| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | SCOPIA CAPITAL MANAGEMENT LP | 4,383,358 | 97,311,000 | 32.60% | ||
| 2 | Redmile Group, LLC | 1,560,819 | 34,650,000 | 11.61% | ||
| 3 | Avoro Capital Advisors LLC | 1,056,303 | 23,450,000 | 7.86% | ||
| 4 | ACUTA CAPITAL PARTNERS, LLC | 665,944 | 14,784,000 | 4.95% | ||
| 5 | MENORA MIVTACHIM HOLDINGS LTD. | 577,974 | 12,831,000 | 4.30% | ||
| 6 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 575,000 | 12,765,000 | 4.28% | ||
| 7 | BAKER BROS. ADVISORS LP | 571,667 | 12,691,000 | 4.25% | ||
| 8 | FRANKLIN RESOURCES INC | 500,000 | 11,100,000 | 3.72% | ||
| 9 | SECTORAL ASSET MANAGEMENT INC | 440,799 | 9,786,000 | 3.28% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 420,299 | 9,331,000 | 3.13% | ||
| 11 | Ghost Tree Capital, LLC | 330,000 | 7,326,000 | 2.45% | ||
| 12 | ArrowMark Colorado Holdings LLC | 317,411 | 7,047,000 | 2.36% | ||
| 13 | SENZAR ASSET MANAGEMENT, LLC | 186,800 | 4,147,000 | 1.39% | ||
| 14 | SPHERA FUNDS MANAGEMENT LTD. | 175,951 | 3,906,000 | 1.31% | ||
| 15 | Rhenman & Partners Asset Management AB | 142,546 | 3,165,000 | 1.06% | ||
| 16 | MENTA CAPITAL LLC | 110,896 | 2,462,000 | 0.82% | ||
| 17 | MONASHEE INVESTMENT MANAGEMENT LLC | 100,000 | 2,220,000 | 0.74% | ||
| 18 | BAILARD, INC. | 99,500 | 2,209,000 | 0.74% | ||
| 19 | Informed Momentum Co LLC | 81,642 | 1,812,000 | 0.61% | ||
| 20 | RENAISSANCE TECHNOLOGIES LLC | 80,942 | 1,797,000 | 0.60% | ||
| 21 | PURA VIDA INVESTMENTS, LLC | 80,183 | 1,780,000 | 0.60% | ||
| 22 | BlackRock Institutional Trust Company, N.A. | 79,352 | 1,762,000 | 0.59% | ||
| 23 | Opaleye Management Inc. | 115,000 | 1,731,000 | 0.58% | ||
| 24 | BlackRock Fund Advisors | 71,310 | 1,583,000 | 0.53% | ||
| 25 | STATE STREET CORP | 65,939 | 1,452,000 | 0.49% | ||
| 26 | INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 65,000 | 1,437,000 | 0.48% | ||
| 27 | PERCEPTIVE ADVISORS LLC | 57,825 | 1,284,000 | 0.43% | ||
| 28 | DEUTSCHE BANK AG\ | 57,276 | 1,270,000 | 0.43% | ||
| 29 | GOLDMAN SACHS GROUP INC | 50,000 | 1,110,000 | 0.37% | Put | |
| 30 | MOORE CAPITAL MANAGEMENT, LP | 50,000 | 1,110,000 | 0.37% | ||
| 31 | VICTORY CAPITAL MANAGEMENT INC | 46,630 | 1,035,000 | 0.35% | ||
| 32 | NORTHERN TRUST CORP | 38,403 | 853,000 | 0.29% | ||
| 33 | DAFNA Capital Management LLC | 37,921 | 842,000 | 0.28% | ||
| 34 | Swiss National Bank | 32,500 | 722,000 | 0.24% | ||
| 35 | D. E. Shaw & Co., Inc. | 27,176 | 603,000 | 0.20% | ||
| 36 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 23,089 | 513,000 | 0.17% | ||
| 37 | SABBY MANAGEMENT, LLC | 23,033 | 511,000 | 0.17% | ||
| 38 | PYRRHO CAPITAL MANAGEMENT, LP | 22,700 | 504,000 | 0.17% | ||
| 39 | ALPS ADVISORS INC | 20,766 | 461,000 | 0.15% | ||
| 40 | GOLDMAN SACHS GROUP INC | 20,729 | 460,000 | 0.15% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 20,600 | 457,000 | 0.15% | Put | |
| 42 | TIAA CREF INVESTMENT MANAGEMENT LLC | 19,498 | 433,000 | 0.15% | ||
| 43 | MORGAN STANLEY | 14,499 | 323,000 | 0.11% | ||
| 44 | CITADEL ADVISORS LLC | 13,200 | 293,000 | 0.10% | Put | |
| 45 | TUDOR INVESTMENT CORP ET AL | 10,000 | 222,000 | 0.07% | ||
| 46 | GEODE CAPITAL MANAGEMENT, LLC | 9,805 | 217,000 | 0.07% | ||
| 47 | BANK OF AMERICA CORP /DE/ | 8,563 | 190,000 | 0.06% | ||
| 48 | GROUP ONE TRADING LLC | 5,702 | 127,000 | 0.04% | ||
| 49 | PRELUDE CAPITAL MANAGEMENT, LLC | 5,283 | 117,000 | 0.04% | ||
| 50 | BARCLAYS PLC | 4,536 | 101,000 | 0.03% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
