| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Abingworth LLP | 2,017,872 | 20,340,000 | 23.17% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,265,343 | 13,160,000 | 14.99% | ||
| 3 | RA CAPITAL MANAGEMENT, L.P. | 1,250,000 | 13,000,000 | 14.81% | ||
| 4 | MPM ASSET MANAGEMENT LLC | 983,381 | 10,227,000 | 11.65% | ||
| 5 | FMR LLC | 850,000 | 8,840,000 | 10.07% | ||
| 6 | TIVERTON ASSET MANAGEMENT LLC | 375,000 | 3,900,000 | 4.44% | ||
| 7 | Devon Park Associates, LLC | 325,727 | 3,388,000 | 3.86% | ||
| 8 | Deer VII & Co. Ltd. | 315,101 | 2,949,000 | 3.36% | ||
| 9 | PERCEPTIVE ADVISORS LLC | 275,000 | 2,860,000 | 3.26% | ||
| 10 | Omega Fund Management, LLC | 250,000 | 2,600,000 | 2.96% | ||
| 11 | VANGUARD GROUP INC | 189,720 | 1,973,000 | 2.25% | ||
| 12 | BAKER BROS. ADVISORS LP | 172,917 | 1,798,000 | 2.05% | ||
| 13 | PRINCIPAL FINANCIAL GROUP INC | 167,200 | 1,739,000 | 1.98% | ||
| 14 | Alyeska Investment Group, L.P. | 46,295 | 481,000 | 0.55% | ||
| 15 | KORNITZER CAPITAL MANAGEMENT INC /KS | 15,000 | 156,000 | 0.18% | ||
| 16 | DAFNA Capital Management LLC | 12,700 | 132,000 | 0.15% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 10,992 | 114,000 | 0.13% | ||
| 18 | DEUTSCHE BANK AG\ | 8,573 | 89,000 | 0.10% | ||
| 19 | BlackRock Investment Management, LLC | 1,150 | 12,000 | 0.01% | ||
| 20 | UBS Group AG | 1,114 | 12,000 | 0.01% | ||
| 21 | American Research & Management Co. | 1,000 | 10,000 | 0.01% | ||
| 22 | MORGAN STANLEY | 528 | 5,000 | 0.01% | ||
| 23 | BANK OF AMERICA CORP /DE/ | 100 | 1,000 | 0.00% | ||
| 24 | Tower Research Capital LLC (TRC) | 100 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
