| 1 |
FMR LLC |
3,454,978 |
119,508,000 |
56.42% |
|
|
| 2 |
JPMORGAN CHASE & CO |
300,746 |
10,400,000 |
4.91% |
|
|
| 3 |
PRICE T ROWE ASSOCIATES INC /MD/ |
300,000 |
10,377,000 |
4.90% |
|
|
| 4 |
ORBIMED ADVISORS LLC |
300,000 |
10,374,000 |
4.90% |
|
|
| 5 |
FRANKLIN RESOURCES INC |
245,000 |
8,475,000 |
4.00% |
|
|
| 6 |
LAZARD ASSET MANAGEMENT LLC |
222,134 |
7,683,000 |
3.63% |
|
|
| 7 |
BLACKROCK ADVISORS LLC |
162,500 |
5,619,000 |
2.65% |
|
|
| 8 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
150,506 |
5,204,000 |
2.46% |
|
|
| 9 |
Artal Group S.A. |
100,000 |
3,458,000 |
1.63% |
|
|
| 10 |
BlackRock Group LTD |
96,100 |
3,323,000 |
1.57% |
|
|
| 11 |
CITADEL ADVISORS LLC |
95,156 |
3,291,000 |
1.55% |
|
|
| 12 |
Rock Springs Capital Management LP |
75,000 |
2,594,000 |
1.22% |
|
|
| 13 |
Point72 Asset Management, L.P. |
65,000 |
2,248,000 |
1.06% |
|
|
| 14 |
WELLINGTON MANAGEMENT GROUP LLP |
54,490 |
1,885,000 |
0.89% |
|
|
| 15 |
BAKER BROS. ADVISORS LP |
50,000 |
1,729,000 |
0.82% |
|
|
| 16 |
SPHERA FUNDS MANAGEMENT LTD. |
50,000 |
1,729,000 |
0.82% |
|
|
| 17 |
PUTNAM INVESTMENTS LLC |
40,000 |
1,384,000 |
0.65% |
|
|
| 18 |
Tekla Capital Management LLC |
40,000 |
1,384,000 |
0.65% |
|
|
| 19 |
MILLENNIUM MANAGEMENT LLC |
33,195 |
1,148,000 |
0.54% |
|
|
| 20 |
BlackRock Finance, Inc. |
31,200 |
1,079,000 |
0.51% |
|
|
| 21 |
Avoro Capital Advisors LLC |
30,000 |
1,037,000 |
0.49% |
|
|
| 22 |
Weiss Multi-Strategy Advisers LLC |
26,300 |
909,000 |
0.43% |
|
|
| 23 |
Cormorant Asset Management, LP |
25,000 |
865,000 |
0.41% |
|
|
| 24 |
SABBY MANAGEMENT, LLC |
22,700 |
785,000 |
0.37% |
|
|
| 25 |
CQS Cayman LP |
20,000 |
692,000 |
0.33% |
|
|
| 26 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
20,000 |
692,000 |
0.33% |
|
|
| 27 |
WALL STREET ASSOCIATES |
20,000 |
692,000 |
0.33% |
|
|
| 28 |
ArrowMark Colorado Holdings LLC |
20,000 |
692,000 |
0.33% |
|
|
| 29 |
HIGHBRIDGE CAPITAL MANAGEMENT LLC |
13,905 |
481,000 |
0.23% |
|
|
| 30 |
LANDSCAPE CAPITAL MANAGEMENT, L.L.C. |
11,148 |
385,000 |
0.18% |
|
|
| 31 |
BlackRock Investment Management, LLC |
10,200 |
353,000 |
0.17% |
|
|
| 32 |
Virtu KCG Holdings LLC |
9,889 |
342,000 |
0.16% |
|
|
| 33 |
TD ASSET MANAGEMENT INC |
9,700 |
336,000 |
0.16% |
|
|
| 34 |
CREDIT AGRICOLE S A |
5,000 |
173,000 |
0.08% |
|
|
| 35 |
BANK OF AMERICA CORP /DE/ |
5,000 |
173,000 |
0.08% |
|
|
| 36 |
PICTON MAHONEY ASSET MANAGEMENT |
5,000 |
173,000 |
0.08% |
|
SH |
| 37 |
PERCEPTIVE ADVISORS LLC |
1,500 |
52,000 |
0.02% |
|
|
| 38 |
PRELUDE CAPITAL MANAGEMENT, LLC |
1,000 |
35,000 |
0.02% |
|
|
| 39 |
Cubist Systematic Strategies, LLC |
600 |
21,000 |
0.01% |
|
|
| 40 |
DEUTSCHE BANK AG\ |
500 |
17,000 |
0.01% |
|
|
| 41 |
MORGAN STANLEY |
506 |
17,000 |
0.01% |
|
|
| 42 |
Tower Research Capital LLC (TRC) |
376 |
13,000 |
0.01% |
|
|
| 43 |
BARCLAYS PLC |
90 |
3,000 |
0.00% |
|
|
| 44 |
CITIGROUP INC |
50 |
2,000 |
0.00% |
|
|
