| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,502,695 | 92,331,000 | 50.93% | ||
| 2 | ORBIMED ADVISORS LLC | 350,000 | 9,226,000 | 5.09% | ||
| 3 | BLACKROCK ADVISORS LLC | 343,309 | 9,050,000 | 4.99% | ||
| 4 | JPMORGAN CHASE & CO | 300,000 | 7,908,000 | 4.36% | ||
| 5 | FRANKLIN RESOURCES INC | 243,700 | 6,424,000 | 3.54% | ||
| 6 | PERCEPTIVE ADVISORS LLC | 218,679 | 5,764,000 | 3.18% | ||
| 7 | PICTON MAHONEY ASSET MANAGEMENT | 202,300 | 5,333,000 | 2.94% | SH | |
| 8 | LAZARD ASSET MANAGEMENT LLC | 193,395 | 5,097,000 | 2.81% | ||
| 9 | GLG LLC | 183,959 | 4,849,000 | 2.67% | ||
| 10 | Tekla Capital Management LLC | 158,382 | 4,175,000 | 2.30% | ||
| 11 | Hudson Bay Capital Management LP | 157,718 | 4,157,000 | 2.29% | ||
| 12 | Artal Group S.A. | 125,000 | 3,295,000 | 1.82% | ||
| 13 | UBS Group AG | 113,751 | 2,999,000 | 1.65% | ||
| 14 | BlackRock Group LTD | 98,200 | 2,589,000 | 1.43% | ||
| 15 | CITADEL ADVISORS LLC | 91,816 | 2,421,000 | 1.34% | ||
| 16 | Ghost Tree Capital, LLC | 75,000 | 1,977,000 | 1.09% | ||
| 17 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 67,700 | 1,785,000 | 0.98% | ||
| 18 | BAKER BROS. ADVISORS LP | 50,000 | 1,318,000 | 0.73% | ||
| 19 | Virtu KCG Holdings LLC | 40,674 | 1,072,000 | 0.59% | ||
| 20 | PUTNAM INVESTMENTS LLC | 40,000 | 1,054,000 | 0.58% | ||
| 21 | JANE STREET GROUP, LLC | 36,219 | 968,000 | 0.53% | ||
| 22 | Avoro Capital Advisors LLC | 35,000 | 923,000 | 0.51% | ||
| 23 | Point72 Asset Management, L.P. | 35,000 | 923,000 | 0.51% | ||
| 24 | BlackRock Finance, Inc. | 29,400 | 775,000 | 0.43% | ||
| 25 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 24,100 | 635,000 | 0.35% | ||
| 26 | ArrowMark Colorado Holdings LLC | 20,525 | 541,000 | 0.30% | ||
| 27 | WALL STREET ASSOCIATES | 20,000 | 527,000 | 0.29% | ||
| 28 | OLD MISSION CAPITAL LLC | 17,980 | 474,000 | 0.26% | ||
| 29 | MILLENNIUM MANAGEMENT LLC | 15,639 | 412,000 | 0.23% | ||
| 30 | DEUTSCHE BANK AG\ | 13,163 | 346,000 | 0.19% | ||
| 31 | A.R.T. Advisors, LLC | 12,765 | 336,000 | 0.19% | ||
| 32 | OPPENHEIMER & CO INC | 12,717 | 335,000 | 0.18% | ||
| 33 | Cormorant Asset Management, LP | 11,300 | 298,000 | 0.16% | ||
| 34 | BlackRock Investment Management, LLC | 10,200 | 269,000 | 0.15% | ||
| 35 | Quinn Opportunity Partners LLC | 9,400 | 248,000 | 0.14% | ||
| 36 | CREDIT SUISSE AG/ | 8,170 | 215,000 | 0.12% | ||
| 37 | MORGAN STANLEY | 4,728 | 124,000 | 0.07% | ||
| 38 | Creative Planning | 2,100 | 55,000 | 0.03% | ||
| 39 | PRELUDE CAPITAL MANAGEMENT, LLC | 1,000 | 26,000 | 0.01% | ||
| 40 | BANK OF AMERICA CORP /DE/ | 1,000 | 26,000 | 0.01% | ||
| 41 | Tower Research Capital LLC (TRC) | 669 | 18,000 | 0.01% | ||
| 42 | CITIGROUP INC | 159 | 4,000 | 0.00% | ||
| 43 | ROYAL BANK OF CANADA | 100 | 3,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
