| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,530,406 | 59,840,000 | 61.90% | ||
| 2 | ORBIMED ADVISORS LLC | 350,000 | 5,933,000 | 6.14% | ||
| 3 | Tekla Capital Management LLC | 310,250 | 5,259,000 | 5.44% | ||
| 4 | LAZARD ASSET MANAGEMENT LLC | 300,754 | 5,097,000 | 5.27% | ||
| 5 | FRANKLIN RESOURCES INC | 243,700 | 4,131,000 | 4.27% | ||
| 6 | Artal Group S.A. | 150,000 | 2,543,000 | 2.63% | ||
| 7 | Abingworth LLP | 100,000 | 1,691,000 | 1.75% | ||
| 8 | Avoro Capital Advisors LLC | 97,096 | 1,646,000 | 1.70% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 70,703 | 1,198,000 | 1.24% | ||
| 10 | MORGAN STANLEY | 70,057 | 1,188,000 | 1.23% | ||
| 11 | DSC Advisors, L.P. | 57,500 | 975,000 | 1.01% | ||
| 12 | Hudson Bay Capital Management LP | 55,635 | 943,000 | 0.98% | ||
| 13 | GAM Holding AG | 53,020 | 899,000 | 0.93% | ||
| 14 | BAKER BROS. ADVISORS LP | 50,000 | 848,000 | 0.88% | ||
| 15 | UBS Group AG | 46,138 | 782,000 | 0.81% | ||
| 16 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 45,100 | 764,000 | 0.79% | Put | |
| 17 | Vident Investment Advisory, LLC | 42,498 | 720,000 | 0.74% | ||
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 15,195 | 258,000 | 0.27% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 14,707 | 249,000 | 0.26% | ||
| 20 | PICTON MAHONEY ASSET MANAGEMENT | 14,600 | 247,000 | 0.26% | SH | |
| 21 | CITADEL ADVISORS LLC | 13,026 | 221,000 | 0.23% | ||
| 22 | ELLINGTON MANAGEMENT GROUP LLC | 12,400 | 210,000 | 0.22% | ||
| 23 | HighTower Advisors, LLC | 12,330 | 210,000 | 0.22% | ||
| 24 | OLD MISSION CAPITAL, LLC | 10,956 | 186,000 | 0.19% | ||
| 25 | BANK OF AMERICA CORP /DE/ | 10,553 | 179,000 | 0.19% | ||
| 26 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 10,010 | 170,000 | 0.18% | ||
| 27 | PRELUDE CAPITAL MANAGEMENT, LLC | 5,000 | 85,000 | 0.09% | ||
| 28 | JPMORGAN CHASE & CO | 4,913 | 83,000 | 0.09% | ||
| 29 | DEUTSCHE BANK AG\ | 3,600 | 61,000 | 0.06% | ||
| 30 | FNY PARTNERS FUND LP | 1,000 | 17,000 | 0.02% | ||
| 31 | BlackRock Finance, Inc. | 900 | 15,000 | 0.02% | ||
| 32 | D.A. DAVIDSON & CO. | 500 | 8,000 | 0.01% | ||
| 33 | NEXT Financial Group, Inc | 400 | 7,000 | 0.01% | ||
| 34 | ADVANTAGE INVESTMENT MANAGEMENT, LLC | 200 | 3,000 | 0.00% | ||
| 35 | ROYAL BANK OF CANADA | 170 | 3,000 | 0.00% | ||
| 36 | CUTLER GROUP LLC / CA | 200 | 2,000 | 0.00% | Put | |
| 37 | TRENT CAPITAL MANAGEMENT INC /NC/ | 105 | 2,000 | 0.00% | ||
| 38 | CUTLER GROUP LLC / CA | 2,800 | 0 | 0.00% | Call | |
| 39 | ENVESTNET ASSET MANAGEMENT INC | 13 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
