| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 5,509,560 | 179,722,000 | 23.70% | ||
| 2 | FMR LLC | 4,195,397 | 136,854,000 | 18.05% | ||
| 3 | JANUS HENDERSON INVESTORS US LLC | 2,917,723 | 95,169,000 | 12.55% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,743,229 | 56,864,000 | 7.50% | ||
| 5 | OAK RIDGE INVESTMENTS LLC | 1,284,400 | 41,897,000 | 5.52% | ||
| 6 | TimesSquare Capital Management, LLC | 984,553 | 32,116,000 | 4.23% | ||
| 7 | ALLIANCEBERNSTEIN L.P. | 794,220 | 25,907,000 | 3.42% | ||
| 8 | Invesco Ltd. | 677,220 | 22,091,000 | 2.91% | ||
| 9 | ArrowMark Colorado Holdings LLC | 676,342 | 22,062,000 | 2.91% | ||
| 10 | Artisan Partners Limited Partnership | 556,614 | 18,157,000 | 2.39% | ||
| 11 | PERCEPTIVE ADVISORS LLC | 546,696 | 17,833,000 | 2.35% | ||
| 12 | JENNISON ASSOCIATES LLC | 534,589 | 17,438,000 | 2.30% | ||
| 13 | FIRST MANHATTAN CO. LLC. | 313,422 | 10,223,000 | 1.35% | ||
| 14 | BlackRock Fund Advisors | 300,477 | 9,802,000 | 1.29% | ||
| 15 | Asset Management One Co., Ltd. | 259,444 | 8,408,000 | 1.11% | ||
| 16 | JPMORGAN CHASE & CO | 254,492 | 8,301,000 | 1.09% | ||
| 17 | EVENTIDE ASSET MANAGEMENT, LLC | 249,600 | 8,142,000 | 1.07% | ||
| 18 | Point72 Asset Management, L.P. | 202,400 | 6,602,000 | 0.87% | ||
| 19 | EXANE ASSET MANAGEMENT | 135,090 | 4,406,636 | 0.58% | ||
| 20 | GW&K Investment Management, LLC | 124,872 | 4,073,000 | 0.54% | ||
| 21 | MORGAN STANLEY | 118,665 | 3,871,000 | 0.51% | ||
| 22 | CADIAN CAPITAL MANAGEMENT, LP | 93,190 | 3,040,000 | 0.40% | ||
| 23 | NEW YORK STATE COMMON RETIREMENT FUND | 87,362 | 2,850,000 | 0.38% | ||
| 24 | Rock Springs Capital Management LP | 73,000 | 2,381,000 | 0.31% | ||
| 25 | MILLENNIUM MANAGEMENT LLC | 72,298 | 2,358,000 | 0.31% | ||
| 26 | ALPS ADVISORS INC | 67,723 | 2,209,000 | 0.29% | ||
| 27 | Tekla Capital Management LLC | 65,600 | 2,140,000 | 0.28% | ||
| 28 | DEUTSCHE BANK AG\ | 64,354 | 2,098,000 | 0.28% | ||
| 29 | SPHERA FUNDS MANAGEMENT LTD. | 60,611 | 1,977,000 | 0.26% | ||
| 30 | NORGES BANK | 50,000 | 1,631,000 | 0.22% | ||
| 31 | SEI INVESTMENTS CO | 44,038 | 1,437,000 | 0.19% | ||
| 32 | GOLDMAN SACHS GROUP INC | 27,917 | 911,000 | 0.12% | ||
| 33 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 25,000 | 816,000 | 0.11% | ||
| 34 | ProShare Advisors LLC | 17,433 | 569,000 | 0.08% | ||
| 35 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 15,818 | 516,000 | 0.07% | ||
| 36 | HBK INVESTMENTS L P | 15,224 | 497,000 | 0.07% | ||
| 37 | FRED ALGER MANAGEMENT, LLC | 12,150 | 396,000 | 0.05% | ||
| 38 | DekaBank Deutsche Girozentrale | 11,100 | 360,000 | 0.05% | ||
| 39 | CREDIT SUISSE AG/ | 10,159 | 332,000 | 0.04% | ||
| 40 | GEODE CAPITAL MANAGEMENT, LLC | 9,829 | 320,000 | 0.04% | ||
| 41 | BANK OF AMERICA CORP /DE/ | 9,659 | 315,000 | 0.04% | ||
| 42 | BlackRock Institutional Trust Company, N.A. | 7,112 | 232,000 | 0.03% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 6,400 | 209,000 | 0.03% | Put | |
| 44 | CASTLEARK MANAGEMENT LLC | 5,490 | 179,000 | 0.02% | ||
| 45 | ROYAL BANK OF CANADA | 4,100 | 133,000 | 0.02% | ||
| 46 | GILDER GAGNON HOWE & CO LLC | 2,990 | 98,000 | 0.01% | ||
| 47 | Cubist Systematic Strategies, LLC | 2,859 | 93,000 | 0.01% | ||
| 48 | CITIGROUP INC | 2,794 | 91,000 | 0.01% | ||
| 49 | Compagnie Lombard Odier SCmA | 1,200 | 39,000 | 0.01% | ||
| 50 | BESSEMER GROUP INC | 1,131 | 37,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
