| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JANUS HENDERSON INVESTORS US LLC | 1,984,363 | 46,355,000 | 20.18% | ||
| 2 | FMR LLC | 1,536,565 | 35,895,000 | 15.63% | ||
| 3 | BAKER BROS. ADVISORS LP | 1,519,229 | 35,489,000 | 15.45% | ||
| 4 | ALLIANCEBERNSTEIN L.P. | 879,950 | 20,556,000 | 8.95% | ||
| 5 | Invesco Ltd. | 770,629 | 18,002,000 | 7.84% | ||
| 6 | JENNISON ASSOCIATES LLC | 628,712 | 14,687,000 | 6.39% | ||
| 7 | Visium Asset Management, LP | 464,405 | 10,849,000 | 4.72% | ||
| 8 | Point72 Asset Management, L.P. | 385,000 | 8,994,000 | 3.92% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 375,861 | 8,780,000 | 3.82% | ||
| 10 | DEERFIELD MANAGEMENT COMPANY, L.P. | 298,121 | 6,964,000 | 3.03% | ||
| 11 | Asset Management One Co., Ltd. | 286,338 | 6,654,000 | 2.90% | ||
| 12 | Ghost Tree Capital, LLC | 150,000 | 3,504,000 | 1.53% | ||
| 13 | JPMORGAN CHASE & CO | 119,869 | 2,800,000 | 1.22% | ||
| 14 | DEUTSCHE BANK AG\ | 116,365 | 2,718,000 | 1.18% | ||
| 15 | EVENTIDE ASSET MANAGEMENT, LLC | 96,400 | 2,252,000 | 0.98% | ||
| 16 | MORGAN STANLEY | 56,799 | 1,327,000 | 0.58% | ||
| 17 | BLUE ARROW CAPITAL MANAGEMENT LLC | 55,000 | 1,285,000 | 0.56% | ||
| 18 | Iguana Healthcare Management, LLC | 45,000 | 1,051,000 | 0.46% | ||
| 19 | CITIGROUP INC | 37,295 | 871,000 | 0.38% | ||
| 20 | GAM Holding AG | 26,800 | 626,000 | 0.27% | ||
| 21 | UBS Group AG | 1,478 | 35,000 | 0.02% | ||
| 22 | MANAGED ACCOUNT ADVISORS LLC | 25 | 1,000 | 0.00% | ||
| 23 | TCI Wealth Advisors, Inc. | 20 | 0 | 0.00% | ||
| 24 | PERCEPTIVE ADVISORS LLC | 2 | 0 | 0.00% | ||
| 25 | WELLS FARGO & COMPANY/MN | 19 | 0 | 0.00% | ||
| 26 | BANK OF AMERICA CORP /DE/ | 15 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
