| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,040,704 | 90,552,000 | 23.09% | ||
| 2 | JANUS HENDERSON INVESTORS US LLC | 2,564,428 | 76,369,000 | 19.48% | ||
| 3 | BAKER BROS. ADVISORS LP | 1,862,019 | 55,451,000 | 14.14% | ||
| 4 | ALLIANCEBERNSTEIN L.P. | 797,250 | 23,742,000 | 6.06% | ||
| 5 | Invesco Ltd. | 770,629 | 22,949,000 | 5.85% | ||
| 6 | JENNISON ASSOCIATES LLC | 629,624 | 18,750,000 | 4.78% | ||
| 7 | TimesSquare Capital Management, LLC | 605,200 | 18,023,000 | 4.60% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 592,201 | 17,636,000 | 4.50% | ||
| 9 | Visium Asset Management, LP | 444,405 | 13,234,000 | 3.38% | ||
| 10 | Point72 Asset Management, L.P. | 400,000 | 11,912,000 | 3.04% | ||
| 11 | DEUTSCHE BANK AG\ | 325,366 | 9,689,000 | 2.47% | ||
| 12 | Asset Management One Co., Ltd. | 285,443 | 8,320,000 | 2.12% | ||
| 13 | JPMORGAN CHASE & CO | 224,202 | 6,676,000 | 1.70% | ||
| 14 | DEERFIELD MANAGEMENT COMPANY, L.P. | 160,259 | 4,773,000 | 1.22% | ||
| 15 | EVENTIDE ASSET MANAGEMENT, LLC | 128,400 | 3,824,000 | 0.98% | ||
| 16 | Iguana Healthcare Management, LLC | 90,000 | 2,680,000 | 0.68% | ||
| 17 | MORGAN STANLEY | 79,537 | 2,369,000 | 0.60% | ||
| 18 | CADIAN CAPITAL MANAGEMENT, LP | 50,000 | 1,489,000 | 0.38% | ||
| 19 | GAM Holding AG | 35,700 | 1,063,000 | 0.27% | ||
| 20 | A.R.T. Advisors, LLC | 24,582 | 732,000 | 0.19% | ||
| 21 | D. E. Shaw & Co., Inc. | 22,583 | 673,000 | 0.17% | ||
| 22 | BARCLAYS PLC | 18,200 | 527,000 | 0.13% | ||
| 23 | FIRST MANHATTAN CO. LLC. | 13,422 | 399,000 | 0.10% | ||
| 24 | PERCEPTIVE ADVISORS LLC | 3,002 | 89,000 | 0.02% | ||
| 25 | WELLS FARGO & COMPANY/MN | 1,500 | 45,000 | 0.01% | ||
| 26 | UBS Group AG | 1,052 | 31,000 | 0.01% | ||
| 27 | CITIGROUP INC | 1,000 | 30,000 | 0.01% | ||
| 28 | PRELUDE CAPITAL MANAGEMENT, LLC | 1,000 | 30,000 | 0.01% | ||
| 29 | ROYAL BANK OF CANADA | 1,000 | 30,000 | 0.01% | ||
| 30 | MSI Financial Services Inc | 500 | 15,000 | 0.00% | ||
| 31 | TCI Wealth Advisors, Inc. | 20 | 1,000 | 0.00% | ||
| 32 | Tower Research Capital LLC (TRC) | 20 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
