| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 2,949,794 | 11,799,000 | 36.12% | ||
| 2 | Capital World Investors | 1,429,000 | 5,716,000 | 17.50% | ||
| 3 | PERCEPTIVE ADVISORS LLC | 723,853 | 2,895,000 | 8.86% | ||
| 4 | ORBIMED ADVISORS LLC | 634,812 | 2,539,000 | 7.77% | ||
| 5 | Alyeska Investment Group, L.P. | 439,894 | 1,760,000 | 5.39% | ||
| 6 | Invesco Private Capital, Inc. | 380,784 | 1,523,000 | 4.66% | ||
| 7 | Tekla Capital Management LLC | 350,000 | 1,400,000 | 4.29% | ||
| 8 | DAFNA Capital Management LLC | 339,614 | 1,358,000 | 4.16% | ||
| 9 | RENAISSANCE TECHNOLOGIES LLC | 217,090 | 868,000 | 2.66% | ||
| 10 | Artal Group S.A. | 150,000 | 600,000 | 1.84% | ||
| 11 | Novo Holdings A/S | 127,563 | 510,000 | 1.56% | ||
| 12 | K2 PRINCIPAL FUND, L.P. | 116,975 | 468,000 | 1.43% | ||
| 13 | J. Goldman & Co LP | 72,400 | 290,000 | 0.89% | ||
| 14 | ROYAL BANK OF CANADA | 56,173 | 225,000 | 0.69% | ||
| 15 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 55,000 | 220,000 | 0.67% | ||
| 16 | Weiss Multi-Strategy Advisers LLC | 31,500 | 126,000 | 0.39% | ||
| 17 | SCOTIA CAPITAL INC. | 26,203 | 105,000 | 0.32% | ||
| 18 | LEITH WHEELER INVESTMENT COUNSEL LTD. | 16,075 | 64,000 | 0.20% | ||
| 19 | DEUTSCHE BANK AG\ | 12,737 | 50,000 | 0.15% | ||
| 20 | A.R.T. Advisors, LLC | 12,500 | 50,000 | 0.15% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 10,386 | 41,000 | 0.13% | ||
| 22 | BANK OF MONTREAL /CAN/ | 7,137 | 29,000 | 0.09% | ||
| 23 | JPMORGAN CHASE & CO | 3,616 | 14,000 | 0.04% | ||
| 24 | WELLS FARGO & COMPANY/MN | 2,464 | 10,000 | 0.03% | ||
| 25 | MORGAN STANLEY | 1,055 | 4,000 | 0.01% | ||
| 26 | CITIGROUP INC | 700 | 3,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
