,837 |
475,000 |
0.35% |
|
|
| 25 |
Quantitative Systematic Strategies LLC |
18,124 |
307,000 |
0.23% |
|
|
| 26 |
ProShare Advisors LLC |
17,320 |
295,000 |
0.22% |
|
|
| 27 |
State of New Jersey Common Pension Fund D |
16,563 |
282,000 |
0.21% |
|
|
| 28 |
Spark Investment Management LLC |
15,500 |
264,000 |
0.20% |
|
|
| 29 |
D. E. Shaw & Co., Inc. |
14,652 |
250,000 |
0.19% |
|
|
| 30 |
Trexquant Investment LP |
12,798 |
218,000 |
0.16% |
|
|
| 31 |
HighTower Advisors, LLC |
12,150 |
207,000 |
0.15% |
|
|
| 32 |
BANK OF AMERICA CORP /DE/ |
10,892 |
185,000 |
0.14% |
|
|
| 33 |
CREDIT SUISSE AG/ |
10,662 |
182,000 |
0.14% |
|
|
| 34 |
COWEN INC. |
10,100 |
172,000 |
0.13% |
|
|
| 35 |
ROYAL BANK OF CANADA |
8,736 |
149,000 |
0.11% |
|
|
| 36 |
VAN ECK ASSOCIATES CORP |
6,879 |
117,000 |
0.09% |
|
|
| 37 |
Swiss National Bank |
5,700 |
97,000 |
0.07% |
|
|
| 38 |
BARCLAYS PLC |
4,968 |
84,000 |
0.06% |
|
|
| 39 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
4,676 |
80,000 |
0.06% |
|
|
| 40 |
CITIGROUP INC |
3,211 |
54,000 |
0.04% |
|
|
| 41 |
Focused Wealth Management, Inc |
1,575 |
27,000 |
0.02% |
|
|
| 42 |
UBS Group AG |
1,560 |
27,000 |
0.02% |
|
|
| 43 |
EDMOND DE ROTHSCHILD (EUROPE) |
1,600 |
27,000 |
0.02% |
|
|
| 44 |
EDMOND DE ROTHSCHILD HOLDING S.A. |
1,600 |
27,000 |
0.02% |
|
|
| 45 |
GROUP ONE TRADING LLC |
1,162 |
20,000 |
0.01% |
|
|
| 46 |
PENSERRA CAPITAL MANAGEMENT LLC |
820 |
14,000 |
0.01% |
|
|
| 47 |
HOWE & RUSLING INC |
250 |
4,000 |
0.00% |
|
|
| 48 |
WELLS FARGO & COMPANY/MN |
226 |
4,000 |
0.00% |
|
|
