| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 6,554,967 | 67,057,000 | 31.04% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 4,232,528 | 43,299,000 | 20.04% | ||
| 3 | Camber Capital Management LP | 2,746,622 | 28,098,000 | 13.01% | ||
| 4 | BLACKROCK ADVISORS LLC | 2,473,450 | 25,303,000 | 11.71% | ||
| 5 | BlackRock Group LTD | 936,575 | 9,581,000 | 4.43% | ||
| 6 | Rock Springs Capital Management LP | 752,500 | 7,698,000 | 3.56% | ||
| 7 | Redmile Group, LLC | 660,129 | 6,753,000 | 3.13% | ||
| 8 | VANGUARD GROUP INC | 595,437 | 6,091,000 | 2.82% | ||
| 9 | ORBIMED ADVISORS LLC | 456,666 | 4,672,000 | 2.16% | ||
| 10 | BlackRock Investment Management, LLC | 294,623 | 3,014,000 | 1.40% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 198,772 | 2,033,000 | 0.94% | ||
| 12 | BANK OF AMERICA CORP /DE/ | 197,900 | 2,025,000 | 0.94% | ||
| 13 | BlackRock Fund Advisors | 188,035 | 1,924,000 | 0.89% | ||
| 14 | ROYCE & ASSOCIATES LP | 156,412 | 1,600,000 | 0.74% | ||
| 15 | PERCEPTIVE ADVISORS LLC | 118,366 | 1,211,000 | 0.56% | ||
| 16 | DEUTSCHE BANK AG\ | 91,258 | 933,000 | 0.43% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 82,336 | 842,000 | 0.39% | ||
| 18 | NORTHERN TRUST CORP | 78,963 | 807,000 | 0.37% | ||
| 19 | STATE STREET CORP | 70,176 | 716,000 | 0.33% | ||
| 20 | BlackRock Finance, Inc. | 35,889 | 367,000 | 0.17% | ||
| 21 | Bank of New York Mellon Corp | 33,507 | 343,000 | 0.16% | ||
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 26,421 | 270,000 | 0.12% | ||
| 23 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 22,734 | 233,000 | 0.11% | ||
| 24 | D. E. Shaw & Co., Inc. | 22,136 | 226,000 | 0.10% | ||
| 25 | Hound Partners, LLC | 17,493 | 179,000 | 0.08% | ||
| 26 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 15,546 | 159,000 | 0.07% | ||
| 27 | LPL Financial LLC | 13,000 | 141,000 | 0.07% | ||
| 28 | TEACHERS ADVISORS, LLC | 10,409 | 106,000 | 0.05% | ||
| 29 | CITIGROUP INC | 8,189 | 83,000 | 0.04% | ||
| 30 | NEW YORK STATE COMMON RETIREMENT FUND | 6,700 | 69,000 | 0.03% | ||
| 31 | Nationwide Fund Advisors | 4,832 | 49,000 | 0.02% | ||
| 32 | AMERICAN INTERNATIONAL GROUP, INC. | 4,285 | 44,000 | 0.02% | ||
| 33 | MORGAN STANLEY | 3,403 | 34,000 | 0.02% | ||
| 34 | UBS Group AG | 2,233 | 23,000 | 0.01% | ||
| 35 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 2,338 | 23,000 | 0.01% | ||
| 36 | Tower Research Capital LLC (TRC) | 1,059 | 11,000 | 0.01% | ||
| 37 | WELLS FARGO & COMPANY/MN | 1,005 | 10,000 | 0.00% | ||
| 38 | TRUST CO OF VERMONT | 400 | 4,000 | 0.00% | ||
| 39 | JPMORGAN CHASE & CO | 291 | 3,000 | 0.00% | ||
| 40 | BANK OF MONTREAL /CAN/ | 161 | 2,000 | 0.00% | ||
| 41 | MYCIO WEALTH PARTNERS, LLC | 28 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
