| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | TIVERTON ASSET MANAGEMENT LLC | 497,959 | 28,229,000 | 30.35% | ||
| 2 | Abingworth LLP | 2,017,872 | 16,264,000 | 17.48% | ||
| 3 | RA CAPITAL MANAGEMENT, L.P. | 1,626,931 | 13,064,000 | 14.04% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,552,031 | 12,463,000 | 13.40% | ||
| 5 | MPM ASSET MANAGEMENT LLC | 983,381 | 7,897,000 | 8.49% | ||
| 6 | Deer VII & Co. Ltd. | 315,101 | 2,530,000 | 2.72% | ||
| 7 | BAKER BROS. ADVISORS LP | 298,591 | 2,398,000 | 2.58% | ||
| 8 | PERCEPTIVE ADVISORS LLC | 275,000 | 2,208,000 | 2.37% | ||
| 9 | Omega Fund Management, LLC | 250,000 | 2,008,000 | 2.16% | ||
| 10 | PRINCIPAL FINANCIAL GROUP INC | 185,649 | 1,491,000 | 1.60% | ||
| 11 | FMR LLC | 157,421 | 1,264,000 | 1.36% | ||
| 12 | VANGUARD GROUP INC | 134,241 | 1,078,000 | 1.16% | ||
| 13 | GEODE CAPITAL MANAGEMENT, LLC | 37,184 | 298,000 | 0.32% | ||
| 14 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 36,835 | 296,000 | 0.32% | ||
| 15 | Paloma Partners Management Co | 29,128 | 234,000 | 0.25% | ||
| 16 | TFS CAPITAL LLC | 25,665 | 206,000 | 0.22% | ||
| 17 | BlackRock Fund Advisors | 22,431 | 180,000 | 0.19% | ||
| 18 | MILLENNIUM MANAGEMENT LLC | 15,445 | 124,000 | 0.13% | ||
| 19 | MONASHEE INVESTMENT MANAGEMENT LLC | 14,615 | 117,000 | 0.13% | PRN | |
| 20 | MERITAGE PORTFOLIO MANAGEMENT | 14,289 | 115,000 | 0.12% | ||
| 21 | BAIRD FINANCIAL GROUP, INC. | 13,436 | 108,000 | 0.12% | ||
| 22 | NORTHERN TRUST CORP | 13,083 | 105,000 | 0.11% | ||
| 23 | KORNITZER CAPITAL MANAGEMENT INC /KS | 12,000 | 96,000 | 0.10% | ||
| 24 | PILLAR PACIFIC CAPITAL MANAGEMENT LLC | 11,499 | 92,000 | 0.10% | ||
| 25 | DEUTSCHE BANK AG\ | 6,430 | 51,000 | 0.05% | ||
| 26 | BANK OF AMERICA CORP /DE/ | 4,269 | 34,000 | 0.04% | ||
| 27 | MORGAN STANLEY | 3,124 | 25,000 | 0.03% | ||
| 28 | Tower Research Capital LLC (TRC) | 2,300 | 18,000 | 0.02% | ||
| 29 | BLACKROCK ADVISORS LLC | 1,374 | 11,000 | 0.01% | ||
| 30 | BlackRock Investment Management, LLC | 1,366 | 11,000 | 0.01% | ||
| 31 | CITIGROUP INC | 600 | 5,000 | 0.01% | ||
| 32 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 536 | 4,000 | 0.00% | ||
| 33 | HOWE & RUSLING INC | 50 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
