| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 5,462,019 | 194,393,000 | 24.56% | ||
| 2 | FMR LLC | 4,096,094 | 145,779,000 | 18.41% | ||
| 3 | JANUS HENDERSON INVESTORS US LLC | 3,320,157 | 118,167,000 | 14.93% | ||
| 4 | ALLIANCEBERNSTEIN L.P. | 1,052,351 | 37,453,000 | 4.73% | ||
| 5 | TimesSquare Capital Management, LLC | 993,438 | 35,356,000 | 4.47% | ||
| 6 | Invesco Ltd. | 754,588 | 26,856,000 | 3.39% | ||
| 7 | GILDER GAGNON HOWE & CO LLC | 725,503 | 25,821,000 | 3.26% | ||
| 8 | JENNISON ASSOCIATES LLC | 715,197 | 25,454,000 | 3.22% | ||
| 9 | Redmile Group, LLC | 532,818 | 18,963,000 | 2.40% | ||
| 10 | Visium Asset Management, LP | 515,163 | 18,335,000 | 2.32% | ||
| 11 | RS INVESTMENT MANAGEMENT CO LLC | 494,640 | 17,604,000 | 2.22% | ||
| 12 | DEERFIELD MANAGEMENT COMPANY, L.P. | 461,869 | 16,438,000 | 2.08% | ||
| 13 | FIRST MANHATTAN CO. LLC. | 313,422 | 11,154,000 | 1.41% | ||
| 14 | PERCEPTIVE ADVISORS LLC | 306,715 | 10,916,000 | 1.38% | ||
| 15 | PFM Health Sciences, LP | 273,965 | 9,750,000 | 1.23% | ||
| 16 | JPMORGAN CHASE & CO | 270,446 | 9,625,000 | 1.22% | ||
| 17 | Asset Management One Co., Ltd. | 279,342 | 9,603,000 | 1.21% | ||
| 18 | HAYMAN CAPITAL MANAGEMENT, L.P. | 265,376 | 9,445,000 | 1.19% | ||
| 19 | EVENTIDE ASSET MANAGEMENT, LLC | 241,500 | 8,595,000 | 1.09% | ||
| 20 | CADIAN CAPITAL MANAGEMENT, LP | 225,000 | 8,008,000 | 1.01% | ||
| 21 | MORGAN STANLEY | 157,214 | 5,595,000 | 0.71% | ||
| 22 | MILLENNIUM MANAGEMENT LLC | 123,256 | 4,387,000 | 0.55% | ||
| 23 | Tekla Capital Management LLC | 65,600 | 2,335,000 | 0.29% | ||
| 24 | ArrowMark Colorado Holdings LLC | 61,148 | 2,176,000 | 0.27% | ||
| 25 | Point72 Asset Management, L.P. | 55,700 | 1,982,000 | 0.25% | ||
| 26 | DEUTSCHE BANK AG\ | 55,370 | 1,969,000 | 0.25% | ||
| 27 | Lombard Odier Asset Management (USA) Corp | 53,480 | 1,903,000 | 0.24% | ||
| 28 | NORGES BANK | 50,000 | 1,780,000 | 0.22% | ||
| 29 | A.R.T. Advisors, LLC | 38,360 | 1,365,000 | 0.17% | ||
| 30 | GAM Holding AG | 35,700 | 1,271,000 | 0.16% | ||
| 31 | D. E. Shaw & Co., Inc. | 34,576 | 1,231,000 | 0.16% | ||
| 32 | DRIEHAUS CAPITAL MANAGEMENT LLC | 34,026 | 1,211,000 | 0.15% | ||
| 33 | Atika Capital Management LLC | 28,000 | 996,000 | 0.13% | ||
| 34 | Trexquant Investment LP | 26,600 | 946,000 | 0.12% | ||
| 35 | Rock Springs Capital Management LP | 25,000 | 890,000 | 0.11% | ||
| 36 | OLD MISSION CAPITAL LLC | 20,553 | 731,000 | 0.09% | ||
| 37 | CITADEL ADVISORS LLC | 20,086 | 715,000 | 0.09% | ||
| 38 | SABBY MANAGEMENT, LLC | 18,541 | 660,000 | 0.08% | ||
| 39 | FRED ALGER MANAGEMENT, LLC | 16,651 | 593,000 | 0.07% | ||
| 40 | Geduld E E | 8,510 | 303,000 | 0.04% | ||
| 41 | Partner Investment Management, L.P. | 6,195 | 220,000 | 0.03% | ||
| 42 | UBS Group AG | 5,910 | 211,000 | 0.03% | ||
| 43 | Quantbot Technologies LP | 5,330 | 189,000 | 0.02% | ||
| 44 | WELLS FARGO & COMPANY/MN | 2,500 | 89,000 | 0.01% | ||
| 45 | CITIGROUP INC | 1,769 | 63,000 | 0.01% | ||
| 46 | BlackRock Institutional Trust Company, N.A. | 1,600 | 57,000 | 0.01% | ||
| 47 | BlackRock Finance, Inc. | 700 | 25,000 | 0.00% | ||
| 48 | ROYAL BANK OF CANADA | 500 | 18,000 | 0.00% | ||
| 49 | MSI Financial Services Inc | 300 | 11,000 | 0.00% | ||
| 50 | Tower Research Capital LLC (TRC) | 183 | 7,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
