| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 5,462,019 | 198,326,000 | 23.79% | ||
| 2 | FMR LLC | 4,121,456 | 149,650,000 | 17.95% | ||
| 3 | JANUS HENDERSON INVESTORS US LLC | 3,069,966 | 111,465,000 | 13.37% | ||
| 4 | TimesSquare Capital Management, LLC | 998,238 | 36,246,000 | 4.35% | ||
| 5 | ALLIANCEBERNSTEIN L.P. | 861,660 | 30,666,000 | 3.68% | ||
| 6 | Invesco Ltd. | 754,588 | 27,400,000 | 3.29% | ||
| 7 | JENNISON ASSOCIATES LLC | 721,775 | 26,208,000 | 3.14% | ||
| 8 | GILDER GAGNON HOWE & CO LLC | 714,254 | 25,935,000 | 3.11% | ||
| 9 | Visium Asset Management, LP | 511,952 | 18,589,000 | 2.23% | ||
| 10 | RS INVESTMENT MANAGEMENT CO LLC | 502,860 | 18,259,000 | 2.19% | ||
| 11 | OAK RIDGE INVESTMENTS LLC | 482,560 | 17,522,000 | 2.10% | ||
| 12 | Artisan Partners Limited Partnership | 471,923 | 17,136,000 | 2.06% | ||
| 13 | DEERFIELD MANAGEMENT COMPANY, L.P. | 461,869 | 16,770,000 | 2.01% | ||
| 14 | ArrowMark Colorado Holdings LLC | 458,892 | 16,662,000 | 2.00% | ||
| 15 | FIRST MANHATTAN CO. LLC. | 313,422 | 11,380,000 | 1.37% | ||
| 16 | PERCEPTIVE ADVISORS LLC | 306,715 | 11,137,000 | 1.34% | ||
| 17 | BlackRock Fund Advisors | 264,204 | 9,593,000 | 1.15% | ||
| 18 | Asset Management One Co., Ltd. | 263,688 | 9,585,000 | 1.15% | ||
| 19 | EVENTIDE ASSET MANAGEMENT, LLC | 249,600 | 9,063,000 | 1.09% | ||
| 20 | JPMORGAN CHASE & CO | 241,872 | 8,782,000 | 1.05% | ||
| 21 | CADIAN CAPITAL MANAGEMENT, LP | 207,100 | 7,520,000 | 0.90% | ||
| 22 | DEUTSCHE BANK AG\ | 182,299 | 6,619,000 | 0.79% | ||
| 23 | Point72 Asset Management, L.P. | 160,800 | 5,839,000 | 0.70% | ||
| 24 | Ghost Tree Capital, LLC | 80,000 | 5,314,000 | 0.64% | ||
| 25 | MORGAN STANLEY | 102,070 | 3,707,000 | 0.44% | ||
| 26 | MOORE CAPITAL MANAGEMENT, LP | 100,000 | 3,631,000 | 0.44% | ||
| 27 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 85,448 | 3,102,000 | 0.37% | ||
| 28 | NEW YORK STATE COMMON RETIREMENT FUND | 70,243 | 2,551,000 | 0.31% | ||
| 29 | Tekla Capital Management LLC | 65,600 | 2,382,000 | 0.29% | ||
| 30 | ALPS ADVISORS INC | 63,506 | 2,306,000 | 0.28% | ||
| 31 | Lombard Odier Asset Management (USA) Corp | 55,709 | 2,023,000 | 0.24% | ||
| 32 | NORGES BANK | 50,000 | 1,816,000 | 0.22% | ||
| 33 | SABBY MANAGEMENT, LLC | 46,587 | 1,692,000 | 0.20% | ||
| 34 | SEI INVESTMENTS CO | 43,438 | 1,577,000 | 0.19% | ||
| 35 | GW&K Investment Management, LLC | 41,680 | 1,513,000 | 0.18% | ||
| 36 | GAM Holding AG | 35,700 | 1,296,000 | 0.16% | ||
| 37 | DRIEHAUS CAPITAL MANAGEMENT LLC | 32,667 | 1,186,000 | 0.14% | ||
| 38 | MILLENNIUM MANAGEMENT LLC | 31,394 | 1,140,000 | 0.14% | ||
| 39 | FRED ALGER MANAGEMENT, LLC | 29,380 | 1,067,000 | 0.13% | ||
| 40 | Rock Springs Capital Management LP | 25,000 | 908,000 | 0.11% | ||
| 41 | D. E. Shaw & Co., Inc. | 24,047 | 873,000 | 0.10% | ||
| 42 | ProShare Advisors LLC | 18,365 | 667,000 | 0.08% | ||
| 43 | BANK OF AMERICA CORP /DE/ | 18,308 | 665,000 | 0.08% | ||
| 44 | HBK INVESTMENTS L P | 15,224 | 553,000 | 0.07% | ||
| 45 | A.R.T. Advisors, LLC | 13,371 | 485,000 | 0.06% | ||
| 46 | Trexquant Investment LP | 8,800 | 320,000 | 0.04% | ||
| 47 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 8,668 | 315,000 | 0.04% | ||
| 48 | CREDIT SUISSE AG/ | 8,477 | 307,000 | 0.04% | ||
| 49 | Redmile Group, LLC | 7,994 | 290,000 | 0.03% | ||
| 50 | GEODE CAPITAL MANAGEMENT, LLC | 7,973 | 289,000 | 0.03% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
