| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,507,761 | 96,463,000 | 54.60% | ||
| 2 | Cormorant Asset Management, LP | 469,145 | 12,901,000 | 7.30% | ||
| 3 | ORBIMED ADVISORS LLC | 350,000 | 9,625,000 | 5.45% | ||
| 4 | Tekla Capital Management LLC | 310,250 | 8,532,000 | 4.83% | ||
| 5 | LAZARD ASSET MANAGEMENT LLC | 259,063 | 7,124,000 | 4.03% | ||
| 6 | FRANKLIN RESOURCES INC | 243,700 | 6,702,000 | 3.79% | ||
| 7 | Artal Group S.A. | 210,000 | 5,775,000 | 3.27% | ||
| 8 | TAUBE HODSON STONEX PARTNERS LLP | 170,112 | 4,678,000 | 2.65% | ||
| 9 | CLOUGH CAPITAL PARTNERS L P | 160,950 | 4,426,000 | 2.51% | ||
| 10 | Abingworth LLP | 100,000 | 2,735,000 | 1.55% | ||
| 11 | UBS Group AG | 92,548 | 2,545,000 | 1.44% | ||
| 12 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 71,500 | 1,966,000 | 1.11% | ||
| 13 | Hudson Bay Capital Management LP | 55,635 | 1,530,000 | 0.87% | ||
| 14 | CITADEL ADVISORS LLC | 51,445 | 1,415,000 | 0.80% | ||
| 15 | BAKER BROS. ADVISORS LP | 50,000 | 1,375,000 | 0.78% | ||
| 16 | PUTNAM INVESTMENTS LLC | 40,000 | 1,100,000 | 0.62% | ||
| 17 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 28,600 | 787,000 | 0.45% | ||
| 18 | MILLENNIUM MANAGEMENT LLC | 27,654 | 760,000 | 0.43% | ||
| 19 | PICTON MAHONEY ASSET MANAGEMENT | 26,800 | 737,000 | 0.42% | SH | |
| 20 | Avoro Capital Advisors LLC | 25,000 | 688,000 | 0.39% | ||
| 21 | Nicholas Investment Partners, LP | 18,662 | 513,000 | 0.29% | ||
| 22 | A.R.T. Advisors, LLC | 17,965 | 494,000 | 0.28% | ||
| 23 | BANK OF AMERICA CORP /DE/ | 14,687 | 404,000 | 0.23% | ||
| 24 | HighTower Advisors, LLC | 13,400 | 369,000 | 0.21% | ||
| 25 | DEUTSCHE BANK AG\ | 13,163 | 361,000 | 0.20% | ||
| 26 | Trexquant Investment LP | 12,628 | 347,000 | 0.20% | ||
| 27 | OPPENHEIMER & CO INC | 12,335 | 339,000 | 0.19% | ||
| 28 | DELTEC ASSET MANAGEMENT LLC | 12,000 | 330,000 | 0.19% | ||
| 29 | Creative Planning | 9,850 | 271,000 | 0.15% | ||
| 30 | GAM Holding AG | 9,410 | 259,000 | 0.15% | ||
| 31 | Apex Capital Management | 9,229 | 254,000 | 0.14% | ||
| 32 | Bank of New York Mellon Corp | 8,130 | 224,000 | 0.13% | ||
| 33 | Raymond James Financial Services Advisors, Inc. | 7,375 | 203,000 | 0.11% | ||
| 34 | MORGAN STANLEY | 4,438 | 122,000 | 0.07% | ||
| 35 | PERCEPTIVE ADVISORS LLC | 2,996 | 82,000 | 0.05% | ||
| 36 | FIRST NEW YORK SECURITIES LLC /NY | 2,341 | 64,378 | 0.04% | ||
| 37 | NEW YORK STATE COMMON RETIREMENT FUND | 1,973 | 54,000 | 0.03% | ||
| 38 | Vident Investment Advisory, LLC | 1,371,426 | 50,000 | 0.03% | ||
| 39 | ROYAL BANK OF CANADA | 1,270 | 35,000 | 0.02% | ||
| 40 | WELLS FARGO & COMPANY/MN | 400 | 11,000 | 0.01% | ||
| 41 | D.A. DAVIDSON & CO. | 300 | 8,000 | 0.00% | ||
| 42 | ADVANTAGE INVESTMENT MANAGEMENT, LLC | 200 | 6,000 | 0.00% | ||
| 43 | GENEOS WEALTH MANAGEMENT INC. | 247 | 6,000 | 0.00% | ||
| 44 | CITIGROUP INC | 37 | 1,000 | 0.00% | ||
| 45 | Tower Research Capital LLC (TRC) | 15 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
