| 1 |
BAKER BROS. ADVISORS LP |
6,554,967 |
47,327,000 |
33.62% |
|
|
| 2 |
BLACKROCK ADVISORS LLC |
2,863,947 |
20,678,000 |
14.69% |
|
|
| 3 |
WELLINGTON MANAGEMENT GROUP LLP |
2,770,975 |
20,006,000 |
14.21% |
|
|
| 4 |
BlackRock Group LTD |
995,480 |
7,187,000 |
5.10% |
|
|
| 5 |
Camber Capital Management LP |
894,014 |
6,455,000 |
4.58% |
|
|
| 6 |
Redmile Group, LLC |
660,129 |
4,766,000 |
3.39% |
|
|
| 7 |
JPMORGAN CHASE & CO |
656,115 |
4,738,000 |
3.37% |
|
|
| 8 |
VANGUARD GROUP INC |
552,704 |
3,990,000 |
2.83% |
|
|
| 9 |
Rock Springs Capital Management LP |
510,000 |
3,682,000 |
2.62% |
|
|
| 10 |
ORBIMED ADVISORS LLC |
456,666 |
3,297,000 |
2.34% |
|
|
| 11 |
MILLENNIUM MANAGEMENT LLC |
456,425 |
3,295,000 |
2.34% |
|
|
| 12 |
BlackRock Investment Management, LLC |
290,913 |
2,100,000 |
1.49% |
|
|
| 13 |
PERCEPTIVE ADVISORS LLC |
251,666 |
1,817,000 |
1.29% |
|
|
| 14 |
BlackRock Institutional Trust Company, N.A. |
200,030 |
1,444,000 |
1.03% |
|
|
| 15 |
BlackRock Fund Advisors |
193,281 |
1,395,000 |
0.99% |
|
|
| 16 |
EMORY UNIVERSITY |
173,743 |
1,254,000 |
0.89% |
|
|
| 17 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
166,666 |
1,203,000 |
0.85% |
|
|
| 18 |
Alyeska Investment Group, L.P. |
132,902 |
960,000 |
0.68% |
|
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
87,204 |
629,000 |
0.45% |
|
|
| 20 |
MORGAN STANLEY |
81,685 |
590,000 |
0.42% |
|
|
| 21 |
NORTHERN TRUST CORP |
76,651 |
554,000 |
0.39% |
|
|
| 22 |
DEUTSCHE BANK AG\ |
66,770 |
481,000 |
0.34% |
|
|
| 23 |
STATE STREET CORP |
50,194 |
361,000 |
0.26% |
|
|
| 24 |
FRED ALGER MANAGEMENT, LLC |
40,400 |
292,000 |
0.21% |
|
|
| 25 |
BlackRock Finance, Inc. |
34,474 |
249,000 |
0.18% |
|
|
| 26 |
TFS CAPITAL LLC |
34,044 |
246,000 |
0.17% |
|
|
| 27 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
26,421 |
191,000 |
0.14% |
|
|
| 28 |
JENNISON ASSOCIATES LLC |
26,344 |
190,000 |
0.13% |
|
|
| 29 |
Bank of New York Mellon Corp |
24,783 |
179,000 |
0.13% |
|
|
| 30 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
21,922 |
159,000 |
0.11% |
|
|
| 31 |
BANK OF AMERICA CORP /DE/ |
19,970 |
144,000 |
0.10% |
|
|
| 32 |
A.R.T. Advisors, LLC |
19,968 |
144,000 |
0.10% |
|
|
| 33 |
Verity Asset Management, Inc. |
16,922 |
122,000 |
0.09% |
|
|
| 34 |
ClariVest Asset Management LLC |
15,200 |
110,000 |
0.08% |
|
|
| 35 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
13,339 |
96,000 |
0.07% |
|
|
| 36 |
LPL Financial LLC |
12,500 |
92,000 |
0.07% |
|
|
| 37 |
UBS Group AG |
10,611 |
76,000 |
0.05% |
|
|
| 38 |
TEACHERS ADVISORS, LLC |
10,409 |
75,000 |
0.05% |
|
|
| 39 |
PANAGORA ASSET MANAGEMENT INC |
9,645 |
70,000 |
0.05% |
|
|
| 40 |
NEW YORK STATE COMMON RETIREMENT FUND |
6,700 |
48,000 |
0.03% |
|
|
| 41 |
Nationwide Fund Advisors |
4,832 |
35,000 |
0.02% |
|
|
| 42 |
AMERICAN INTERNATIONAL GROUP, INC. |
4,293 |
31,000 |
0.02% |
|
|
| 43 |
BNP PARIBAS FINANCIAL MARKETS |
1,911 |
13,797 |
0.01% |
|
|
| 44 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
1,044 |
8,000 |
0.01% |
|
|
| 45 |
WELLS FARGO & COMPANY/MN |
530 |
4,000 |
0.00% |
|
|
| 46 |
ROYAL BANK OF CANADA |
447 |
3,000 |
0.00% |
|
|
| 47 |
TRUST CO OF VERMONT |
400 |
3,000 |
0.00% |
|
|
| 48 |
CITIGROUP INC |
1 |
0 |
0.00% |
|
|
| 49 |
MYCIO WEALTH PARTNERS, LLC |
28 |
0 |
0.00% |
|
|
| 50 |
STRS OHIO |
0 |
0 |
0.00% |
|
|
