| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Abingworth LLP | 2,017,872 | 22,661,000 | 22.93% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,265,343 | 14,716,000 | 14.89% | ||
| 3 | RA CAPITAL MANAGEMENT, L.P. | 1,250,000 | 14,538,000 | 14.71% | ||
| 4 | MPM ASSET MANAGEMENT LLC | 983,381 | 11,437,000 | 11.57% | ||
| 5 | FMR LLC | 850,000 | 9,886,000 | 10.00% | ||
| 6 | TIVERTON ASSET MANAGEMENT LLC | 375,000 | 4,361,000 | 4.41% | ||
| 7 | Devon Park Associates, LLC | 325,727 | 3,788,000 | 3.83% | ||
| 8 | Deer VII & Co. Ltd. | 315,101 | 3,298,000 | 3.34% | ||
| 9 | PERCEPTIVE ADVISORS LLC | 275,000 | 3,198,000 | 3.24% | ||
| 10 | Omega Fund Management, LLC | 250,000 | 2,907,000 | 2.94% | ||
| 11 | VANGUARD GROUP INC | 205,010 | 2,384,000 | 2.41% | ||
| 12 | BAKER BROS. ADVISORS LP | 172,917 | 2,011,000 | 2.03% | ||
| 13 | PRINCIPAL FINANCIAL GROUP INC | 168,100 | 1,956,000 | 1.98% | ||
| 14 | MONASHEE INVESTMENT MANAGEMENT LLC | 82,902 | 964,000 | 0.98% | ||
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 22,891 | 266,000 | 0.27% | ||
| 16 | KORNITZER CAPITAL MANAGEMENT INC /KS | 15,000 | 174,000 | 0.18% | ||
| 17 | PILLAR PACIFIC CAPITAL MANAGEMENT LLC | 11,499 | 134,000 | 0.14% | ||
| 18 | CREDIT SUISSE AG/ | 10,000 | 116,000 | 0.12% | ||
| 19 | BlackRock Investment Management, LLC | 1,145 | 13,000 | 0.01% | ||
| 20 | American Research & Management Co. | 1,000 | 12,000 | 0.01% | ||
| 21 | MORGAN STANLEY | 300 | 3,000 | 0.00% | ||
| 22 | Tower Research Capital LLC (TRC) | 192 | 2,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
