| 1 |
Abingworth LLP |
2,017,872 |
27,423,000 |
21.71% |
|
|
| 2 |
RA CAPITAL MANAGEMENT, L.P. |
1,506,872 |
20,961,000 |
16.59% |
|
|
| 3 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
1,265,343 |
17,601,000 |
13.93% |
|
|
| 4 |
MPM ASSET MANAGEMENT LLC |
983,381 |
13,679,000 |
10.83% |
|
|
| 5 |
FMR LLC |
850,000 |
11,824,000 |
9.36% |
|
|
| 6 |
TIVERTON ASSET MANAGEMENT LLC |
375,000 |
5,216,000 |
4.13% |
|
|
| 7 |
Deer VII & Co. Ltd. |
315,101 |
4,383,000 |
3.47% |
|
|
| 8 |
PERCEPTIVE ADVISORS LLC |
275,000 |
3,825,000 |
3.03% |
|
|
| 9 |
BAKER BROS. ADVISORS LP |
274,617 |
3,820,000 |
3.02% |
|
|
| 10 |
Omega Fund Management, LLC |
250,000 |
3,478,000 |
2.75% |
|
|
| 11 |
BlackRock Fund Advisors |
199,223 |
2,771,000 |
2.19% |
|
|
| 12 |
PRINCIPAL FINANCIAL GROUP INC |
182,698 |
2,542,000 |
2.01% |
|
|
| 13 |
VANGUARD GROUP INC |
146,018 |
2,031,000 |
1.61% |
|
|
| 14 |
NORTHERN TRUST CORP |
77,707 |
1,081,000 |
0.86% |
|
|
| 15 |
MONASHEE INVESTMENT MANAGEMENT LLC |
77,102 |
1,072,000 |
0.85% |
|
|
| 16 |
STATE STREET CORP |
54,572 |
758,000 |
0.60% |
|
|
| 17 |
BlackRock Institutional Trust Company, N.A. |
50,289 |
700,000 |
0.55% |
|
|
| 18 |
GEODE CAPITAL MANAGEMENT, LLC |
41,690 |
579,000 |
0.46% |
|
|
| 19 |
BlackRock Investment Management, LLC |
25,365 |
353,000 |
0.28% |
|
|
| 20 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
19,844 |
276,000 |
0.22% |
|
|
| 21 |
Bank of New York Mellon Corp |
19,722 |
274,000 |
0.22% |
|
|
| 22 |
MERITAGE PORTFOLIO MANAGEMENT |
14,289 |
199,000 |
0.16% |
|
|
| 23 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
14,079 |
196,000 |
0.16% |
|
|
| 24 |
KORNITZER CAPITAL MANAGEMENT INC /KS |
12,000 |
167,000 |
0.13% |
|
|
| 25 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
11,835 |
165,000 |
0.13% |
|
|
| 26 |
PILLAR PACIFIC CAPITAL MANAGEMENT LLC |
11,499 |
159,000 |
0.13% |
|
|
| 27 |
TEACHERS ADVISORS, LLC |
11,296 |
157,000 |
0.12% |
|
|
| 28 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
10,998 |
153,000 |
0.12% |
|
|
| 29 |
NEW YORK STATE COMMON RETIREMENT FUND |
7,100 |
99,000 |
0.08% |
|
|
| 30 |
BLACKROCK ADVISORS LLC |
5,094 |
71,000 |
0.06% |
|
|
| 31 |
Nationwide Fund Advisors |
4,815 |
67,000 |
0.05% |
|
|
| 32 |
AMERICAN INTERNATIONAL GROUP, INC. |
4,523 |
63,000 |
0.05% |
|
|
| 33 |
MORGAN STANLEY |
3,066 |
43,000 |
0.03% |
|
|
| 34 |
STRS OHIO |
2,500 |
34,000 |
0.03% |
|
|
| 35 |
DEUTSCHE BANK AG\ |
2,125 |
29,000 |
0.02% |
|
|
| 36 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
1,547 |
22,000 |
0.02% |
|
|
| 37 |
BNP PARIBAS FINANCIAL MARKETS |
1,529 |
21,268 |
0.02% |
|
|
| 38 |
American Research & Management Co. |
1,000 |
14,000 |
0.01% |
|
|
| 39 |
ROYAL BANK OF CANADA |
776 |
11,000 |
0.01% |
|
|
| 40 |
UBS Group AG |
299 |
4,000 |
0.00% |
|
|
| 41 |
BARCLAYS PLC |
40 |
1,000 |
0.00% |
|
|
| 42 |
HOWE & RUSLING INC |
50 |
1,000 |
0.00% |
|
|
| 43 |
WELLS FARGO & COMPANY/MN |
45 |
1,000 |
0.00% |
|
|
| 44 |
BANK OF AMERICA CORP /DE/ |
27 |
0 |
0.00% |
|
|
| 45 |
CITIGROUP INC |
1 |
0 |
0.00% |
|
|
