| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 5,509,560 | 179,336,000 | 23.80% | ||
| 2 | FMR LLC | 4,142,733 | 134,847,000 | 17.89% | ||
| 3 | JANUS HENDERSON INVESTORS US LLC | 2,979,509 | 97,005,000 | 12.87% | ||
| 4 | OAK RIDGE INVESTMENTS LLC | 1,312,813 | 42,732,000 | 5.67% | ||
| 5 | TimesSquare Capital Management, LLC | 989,603 | 32,212,000 | 4.27% | ||
| 6 | DEERFIELD MANAGEMENT COMPANY, L.P. | 817,806 | 26,620,000 | 3.53% | ||
| 7 | Invesco Ltd. | 753,975 | 24,542,000 | 3.26% | ||
| 8 | ArrowMark Colorado Holdings LLC | 751,487 | 24,461,000 | 3.25% | ||
| 9 | GILDER GAGNON HOWE & CO LLC | 661,232 | 21,523,000 | 2.86% | ||
| 10 | ALLIANCEBERNSTEIN L.P. | 660,267 | 21,492,000 | 2.85% | ||
| 11 | Artisan Partners Limited Partnership | 577,209 | 18,788,000 | 2.49% | ||
| 12 | JENNISON ASSOCIATES LLC | 541,010 | 17,610,000 | 2.34% | ||
| 13 | PERCEPTIVE ADVISORS LLC | 416,696 | 13,563,000 | 1.80% | ||
| 14 | Visium Asset Management, LP | 381,422 | 12,415,000 | 1.65% | ||
| 15 | FIRST MANHATTAN CO. LLC. | 313,422 | 10,201,000 | 1.35% | ||
| 16 | BlackRock Fund Advisors | 307,467 | 10,008,000 | 1.33% | ||
| 17 | Asset Management One Co., Ltd. | 273,266 | 8,629,000 | 1.14% | ||
| 18 | EVENTIDE ASSET MANAGEMENT, LLC | 249,600 | 8,124,000 | 1.08% | ||
| 19 | JPMORGAN CHASE & CO | 238,643 | 7,767,000 | 1.03% | ||
| 20 | Point72 Asset Management, L.P. | 208,200 | 6,777,000 | 0.90% | ||
| 21 | GW&K Investment Management, LLC | 109,838 | 3,575,000 | 0.47% | ||
| 22 | CADIAN CAPITAL MANAGEMENT, LP | 93,190 | 3,033,000 | 0.40% | ||
| 23 | NEW YORK STATE COMMON RETIREMENT FUND | 87,362 | 2,844,000 | 0.38% | ||
| 24 | Ghost Tree Capital, LLC | 45,000 | 2,583,000 | 0.34% | ||
| 25 | Rock Springs Capital Management LP | 73,000 | 2,376,000 | 0.32% | ||
| 26 | JANE STREET GROUP, LLC | 71,499 | 2,335,000 | 0.31% | ||
| 27 | SABBY MANAGEMENT, LLC | 70,000 | 2,279,000 | 0.30% | ||
| 28 | Tekla Capital Management LLC | 65,600 | 2,135,000 | 0.28% | ||
| 29 | ALPS ADVISORS INC | 54,215 | 1,765,000 | 0.23% | ||
| 30 | MILLENNIUM MANAGEMENT LLC | 52,639 | 1,713,000 | 0.23% | ||
| 31 | NORGES BANK | 50,000 | 1,628,000 | 0.22% | ||
| 32 | SEI INVESTMENTS CO | 44,038 | 1,433,000 | 0.19% | ||
| 33 | MORGAN STANLEY | 36,113 | 1,175,000 | 0.16% | ||
| 34 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 31,918 | 1,039,000 | 0.14% | ||
| 35 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 20,500 | 667,000 | 0.09% | ||
| 36 | ProShare Advisors LLC | 17,426 | 567,000 | 0.08% | ||
| 37 | HBK INVESTMENTS L P | 15,224 | 496,000 | 0.07% | ||
| 38 | FRED ALGER MANAGEMENT, LLC | 12,570 | 409,000 | 0.05% | ||
| 39 | BARCLAYS PLC | 12,487 | 400,000 | 0.05% | ||
| 40 | DEUTSCHE BANK AG\ | 10,639 | 345,000 | 0.05% | ||
| 41 | CREDIT SUISSE AG/ | 10,331 | 336,000 | 0.04% | ||
| 42 | FIRST NEW YORK SECURITIES LLC /NY | 10,000 | 325,500 | 0.04% | ||
| 43 | DekaBank Deutsche Girozentrale | 9,900 | 313,000 | 0.04% | ||
| 44 | GEODE CAPITAL MANAGEMENT, LLC | 9,237 | 300,000 | 0.04% | ||
| 45 | A.R.T. Advisors, LLC | 7,371 | 239,000 | 0.03% | ||
| 46 | BANK OF AMERICA CORP /DE/ | 5,711 | 186,000 | 0.02% | ||
| 47 | CASTLEARK MANAGEMENT LLC | 4,100 | 133,000 | 0.02% | ||
| 48 | CITIGROUP INC | 3,028 | 99,000 | 0.01% | ||
| 49 | WELLS FARGO & COMPANY/MN | 2,500 | 81,000 | 0.01% | ||
| 50 | ROYAL BANK OF CANADA | 1,900 | 62,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
