| 1 |
Abingworth LLP |
2,017,872 |
3,632,000 |
27.55% |
|
|
| 2 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
1,332,599 |
2,532,000 |
19.21% |
|
|
| 3 |
PHARMSTANDARD INTERNATIONAL S.A. |
1,165,344 |
2,214,000 |
16.79% |
|
|
| 4 |
MPM ASSET MANAGEMENT LLC |
983,381 |
1,868,000 |
14.17% |
|
|
| 5 |
BAKER BROS. ADVISORS LP |
389,394 |
740,000 |
5.61% |
|
|
| 6 |
PERCEPTIVE ADVISORS LLC |
334,116 |
635,000 |
4.82% |
|
|
| 7 |
Deer VII & Co. Ltd. |
315,101 |
599,000 |
4.54% |
|
|
| 8 |
VANGUARD GROUP INC |
191,361 |
363,000 |
2.75% |
|
|
| 9 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
58,986 |
112,000 |
0.85% |
|
|
| 10 |
FINANCIAL COUNSELORS INC |
50,000 |
95,000 |
0.72% |
|
|
| 11 |
GEODE CAPITAL MANAGEMENT, LLC |
37,569 |
71,000 |
0.54% |
|
|
| 12 |
Virtu KCG Holdings LLC |
31,647 |
60,000 |
0.46% |
|
|
| 13 |
RENAISSANCE TECHNOLOGIES LLC |
30,500 |
58,000 |
0.44% |
|
|
| 14 |
BlackRock Fund Advisors |
23,115 |
44,000 |
0.33% |
|
|
| 15 |
WEDBUSH SECURITIES INC |
17,000 |
32,000 |
0.24% |
|
|
| 16 |
NORTHERN TRUST CORP |
13,512 |
26,000 |
0.20% |
|
|
| 17 |
KORNITZER CAPITAL MANAGEMENT INC /KS |
12,000 |
23,000 |
0.17% |
|
|
| 18 |
ROYAL BANK OF CANADA |
12,090 |
23,000 |
0.17% |
|
|
| 19 |
PILLAR PACIFIC CAPITAL MANAGEMENT LLC |
11,499 |
21,000 |
0.16% |
|
|
| 20 |
Mariner, LLC |
11,125 |
21,000 |
0.16% |
|
|
| 21 |
UBS Group AG |
2,782 |
5,000 |
0.04% |
|
|
| 22 |
Tower Research Capital LLC (TRC) |
1,490 |
3,000 |
0.02% |
|
|
| 23 |
BLACKROCK ADVISORS LLC |
1,374 |
3,000 |
0.02% |
|
|
| 24 |
BlackRock Investment Management, LLC |
1,366 |
3,000 |
0.02% |
|
|
| 25 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
536 |
1,000 |
0.01% |
|
|
| 26 |
Omega Fund Management, LLC |
0 |
0 |
0.00% |
|
|
