| 1 |
Abingworth LLP |
2,017,872 |
31,277,000 |
22.23% |
|
|
| 2 |
RA CAPITAL MANAGEMENT, L.P. |
1,476,931 |
22,907,000 |
16.28% |
|
|
| 3 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
1,265,343 |
19,625,000 |
13.95% |
|
|
| 4 |
MPM ASSET MANAGEMENT LLC |
983,381 |
15,252,000 |
10.84% |
|
|
| 5 |
FMR LLC |
850,000 |
13,184,000 |
9.37% |
|
|
| 6 |
Deer VII & Co. Ltd. |
315,101 |
4,887,000 |
3.47% |
|
|
| 7 |
TIVERTON ASSET MANAGEMENT LLC |
304,303 |
4,720,000 |
3.35% |
|
|
| 8 |
BAKER BROS. ADVISORS LP |
298,591 |
4,631,000 |
3.29% |
|
|
| 9 |
PERCEPTIVE ADVISORS LLC |
275,000 |
4,265,000 |
3.03% |
|
|
| 10 |
Omega Fund Management, LLC |
250,000 |
3,878,000 |
2.76% |
|
|
| 11 |
BlackRock Fund Advisors |
204,638 |
3,174,000 |
2.26% |
|
|
| 12 |
PRINCIPAL FINANCIAL GROUP INC |
190,446 |
2,954,000 |
2.10% |
|
|
| 13 |
VANGUARD GROUP INC |
148,596 |
2,305,000 |
1.64% |
|
|
| 14 |
NORTHERN TRUST CORP |
79,438 |
1,232,000 |
0.88% |
|
|
| 15 |
MONASHEE INVESTMENT MANAGEMENT LLC |
63,082 |
978,000 |
0.70% |
|
|
| 16 |
STATE STREET CORP |
59,480 |
924,000 |
0.66% |
|
|
| 17 |
BlackRock Institutional Trust Company, N.A. |
52,196 |
810,000 |
0.58% |
|
|
| 18 |
GEODE CAPITAL MANAGEMENT, LLC |
42,727 |
662,000 |
0.47% |
|
|
| 19 |
BlackRock Investment Management, LLC |
25,533 |
396,000 |
0.28% |
|
|
| 20 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
19,844 |
308,000 |
0.22% |
|
|
| 21 |
Bank of New York Mellon Corp |
19,722 |
306,000 |
0.22% |
|
|
| 22 |
MERITAGE PORTFOLIO MANAGEMENT |
14,289 |
222,000 |
0.16% |
|
|
| 23 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
14,279 |
221,000 |
0.16% |
|
|
| 24 |
KORNITZER CAPITAL MANAGEMENT INC /KS |
12,000 |
186,000 |
0.13% |
|
|
| 25 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
11,835 |
184,000 |
0.13% |
|
|
| 26 |
PILLAR PACIFIC CAPITAL MANAGEMENT LLC |
11,499 |
178,000 |
0.13% |
|
|
| 27 |
TEACHERS ADVISORS, LLC |
11,296 |
175,000 |
0.12% |
|
|
| 28 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
10,998 |
171,000 |
0.12% |
|
|
| 29 |
NEW YORK STATE COMMON RETIREMENT FUND |
7,100 |
110,000 |
0.08% |
|
|
| 30 |
MORGAN STANLEY |
6,807 |
106,000 |
0.08% |
|
|
| 31 |
Nationwide Fund Advisors |
4,815 |
75,000 |
0.05% |
|
|
| 32 |
AMERICAN INTERNATIONAL GROUP, INC. |
4,515 |
70,000 |
0.05% |
|
|
| 33 |
Tower Research Capital LLC (TRC) |
3,906 |
61,000 |
0.04% |
|
|
| 34 |
STRS OHIO |
3,700 |
57,000 |
0.04% |
|
|
| 35 |
BLACKROCK ADVISORS LLC |
3,365 |
52,000 |
0.04% |
|
|
| 36 |
CITIGROUP INC |
2,326 |
36,000 |
0.03% |
|
|
| 37 |
DEUTSCHE BANK AG\ |
1,904 |
29,000 |
0.02% |
|
|
| 38 |
FULLER & THALER ASSET MANAGEMENT, INC. |
1,700 |
26,000 |
0.02% |
|
|
| 39 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
1,547 |
24,000 |
0.02% |
|
|
| 40 |
UBS Group AG |
1,117 |
17,000 |
0.01% |
|
|
| 41 |
American Research & Management Co. |
1,000 |
16,000 |
0.01% |
|
|
| 42 |
WELLS FARGO & COMPANY/MN |
775 |
12,000 |
0.01% |
|
|
| 43 |
BNP PARIBAS FINANCIAL MARKETS |
683 |
10,593 |
0.01% |
|
|
| 44 |
BANK OF AMERICA CORP /DE/ |
186 |
3,000 |
0.00% |
|
|
| 45 |
HOWE & RUSLING INC |
50 |
1,000 |
0.00% |
|
|
