| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,530,257 | 85,009,000 | 53.26% | ||
| 2 | Cormorant Asset Management, LP | 498,117 | 11,995,000 | 7.52% | ||
| 3 | ORBIMED ADVISORS LLC | 350,000 | 8,428,000 | 5.28% | ||
| 4 | Tekla Capital Management LLC | 310,250 | 7,471,000 | 4.68% | ||
| 5 | LAZARD ASSET MANAGEMENT LLC | 285,469 | 6,874,000 | 4.31% | ||
| 6 | FRANKLIN RESOURCES INC | 243,700 | 5,868,000 | 3.68% | ||
| 7 | MILLENNIUM MANAGEMENT LLC | 182,035 | 4,383,000 | 2.75% | ||
| 8 | PERCEPTIVE ADVISORS LLC | 179,506 | 4,323,000 | 2.71% | ||
| 9 | CLOUGH CAPITAL PARTNERS L P | 153,350 | 3,693,000 | 2.31% | ||
| 10 | Artal Group S.A. | 150,000 | 3,612,000 | 2.26% | ||
| 11 | Abingworth LLP | 100,000 | 2,407,000 | 1.51% | ||
| 12 | UBS Group AG | 96,904 | 2,333,000 | 1.46% | ||
| 13 | DEUTSCHE BANK AG\ | 70,971 | 1,708,000 | 1.07% | ||
| 14 | MORGAN STANLEY | 64,817 | 1,561,000 | 0.98% | ||
| 15 | Avoro Capital Advisors LLC | 58,671 | 1,413,000 | 0.89% | ||
| 16 | Hudson Bay Capital Management LP | 55,635 | 1,340,000 | 0.84% | ||
| 17 | GAM Holding AG | 54,570 | 1,314,000 | 0.82% | ||
| 18 | BAKER BROS. ADVISORS LP | 50,000 | 1,204,000 | 0.75% | ||
| 19 | PUTNAM INVESTMENTS LLC | 40,000 | 963,000 | 0.60% | ||
| 20 | CITADEL ADVISORS LLC | 30,138 | 726,000 | 0.45% | ||
| 21 | Vident Investment Advisory, LLC | 25,254 | 608,000 | 0.38% | ||
| 22 | BlackRock Institutional Trust Company, N.A. | 17,419 | 419,000 | 0.26% | ||
| 23 | BANK OF AMERICA CORP /DE/ | 16,311 | 393,000 | 0.25% | ||
| 24 | HighTower Advisors, LLC | 13,565 | 327,000 | 0.20% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 11,667 | 281,000 | 0.18% | ||
| 26 | OPPENHEIMER & CO INC | 10,604 | 255,000 | 0.16% | ||
| 27 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 10,010 | 241,000 | 0.15% | ||
| 28 | PICTON MAHONEY ASSET MANAGEMENT | 8,500 | 205,000 | 0.13% | SH | |
| 29 | TLP GROUP LLC | 3,970 | 96,000 | 0.06% | ||
| 30 | PRELUDE CAPITAL MANAGEMENT, LLC | 2,000 | 48,000 | 0.03% | ||
| 31 | ROYAL BANK OF CANADA | 1,170 | 28,000 | 0.02% | ||
| 32 | ADVISOR GROUP, INC. | 741 | 18,000 | 0.01% | ||
| 33 | CUTLER GROUP LLC / CA | 5,200 | 14,000 | 0.01% | Put | |
| 34 | WELLS FARGO & COMPANY/MN | 400 | 10,000 | 0.01% | ||
| 35 | CUTLER GROUP LLC / CA | 6,600 | 8,000 | 0.01% | Call | |
| 36 | D.A. DAVIDSON & CO. | 300 | 7,000 | 0.00% | ||
| 37 | Tower Research Capital LLC (TRC) | 200 | 5,000 | 0.00% | ||
| 38 | ADVANTAGE INVESTMENT MANAGEMENT, LLC | 200 | 5,000 | 0.00% | ||
| 39 | NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 89 | 2,000 | 0.00% | ||
| 40 | CUTLER GROUP LLC / CA | 100 | 2,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
