| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 5,509,560 | 200,162,000 | 23.23% | ||
| 2 | FMR LLC | 4,254,215 | 154,555,000 | 17.93% | ||
| 3 | JANUS HENDERSON INVESTORS US LLC | 2,758,929 | 100,233,000 | 11.63% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,743,229 | 63,332,000 | 7.35% | ||
| 5 | OAK RIDGE INVESTMENTS LLC | 1,271,910 | 46,208,000 | 5.36% | ||
| 6 | TimesSquare Capital Management, LLC | 990,503 | 35,985,000 | 4.18% | ||
| 7 | ALLIANCEBERNSTEIN L.P. | 771,609 | 28,033,000 | 3.25% | ||
| 8 | ArrowMark Colorado Holdings LLC | 739,735 | 26,875,000 | 3.12% | ||
| 9 | PERCEPTIVE ADVISORS LLC | 563,268 | 20,464,000 | 2.37% | ||
| 10 | Artisan Partners Limited Partnership | 549,345 | 19,958,000 | 2.32% | ||
| 11 | Invesco Ltd. | 534,732 | 19,426,000 | 2.25% | ||
| 12 | JENNISON ASSOCIATES LLC | 533,058 | 19,366,000 | 2.25% | ||
| 13 | ORBIMED ADVISORS LLC | 345,700 | 12,559,000 | 1.46% | ||
| 14 | FIRST MANHATTAN CO. LLC. | 313,422 | 11,386,000 | 1.32% | ||
| 15 | BlackRock Fund Advisors | 311,096 | 11,302,000 | 1.31% | ||
| 16 | Ghost Tree Capital, LLC | 250,000 | 9,083,000 | 1.05% | ||
| 17 | EVENTIDE ASSET MANAGEMENT, LLC | 249,600 | 9,068,000 | 1.05% | ||
| 18 | Asset Management One Co., Ltd. | 234,686 | 8,486,000 | 0.98% | ||
| 19 | PRICE T ROWE ASSOCIATES INC /MD/ | 168,300 | 6,114,000 | 0.71% | ||
| 20 | Point72 Asset Management, L.P. | 166,543 | 6,051,000 | 0.70% | ||
| 21 | GREAT POINT PARTNERS LLC | 131,452 | 4,776,000 | 0.55% | ||
| 22 | EXANE ASSET MANAGEMENT | 126,307 | 4,588,733 | 0.53% | ||
| 23 | GW&K Investment Management, LLC | 120,888 | 4,392,000 | 0.51% | ||
| 24 | MORGAN STANLEY | 100,358 | 3,647,000 | 0.42% | ||
| 25 | CADIAN CAPITAL MANAGEMENT, LP | 93,190 | 3,386,000 | 0.39% | ||
| 26 | NEW YORK STATE COMMON RETIREMENT FUND | 87,362 | 3,174,000 | 0.37% | ||
| 27 | SPHERA FUNDS MANAGEMENT LTD. | 79,058 | 2,872,000 | 0.33% | ||
| 28 | Rock Springs Capital Management LP | 73,000 | 2,652,000 | 0.31% | ||
| 29 | DEUTSCHE BANK AG\ | 72,474 | 2,632,000 | 0.31% | ||
| 30 | JPMORGAN CHASE & CO | 69,602 | 2,528,000 | 0.29% | ||
| 31 | Tekla Capital Management LLC | 65,600 | 2,383,000 | 0.28% | ||
| 32 | ALPS ADVISORS INC | 61,457 | 2,233,000 | 0.26% | ||
| 33 | ACUTA CAPITAL PARTNERS, LLC | 56,260 | 2,044,000 | 0.24% | ||
| 34 | NORGES BANK | 50,000 | 1,735,000 | 0.20% | ||
| 35 | SEI INVESTMENTS CO | 44,038 | 1,600,000 | 0.19% | ||
| 36 | SECTORAL ASSET MANAGEMENT INC | 39,301 | 1,428,000 | 0.17% | ||
| 37 | GOLDMAN SACHS GROUP INC | 33,570 | 1,220,000 | 0.14% | ||
| 38 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 18,500 | 672,000 | 0.08% | ||
| 39 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 15,902 | 578,000 | 0.07% | ||
| 40 | HBK INVESTMENTS L P | 15,224 | 553,000 | 0.06% | ||
| 41 | ProShare Advisors LLC | 14,898 | 541,000 | 0.06% | ||
| 42 | MILLENNIUM MANAGEMENT LLC | 13,604 | 494,000 | 0.06% | ||
| 43 | FRED ALGER MANAGEMENT, LLC | 12,150 | 441,000 | 0.05% | ||
| 44 | GEODE CAPITAL MANAGEMENT, LLC | 9,888 | 359,000 | 0.04% | ||
| 45 | CREDIT SUISSE AG/ | 9,257 | 336,000 | 0.04% | ||
| 46 | BANK OF AMERICA CORP /DE/ | 8,625 | 314,000 | 0.04% | ||
| 47 | TD ASSET MANAGEMENT INC | 7,500 | 272,000 | 0.03% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 5,700 | 207,000 | 0.02% | Call | |
| 49 | Commonwealth Equity Services, Inc | 5,500 | 200,000 | 0.02% | ||
| 50 | CASTLEARK MANAGEMENT LLC | 4,090 | 149,000 | 0.02% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
