| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | SCOPIA CAPITAL MANAGEMENT LP | 4,383,358 | 116,378,000 | 31.96% | ||
| 2 | Redmile Group, LLC | 924,304 | 24,540,000 | 6.74% | ||
| 3 | MENORA MIVTACHIM HOLDINGS LTD. | 681,556 | 18,095,000 | 4.97% | ||
| 4 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 675,000 | 17,921,000 | 4.92% | ||
| 5 | FRANKLIN RESOURCES INC | 636,000 | 16,886,000 | 4.64% | ||
| 6 | Avoro Capital Advisors LLC | 590,000 | 15,665,000 | 4.30% | ||
| 7 | BAKER BROS. ADVISORS LP | 571,667 | 15,178,000 | 4.17% | ||
| 8 | SECTORAL ASSET MANAGEMENT INC | 489,267 | 12,990,000 | 3.57% | ||
| 9 | ACUTA CAPITAL PARTNERS, LLC | 450,000 | 11,948,000 | 3.28% | ||
| 10 | SENZAR ASSET MANAGEMENT, LLC | 323,700 | 8,594,000 | 2.36% | ||
| 11 | GREAT POINT PARTNERS LLC | 314,724 | 8,356,000 | 2.29% | ||
| 12 | NEXTHERA CAPITAL LP | 288,000 | 7,646,000 | 2.10% | ||
| 13 | OppenheimerFunds, Inc. | 285,792 | 7,588,000 | 2.08% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 264,571 | 7,024,000 | 1.93% | ||
| 15 | ArrowMark Colorado Holdings LLC | 264,296 | 7,017,000 | 1.93% | ||
| 16 | FMR LLC | 200,000 | 5,310,000 | 1.46% | ||
| 17 | CRAWFORD LAKE CAPITAL MANAGEMENT, LLC | 191,676 | 5,089,000 | 1.40% | ||
| 18 | ACUTA CAPITAL PARTNERS, LLC | 150,000 | 3,983,000 | 1.09% | Call | |
| 19 | BlackRock Finance, Inc. | 149,477 | 3,968,000 | 1.09% | ||
| 20 | CITADEL ADVISORS LLC | 124,575 | 3,308,000 | 0.91% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 120,100 | 3,189,000 | 0.88% | Call | |
| 22 | Opaleye Management Inc. | 120,000 | 3,186,000 | 0.87% | ||
| 23 | BAILARD, INC. | 109,000 | 2,894,000 | 0.79% | ||
| 24 | INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 108,248 | 2,869,000 | 0.79% | ||
| 25 | PURA VIDA INVESTMENTS, LLC | 103,850 | 2,757,000 | 0.76% | ||
| 26 | Rock Springs Capital Management LP | 84,079 | 2,232,000 | 0.61% | ||
| 27 | Informed Momentum Co LLC | 81,642 | 2,168,000 | 0.60% | ||
| 28 | RENAISSANCE TECHNOLOGIES LLC | 79,626 | 2,114,000 | 0.58% | ||
| 29 | D. E. Shaw & Co., Inc. | 67,391 | 1,789,000 | 0.49% | ||
| 30 | HIGHLAND CAPITAL MANAGEMENT LP | 60,000 | 1,593,000 | 0.44% | ||
| 31 | GOLDMAN SACHS GROUP INC | 57,500 | 1,527,000 | 0.42% | Put | |
| 32 | NORTHERN TRUST CORP | 54,728 | 1,453,000 | 0.40% | ||
| 33 | CRAWFORD LAKE CAPITAL MANAGEMENT, LLC | 50,000 | 1,275,000 | 0.35% | Call | |
| 34 | STATE STREET CORP | 47,215 | 1,254,000 | 0.34% | ||
| 35 | BALYASNY ASSET MANAGEMENT L.P. | 43,200 | 1,147,000 | 0.31% | ||
| 36 | VICTORY CAPITAL MANAGEMENT INC | 42,581 | 1,131,000 | 0.31% | ||
| 37 | GROUP ONE TRADING LLC | 41,083 | 1,091,000 | 0.30% | ||
| 38 | Lombard Odier Asset Management (USA) Corp | 40,000 | 1,062,000 | 0.29% | ||
| 39 | DAFNA Capital Management LLC | 37,438 | 994,000 | 0.27% | ||
| 40 | DEUTSCHE BANK AG\ | 32,681 | 866,000 | 0.24% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 31,765 | 843,000 | 0.23% | ||
| 42 | Swiss National Bank | 30,400 | 807,000 | 0.22% | ||
| 43 | Calamos Advisors LLC | 26,900 | 714,000 | 0.20% | ||
| 44 | Artal Group S.A. | 25,000 | 664,000 | 0.18% | ||
| 45 | MENTA CAPITAL LLC | 24,876 | 660,000 | 0.18% | ||
| 46 | TIAA CREF INVESTMENT MANAGEMENT LLC | 22,400 | 595,000 | 0.16% | ||
| 47 | ALPS ADVISORS INC | 22,657 | 587,000 | 0.16% | ||
| 48 | Crestline Management, LP | 18,000 | 478,000 | 0.13% | ||
| 49 | Connor, Clark & Lunn Investment Management Ltd. | 15,912 | 422,000 | 0.12% | ||
| 50 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 15,816 | 420,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
