| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,507,761 | 108,846,000 | 49.75% | ||
| 2 | Cormorant Asset Management, LP | 469,145 | 14,558,000 | 6.65% | ||
| 3 | ORBIMED ADVISORS LLC | 350,000 | 10,861,000 | 4.96% | ||
| 4 | JPMORGAN CHASE & CO | 300,000 | 9,309,000 | 4.25% | ||
| 5 | LAZARD ASSET MANAGEMENT LLC | 262,338 | 8,140,000 | 3.72% | ||
| 6 | FRANKLIN RESOURCES INC | 243,700 | 7,562,000 | 3.46% | ||
| 7 | Artal Group S.A. | 210,000 | 6,516,000 | 2.98% | ||
| 8 | CLOUGH CAPITAL PARTNERS L P | 208,100 | 6,457,000 | 2.95% | ||
| 9 | Tekla Capital Management LLC | 207,250 | 6,431,000 | 2.94% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 187,415 | 5,815,000 | 2.66% | ||
| 11 | Abingworth LLP | 100,000 | 3,100,000 | 1.42% | ||
| 12 | UBS Group AG | 98,798 | 3,066,000 | 1.40% | ||
| 13 | BLACKROCK ADVISORS LLC | 93,586 | 2,904,000 | 1.33% | ||
| 14 | CITADEL ADVISORS LLC | 63,500 | 1,970,000 | 0.90% | ||
| 15 | Hudson Bay Capital Management LP | 63,335 | 1,965,000 | 0.90% | ||
| 16 | GOLDMAN SACHS GROUP INC | 58,162 | 1,805,000 | 0.82% | ||
| 17 | BALYASNY ASSET MANAGEMENT L.P. | 57,162 | 1,774,000 | 0.81% | ||
| 18 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 55,000 | 1,707,000 | 0.78% | ||
| 19 | BAKER BROS. ADVISORS LP | 50,000 | 1,552,000 | 0.71% | ||
| 20 | Opaleye Management Inc. | 50,000 | 1,552,000 | 0.71% | ||
| 21 | A.R.T. Advisors, LLC | 47,365 | 1,469,000 | 0.67% | ||
| 22 | DEUTSCHE BANK AG\ | 42,131 | 1,306,000 | 0.60% | ||
| 23 | PUTNAM INVESTMENTS LLC | 40,000 | 1,241,000 | 0.57% | ||
| 24 | Avoro Capital Advisors LLC | 35,000 | 1,086,000 | 0.50% | ||
| 25 | OLD MISSION CAPITAL LLC | 32,334 | 1,003,000 | 0.46% | ||
| 26 | Vident Investment Advisory, LLC | 26,597 | 825,000 | 0.38% | ||
| 27 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 24,100 | 748,000 | 0.34% | ||
| 28 | Nicholas Investment Partners, LP | 23,752 | 737,000 | 0.34% | ||
| 29 | PICTON MAHONEY ASSET MANAGEMENT | 19,050 | 591,000 | 0.27% | SH | |
| 30 | Trexquant Investment LP | 16,891 | 524,000 | 0.24% | ||
| 31 | HBK INVESTMENTS L P | 15,675 | 486,000 | 0.22% | ||
| 32 | Virtu KCG Holdings LLC | 15,310 | 475,000 | 0.22% | ||
| 33 | OPPENHEIMER & CO INC | 13,797 | 428,000 | 0.20% | ||
| 34 | DELTEC ASSET MANAGEMENT LLC | 12,000 | 372,000 | 0.17% | ||
| 35 | BANK OF AMERICA CORP /DE/ | 11,074 | 343,000 | 0.16% | ||
| 36 | Creative Planning | 9,100 | 282,000 | 0.13% | ||
| 37 | Quinn Opportunity Partners LLC | 8,400 | 261,000 | 0.12% | ||
| 38 | Bank of New York Mellon Corp | 7,996 | 248,000 | 0.11% | ||
| 39 | MORGAN STANLEY | 4,713 | 146,000 | 0.07% | ||
| 40 | PNC FINANCIAL SERVICES GROUP, INC. | 4,000 | 124,000 | 0.06% | ||
| 41 | PERCEPTIVE ADVISORS LLC | 2,996 | 93,000 | 0.04% | ||
| 42 | NEW YORK STATE COMMON RETIREMENT FUND | 1,973 | 61,000 | 0.03% | ||
| 43 | PRELUDE CAPITAL MANAGEMENT, LLC | 1,000 | 31,000 | 0.01% | ||
| 44 | D.A. DAVIDSON & CO. | 300 | 9,000 | 0.00% | ||
| 45 | ADVANTAGE INVESTMENT MANAGEMENT, LLC | 200 | 6,000 | 0.00% | ||
| 46 | ROYAL BANK OF CANADA | 170 | 5,000 | 0.00% | ||
| 47 | Tower Research Capital LLC (TRC) | 100 | 3,000 | 0.00% | ||
| 48 | CITIGROUP INC | 2 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
