| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,529,634 | 93,853,000 | 51.04% | ||
| 2 | Cormorant Asset Management, LP | 498,117 | 13,245,000 | 7.20% | ||
| 3 | ORBIMED ADVISORS LLC | 350,000 | 9,307,000 | 5.06% | ||
| 4 | Tekla Capital Management LLC | 310,250 | 8,250,000 | 4.49% | ||
| 5 | LAZARD ASSET MANAGEMENT LLC | 275,349 | 7,321,000 | 3.98% | ||
| 6 | TAUBE HODSON STONEX PARTNERS LLP | 269,776 | 7,173,000 | 3.90% | ||
| 7 | FRANKLIN RESOURCES INC | 243,700 | 6,480,000 | 3.52% | ||
| 8 | Artal Group S.A. | 210,000 | 5,584,000 | 3.04% | ||
| 9 | PERCEPTIVE ADVISORS LLC | 183,507 | 4,879,000 | 2.65% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 174,893 | 4,650,000 | 2.53% | ||
| 11 | CLOUGH CAPITAL PARTNERS L P | 171,550 | 4,562,000 | 2.48% | ||
| 12 | Abingworth LLP | 100,000 | 2,659,000 | 1.45% | ||
| 13 | UBS Group AG | 97,000 | 2,580,000 | 1.40% | ||
| 14 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 70,333 | 1,870,000 | 1.02% | ||
| 15 | Hudson Bay Capital Management LP | 55,635 | 1,479,000 | 0.80% | ||
| 16 | BAKER BROS. ADVISORS LP | 50,000 | 1,330,000 | 0.72% | ||
| 17 | Avoro Capital Advisors LLC | 42,671 | 1,135,000 | 0.62% | ||
| 18 | PUTNAM INVESTMENTS LLC | 40,000 | 1,064,000 | 0.58% | ||
| 19 | CABOT WEALTH MANAGEMENT INC | 31,686 | 843,000 | 0.46% | ||
| 20 | CITADEL ADVISORS LLC | 30,141 | 801,000 | 0.44% | ||
| 21 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 27,600 | 734,000 | 0.40% | ||
| 22 | DEUTSCHE BANK AG\ | 26,093 | 693,000 | 0.38% | ||
| 23 | Vident Investment Advisory, LLC | 25,254 | 672,000 | 0.37% | ||
| 24 | PICTON MAHONEY ASSET MANAGEMENT | 23,900 | 635,000 | 0.35% | SH | |
| 25 | BANK OF AMERICA CORP /DE/ | 16,053 | 427,000 | 0.23% | ||
| 26 | GAM Holding AG | 15,220 | 405,000 | 0.22% | ||
| 27 | HighTower Advisors, LLC | 13,440 | 357,000 | 0.19% | ||
| 28 | A.R.T. Advisors, LLC | 13,365 | 355,000 | 0.19% | ||
| 29 | OPPENHEIMER & CO INC | 12,101 | 322,000 | 0.18% | ||
| 30 | MORGAN STANLEY | 5,713 | 152,000 | 0.08% | ||
| 31 | ROYAL BANK OF CANADA | 1,170 | 31,000 | 0.02% | ||
| 32 | WELLS FARGO & COMPANY/MN | 400 | 11,000 | 0.01% | ||
| 33 | Tower Research Capital LLC (TRC) | 300 | 8,000 | 0.00% | ||
| 34 | D.A. DAVIDSON & CO. | 300 | 7,000 | 0.00% | ||
| 35 | Creative Planning | 250 | 7,000 | 0.00% | ||
| 36 | GENEOS WEALTH MANAGEMENT INC. | 247 | 6,000 | 0.00% | ||
| 37 | ADVANTAGE INVESTMENT MANAGEMENT, LLC | 200 | 5,000 | 0.00% | ||
| 38 | WOLVERINE TRADING LP /BD | 17 | 453 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
