| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 6,554,967 | 97,538,000 | 35.33% | ||
| 2 | BLACKROCK ADVISORS LLC | 2,863,927 | 42,615,000 | 15.44% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 2,019,748 | 30,054,000 | 10.89% | ||
| 4 | JPMORGAN CHASE & CO | 1,104,481 | 16,435,000 | 5.95% | ||
| 5 | BlackRock Group LTD | 995,480 | 14,813,000 | 5.37% | ||
| 6 | SECTORAL ASSET MANAGEMENT INC | 929,765 | 13,835,000 | 5.01% | ||
| 7 | Camber Capital Management LP | 500,000 | 7,440,000 | 2.70% | ||
| 8 | ORBIMED ADVISORS LLC | 456,666 | 6,795,000 | 2.46% | ||
| 9 | Rock Springs Capital Management LP | 400,000 | 5,952,000 | 2.16% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 305,092 | 4,540,000 | 1.64% | ||
| 11 | BlackRock Investment Management, LLC | 286,106 | 4,257,000 | 1.54% | ||
| 12 | LAZARD ASSET MANAGEMENT LLC | 205,550 | 3,058,000 | 1.11% | ||
| 13 | BlackRock Fund Advisors | 195,545 | 2,910,000 | 1.05% | ||
| 14 | Redmile Group, LLC | 181,224 | 2,563,000 | 0.93% | ||
| 15 | DEERFIELD MANAGEMENT COMPANY, L.P. | 166,666 | 2,480,000 | 0.90% | ||
| 16 | VANGUARD GROUP INC | 161,396 | 2,401,000 | 0.87% | ||
| 17 | PERCEPTIVE ADVISORS LLC | 299,583 | 2,306,000 | 0.84% | ||
| 18 | Alyeska Investment Group, L.P. | 132,140 | 1,966,000 | 0.71% | ||
| 19 | BlackRock Institutional Trust Company, N.A. | 122,844 | 1,828,000 | 0.66% | ||
| 20 | EMORY UNIVERSITY | 104,861 | 1,560,000 | 0.57% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 99,344 | 1,478,000 | 0.54% | ||
| 22 | NORTHERN TRUST CORP | 67,442 | 1,004,000 | 0.36% | ||
| 23 | PANAGORA ASSET MANAGEMENT INC | 59,118 | 880,000 | 0.32% | ||
| 24 | PICTET ASSET MANAGEMENT LTD | 82,800 | 827,000 | 0.30% | ||
| 25 | FRED ALGER MANAGEMENT, LLC | 52,400 | 780,000 | 0.28% | ||
| 26 | DEUTSCHE BANK AG\ | 50,990 | 757,000 | 0.27% | ||
| 27 | STATE STREET CORP | 49,924 | 742,000 | 0.27% | ||
| 28 | BlackRock Finance, Inc. | 41,396 | 616,000 | 0.22% | ||
| 29 | Bank of New York Mellon Corp | 29,146 | 433,000 | 0.16% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 26,421 | 393,000 | 0.14% | ||
| 31 | JENNISON ASSOCIATES LLC | 26,261 | 391,000 | 0.14% | ||
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 20,788 | 310,000 | 0.11% | ||
| 33 | UBS Group AG | 16,940 | 252,000 | 0.09% | ||
| 34 | PDT Partners, LLC | 16,432 | 245,000 | 0.09% | ||
| 35 | ClariVest Asset Management LLC | 15,100 | 224,000 | 0.08% | ||
| 36 | BANK OF AMERICA CORP /DE/ | 14,825 | 221,000 | 0.08% | ||
| 37 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 13,339 | 198,000 | 0.07% | ||
| 38 | CORRADO ADVISORS, LLC | 11,860 | 176,000 | 0.06% | ||
| 39 | GOLDMAN SACHS GROUP INC | 10,898 | 162,000 | 0.06% | ||
| 40 | TEACHERS ADVISORS, LLC | 10,409 | 155,000 | 0.06% | ||
| 41 | NEW YORK STATE COMMON RETIREMENT FUND | 7,649 | 114,000 | 0.04% | ||
| 42 | Nationwide Fund Advisors | 4,832 | 72,000 | 0.03% | ||
| 43 | US BANCORP \DE\ | 4,650 | 69,000 | 0.02% | ||
| 44 | AMERICAN INTERNATIONAL GROUP, INC. | 4,288 | 63,805 | 0.02% | ||
| 45 | STRS OHIO | 2,500 | 37,000 | 0.01% | ||
| 46 | MAZAMA CAPITAL MANAGEMENT INC | 1,747 | 26,000 | 0.01% | ||
| 47 | CITIGROUP INC | 1,449 | 21,000 | 0.01% | ||
| 48 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 1,044 | 16,000 | 0.01% | ||
| 49 | MORGAN STANLEY | 926 | 14,000 | 0.01% | ||
| 50 | BNP PARIBAS FINANCIAL MARKETS | 609 | 9,062 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
