| 1 |
BAKER BROS. ADVISORS LP |
6,554,967 |
57,422,000 |
30.95% |
|
|
| 2 |
WELLINGTON MANAGEMENT GROUP LLP |
3,240,117 |
28,383,000 |
15.30% |
|
|
| 3 |
Camber Capital Management LP |
2,442,122 |
21,393,000 |
11.53% |
|
|
| 4 |
BLACKROCK ADVISORS LLC |
2,191,392 |
19,197,000 |
10.35% |
|
|
| 5 |
VANGUARD GROUP INC |
915,529 |
8,020,000 |
4.32% |
|
|
| 6 |
Rock Springs Capital Management LP |
890,000 |
7,796,000 |
4.20% |
|
|
| 7 |
BlackRock Group LTD |
831,484 |
7,284,000 |
3.93% |
|
|
| 8 |
BlackRock Fund Advisors |
631,496 |
5,532,000 |
2.98% |
|
|
| 9 |
Redmile Group, LLC |
510,369 |
4,471,000 |
2.41% |
|
|
| 10 |
ORBIMED ADVISORS LLC |
456,666 |
4,000,000 |
2.16% |
|
|
| 11 |
BlackRock Institutional Trust Company, N.A. |
353,972 |
3,101,000 |
1.67% |
|
|
| 12 |
BlackRock Investment Management, LLC |
353,946 |
3,101,000 |
1.67% |
|
|
| 13 |
STATE STREET CORP |
309,497 |
2,712,000 |
1.46% |
|
|
| 14 |
NORTHERN TRUST CORP |
229,642 |
2,012,000 |
1.08% |
|
|
| 15 |
MILLENNIUM MANAGEMENT LLC |
217,188 |
1,903,000 |
1.03% |
|
|
| 16 |
ROYCE & ASSOCIATES LP |
156,412 |
1,370,000 |
0.74% |
|
|
| 17 |
GEODE CAPITAL MANAGEMENT, LLC |
148,836 |
1,303,000 |
0.70% |
|
|
| 18 |
HighTower Advisors, LLC |
95,742 |
840,000 |
0.45% |
|
|
| 19 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
77,919 |
683,000 |
0.37% |
|
|
| 20 |
DEUTSCHE BANK AG\ |
74,360 |
650,000 |
0.35% |
|
|
| 21 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
66,467 |
582,000 |
0.31% |
|
|
| 22 |
Bank of New York Mellon Corp |
64,269 |
563,000 |
0.30% |
|
|
| 23 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
48,009 |
421,000 |
0.23% |
|
|
| 24 |
Polar Capital LLP |
47,500 |
416,000 |
0.22% |
|
|
| 25 |
TEACHERS ADVISORS, LLC |
35,825 |
314,000 |
0.17% |
|
|
| 26 |
BlackRock Finance, Inc. |
33,064 |
290,000 |
0.16% |
|
|
| 27 |
GOLDMAN SACHS GROUP INC |
29,222 |
256,000 |
0.14% |
|
|
| 28 |
NEW YORK STATE COMMON RETIREMENT FUND |
23,500 |
206,000 |
0.11% |
|
|
| 29 |
RHUMBLINE ADVISERS |
19,009 |
167,000 |
0.09% |
|
|
| 30 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
17,271 |
152,000 |
0.08% |
|
|
| 31 |
Nationwide Fund Advisors |
14,134 |
124,000 |
0.07% |
|
|
| 32 |
AMERICAN INTERNATIONAL GROUP, INC. |
13,118 |
114,914 |
0.06% |
|
|
| 33 |
CREDIT SUISSE AG/ |
12,528 |
110,000 |
0.06% |
|
|
| 34 |
SG Americas Securities, LLC |
11,989 |
105,000 |
0.06% |
|
|
| 35 |
VOYA INVESTMENT MANAGEMENT LLC |
11,203 |
98,000 |
0.05% |
|
|
| 36 |
DIMENSIONAL FUND ADVISORS LP |
10,735 |
94,000 |
0.05% |
|
|
| 37 |
Verity Asset Management, Inc. |
10,505 |
92,000 |
0.05% |
|
|
| 38 |
MORGAN STANLEY |
9,802 |
86,000 |
0.05% |
|
|
| 39 |
WELLS FARGO & COMPANY/MN |
6,632 |
58,000 |
0.03% |
|
|
| 40 |
Legal & General Group Plc |
4,120 |
35,000 |
0.02% |
|
|
| 41 |
UBS Group AG |
3,392 |
30,000 |
0.02% |
|
|
| 42 |
BANK OF AMERICA CORP /DE/ |
1,691 |
15,000 |
0.01% |
|
|
| 43 |
BNP PARIBAS FINANCIAL MARKETS |
1,692 |
14,822 |
0.01% |
|
|
| 44 |
CITIGROUP INC |
977 |
9,000 |
0.00% |
|
|
| 45 |
TRUST CO OF VERMONT |
400 |
4,000 |
0.00% |
|
|
| 46 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
453 |
4,000 |
0.00% |
|
|
| 47 |
CUTLER GROUP LLC / CA |
400 |
3,000 |
0.00% |
|
|
| 48 |
CUTLER GROUP LLC / CA |
2,600 |
2,000 |
0.00% |
Put |
|
| 49 |
SIMPLEX TRADING, LLC |
197 |
1,000 |
0.00% |
|
|
| 50 |
BANK OF MONTREAL /CAN/ |
161 |
1,000 |
0.00% |
|
|
