| 1 |
Abingworth LLP |
2,017,872 |
36,039,000 |
22.39% |
|
|
| 2 |
RA CAPITAL MANAGEMENT, L.P. |
1,506,872 |
26,913,000 |
16.72% |
|
|
| 3 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
1,265,343 |
22,599,000 |
14.04% |
|
|
| 4 |
MPM ASSET MANAGEMENT LLC |
983,381 |
17,563,000 |
10.91% |
|
|
| 5 |
FMR LLC |
850,000 |
15,181,000 |
9.43% |
|
|
| 6 |
TIVERTON ASSET MANAGEMENT LLC |
375,000 |
6,698,000 |
4.16% |
|
|
| 7 |
Deer VII & Co. Ltd. |
315,101 |
5,628,000 |
3.50% |
|
|
| 8 |
PERCEPTIVE ADVISORS LLC |
275,000 |
4,912,000 |
3.05% |
|
|
| 9 |
Omega Fund Management, LLC |
250,000 |
4,465,000 |
2.77% |
|
|
| 10 |
BlackRock Fund Advisors |
193,203 |
3,451,000 |
2.14% |
|
|
| 11 |
PRINCIPAL FINANCIAL GROUP INC |
180,217 |
3,219,000 |
2.00% |
|
|
| 12 |
BAKER BROS. ADVISORS LP |
176,762 |
3,157,000 |
1.96% |
|
|
| 13 |
VANGUARD GROUP INC |
174,925 |
3,125,000 |
1.94% |
|
|
| 14 |
MONASHEE INVESTMENT MANAGEMENT LLC |
77,102 |
1,377,000 |
0.86% |
|
PRN |
| 15 |
STATE STREET CORP |
47,254 |
844,000 |
0.52% |
|
|
| 16 |
BlackRock Institutional Trust Company, N.A. |
42,522 |
759,000 |
0.47% |
|
|
| 17 |
GEODE CAPITAL MANAGEMENT, LLC |
40,482 |
723,000 |
0.45% |
|
|
| 18 |
BlackRock Investment Management, LLC |
25,835 |
461,000 |
0.29% |
|
|
| 19 |
Bank of New York Mellon Corp |
21,477 |
383,000 |
0.24% |
|
|
| 20 |
TFS CAPITAL LLC |
21,126 |
377,000 |
0.23% |
|
|
| 21 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
19,844 |
354,000 |
0.22% |
|
|
| 22 |
NORTHERN TRUST CORP |
16,576 |
296,000 |
0.18% |
|
|
| 23 |
Spark Investment Management LLC |
15,100 |
269,000 |
0.17% |
|
|
| 24 |
KORNITZER CAPITAL MANAGEMENT INC /KS |
15,000 |
268,000 |
0.17% |
|
|
| 25 |
MERITAGE PORTFOLIO MANAGEMENT |
14,289 |
255,000 |
0.16% |
|
|
| 26 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
14,079 |
251,000 |
0.16% |
|
|
| 27 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
11,835 |
211,000 |
0.13% |
|
|
| 28 |
PILLAR PACIFIC CAPITAL MANAGEMENT LLC |
11,499 |
205,000 |
0.13% |
|
|
| 29 |
TEACHERS ADVISORS, LLC |
11,296 |
202,000 |
0.13% |
|
|
| 30 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
10,998 |
197,000 |
0.12% |
|
|
| 31 |
MORGAN STANLEY |
6,968 |
124,000 |
0.08% |
|
|
| 32 |
Nationwide Fund Advisors |
4,815 |
86,000 |
0.05% |
|
|
| 33 |
BLACKROCK ADVISORS LLC |
4,557 |
81,000 |
0.05% |
|
|
| 34 |
AMERICAN INTERNATIONAL GROUP, INC. |
4,518 |
80,691 |
0.05% |
|
|
| 35 |
RUSSELL FRANK CO/ |
2,700 |
48,000 |
0.03% |
|
|
| 36 |
STRS OHIO |
2,500 |
44,000 |
0.03% |
|
|
| 37 |
DEUTSCHE BANK AG\ |
1,852 |
33,000 |
0.02% |
|
|
| 38 |
NEW YORK STATE COMMON RETIREMENT FUND |
1,800 |
32,000 |
0.02% |
|
|
| 39 |
American Research & Management Co. |
1,000 |
18,000 |
0.01% |
|
|
| 40 |
Tower Research Capital LLC (TRC) |
833 |
15,000 |
0.01% |
|
|
| 41 |
BNP PARIBAS FINANCIAL MARKETS |
641 |
11,448 |
0.01% |
|
|
| 42 |
UBS Group AG |
549 |
10,000 |
0.01% |
|
|
| 43 |
ROYAL BANK OF CANADA |
475 |
8,000 |
0.00% |
|
|
| 44 |
WELLS FARGO & COMPANY/MN |
386 |
7,000 |
0.00% |
|
|
| 45 |
Invesco Ltd. |
341 |
6,000 |
0.00% |
|
|
| 46 |
BANK OF AMERICA CORP /DE/ |
213 |
4,000 |
0.00% |
|
|
| 47 |
BARCLAYS PLC |
147 |
2,000 |
0.00% |
|
|
| 48 |
CITIGROUP INC |
100 |
2,000 |
0.00% |
|
|
| 49 |
HOWE & RUSLING INC |
50 |
1,000 |
0.00% |
|
|
