| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,500,695 | 126,305,000 | 53.03% | ||
| 2 | ORBIMED ADVISORS LLC | 350,000 | 12,628,000 | 5.30% | ||
| 3 | BLACKROCK ADVISORS LLC | 304,626 | 10,990,000 | 4.61% | ||
| 4 | JPMORGAN CHASE & CO | 300,000 | 10,824,000 | 4.54% | ||
| 5 | FRANKLIN RESOURCES INC | 245,000 | 8,840,000 | 3.71% | ||
| 6 | LAZARD ASSET MANAGEMENT LLC | 197,353 | 7,120,000 | 2.99% | ||
| 7 | Hudson Bay Capital Management LP | 192,013 | 6,928,000 | 2.91% | ||
| 8 | PERCEPTIVE ADVISORS LLC | 181,500 | 6,549,000 | 2.75% | ||
| 9 | GLG LLC | 177,635 | 6,409,000 | 2.69% | ||
| 10 | PICTON MAHONEY ASSET MANAGEMENT | 138,600 | 4,999,000 | 2.10% | SH | |
| 11 | Artal Group S.A. | 125,000 | 4,510,000 | 1.89% | ||
| 12 | Ghost Tree Capital, LLC | 125,000 | 4,510,000 | 1.89% | ||
| 13 | BlackRock Group LTD | 98,200 | 3,543,000 | 1.49% | ||
| 14 | CITADEL ADVISORS LLC | 90,582 | 3,268,000 | 1.37% | ||
| 15 | MILLENNIUM MANAGEMENT LLC | 88,214 | 3,183,000 | 1.34% | ||
| 16 | UBS Group AG | 85,280 | 3,077,000 | 1.29% | ||
| 17 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 73,700 | 2,659,000 | 1.12% | ||
| 18 | BAKER BROS. ADVISORS LP | 50,000 | 1,804,000 | 0.76% | ||
| 19 | Tekla Capital Management LLC | 40,000 | 1,443,000 | 0.61% | ||
| 20 | PUTNAM INVESTMENTS LLC | 40,000 | 1,443,000 | 0.61% | ||
| 21 | Avoro Capital Advisors LLC | 30,000 | 1,082,000 | 0.45% | ||
| 22 | BlackRock Finance, Inc. | 29,400 | 1,061,000 | 0.45% | ||
| 23 | ArrowMark Colorado Holdings LLC | 20,525 | 741,000 | 0.31% | ||
| 24 | WALL STREET ASSOCIATES | 20,000 | 722,000 | 0.30% | ||
| 25 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 15,500 | 559,000 | 0.23% | ||
| 26 | DEUTSCHE BANK AG\ | 13,163 | 474,000 | 0.20% | ||
| 27 | MORGAN STANLEY | 11,634 | 419,000 | 0.18% | ||
| 28 | Cormorant Asset Management, LP | 11,300 | 408,000 | 0.17% | ||
| 29 | Quinn Opportunity Partners LLC | 10,400 | 375,000 | 0.16% | ||
| 30 | BlackRock Investment Management, LLC | 10,200 | 368,000 | 0.15% | ||
| 31 | FNY Managed Accounts LLC | 7,400 | 266,992 | 0.11% | ||
| 32 | A.R.T. Advisors, LLC | 7,193 | 259,000 | 0.11% | ||
| 33 | OPPENHEIMER & CO INC | 5,636 | 203,000 | 0.09% | ||
| 34 | PRELUDE CAPITAL MANAGEMENT, LLC | 2,200 | 79,000 | 0.03% | ||
| 35 | Tower Research Capital LLC (TRC) | 1,168 | 42,000 | 0.02% | ||
| 36 | Quantbot Technologies LP | 961 | 34,000 | 0.01% | ||
| 37 | FIRST NEW YORK SECURITIES LLC /NY | 500 | 18,040 | 0.01% | ||
| 38 | WELLS FARGO & COMPANY/MN | 400 | 14,000 | 0.01% | ||
| 39 | BANK OF AMERICA CORP /DE/ | 250 | 9,000 | 0.00% | ||
| 40 | ROYAL BANK OF CANADA | 100 | 4,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
