| 1 |
BAKER BROS. ADVISORS LP |
6,554,967 |
53,816,000 |
32.85% |
|
|
| 2 |
WELLINGTON MANAGEMENT GROUP LLP |
3,569,778 |
29,308,000 |
17.89% |
|
|
| 3 |
BLACKROCK ADVISORS LLC |
2,473,914 |
20,311,000 |
12.40% |
|
|
| 4 |
Camber Capital Management LP |
2,024,943 |
16,625,000 |
10.15% |
|
|
| 5 |
BlackRock Group LTD |
999,129 |
8,203,000 |
5.01% |
|
|
| 6 |
Redmile Group, LLC |
660,129 |
5,420,000 |
3.31% |
|
|
| 7 |
Rock Springs Capital Management LP |
622,900 |
5,114,000 |
3.12% |
|
|
| 8 |
VANGUARD GROUP INC |
572,981 |
4,704,000 |
2.87% |
|
|
| 9 |
ORBIMED ADVISORS LLC |
456,666 |
3,749,000 |
2.29% |
|
|
| 10 |
BlackRock Investment Management, LLC |
297,639 |
2,444,000 |
1.49% |
|
|
| 11 |
CASDIN CAPITAL, LLC |
250,000 |
2,053,000 |
1.25% |
|
|
| 12 |
BlackRock Institutional Trust Company, N.A. |
202,194 |
1,660,000 |
1.01% |
|
|
| 13 |
BlackRock Fund Advisors |
198,710 |
1,631,000 |
1.00% |
|
|
| 14 |
ROYCE & ASSOCIATES LP |
144,936 |
1,190,000 |
0.73% |
|
|
| 15 |
PERCEPTIVE ADVISORS LLC |
143,366 |
1,177,000 |
0.72% |
|
|
| 16 |
DEUTSCHE BANK AG\ |
88,142 |
721,000 |
0.44% |
|
|
| 17 |
GEODE CAPITAL MANAGEMENT, LLC |
81,655 |
670,000 |
0.41% |
|
|
| 18 |
NORTHERN TRUST CORP |
76,665 |
629,000 |
0.38% |
|
|
| 19 |
MILLENNIUM MANAGEMENT LLC |
64,727 |
531,000 |
0.32% |
|
|
| 20 |
STATE STREET CORP |
54,594 |
447,000 |
0.27% |
|
|
| 21 |
TFS CAPITAL LLC |
51,190 |
420,000 |
0.26% |
|
|
| 22 |
LPL Financial LLC |
45,000 |
336,000 |
0.21% |
|
|
| 23 |
BlackRock Finance, Inc. |
35,776 |
294,000 |
0.18% |
|
|
| 24 |
RENAISSANCE TECHNOLOGIES LLC |
34,190 |
281,000 |
0.17% |
|
|
| 25 |
A.R.T. Advisors, LLC |
32,368 |
265,000 |
0.16% |
|
|
| 26 |
JENNISON ASSOCIATES LLC |
26,407 |
217,000 |
0.13% |
|
|
| 27 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
26,421 |
217,000 |
0.13% |
|
|
| 28 |
CITADEL ADVISORS LLC |
26,129 |
214,000 |
0.13% |
|
|
| 29 |
Bank of New York Mellon Corp |
25,026 |
205,000 |
0.13% |
|
|
| 30 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
22,377 |
184,000 |
0.11% |
|
|
| 31 |
BANK OF AMERICA CORP /DE/ |
20,121 |
165,000 |
0.10% |
|
|
| 32 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
13,539 |
111,000 |
0.07% |
|
|
| 33 |
Verity Asset Management, Inc. |
12,571 |
103,000 |
0.06% |
|
|
| 34 |
MORGAN STANLEY |
12,143 |
100,000 |
0.06% |
|
|
| 35 |
TEACHERS ADVISORS, LLC |
10,409 |
85,000 |
0.05% |
|
|
| 36 |
NEW YORK STATE COMMON RETIREMENT FUND |
6,700 |
55,000 |
0.03% |
|
|
| 37 |
Nationwide Fund Advisors |
4,832 |
40,000 |
0.02% |
|
|
| 38 |
AMERICAN INTERNATIONAL GROUP, INC. |
4,285 |
35,000 |
0.02% |
|
|
| 39 |
UBS Group AG |
2,592 |
21,000 |
0.01% |
|
|
| 40 |
CITIGROUP INC |
2,247 |
18,000 |
0.01% |
|
|
| 41 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
1,044 |
9,000 |
0.01% |
|
|
| 42 |
BNP PARIBAS FINANCIAL MARKETS |
932 |
7,652 |
0.00% |
|
|
| 43 |
BlackRock Japan Co. Ltd |
759 |
6,000 |
0.00% |
|
|
| 44 |
WELLS FARGO & COMPANY/MN |
523 |
4,000 |
0.00% |
|
|
| 45 |
Tower Research Capital LLC (TRC) |
402 |
3,000 |
0.00% |
|
|
| 46 |
TRUST CO OF VERMONT |
400 |
3,000 |
0.00% |
|
|
| 47 |
BANK OF MONTREAL /CAN/ |
161 |
1,000 |
0.00% |
|
|
| 48 |
MYCIO WEALTH PARTNERS, LLC |
28 |
0 |
0.00% |
|
|
