| 1 |
BAKER BROS. ADVISORS LP |
6,554,967 |
48,441,000 |
30.42% |
|
|
| 2 |
WELLINGTON MANAGEMENT GROUP LLP |
3,557,546 |
26,291,000 |
16.51% |
|
|
| 3 |
Camber Capital Management LP |
2,746,622 |
20,298,000 |
12.75% |
|
|
| 4 |
BLACKROCK ADVISORS LLC |
2,367,033 |
17,492,000 |
10.98% |
|
|
| 5 |
BlackRock Group LTD |
875,670 |
6,471,000 |
4.06% |
|
|
| 6 |
Rock Springs Capital Management LP |
858,380 |
6,343,000 |
3.98% |
|
|
| 7 |
VANGUARD GROUP INC |
636,857 |
4,706,000 |
2.95% |
|
|
| 8 |
BlackRock Fund Advisors |
583,714 |
4,314,000 |
2.71% |
|
|
| 9 |
Redmile Group, LLC |
544,939 |
4,027,000 |
2.53% |
|
|
| 10 |
ORBIMED ADVISORS LLC |
456,666 |
3,375,000 |
2.12% |
|
|
| 11 |
BlackRock Investment Management, LLC |
354,076 |
2,617,000 |
1.64% |
|
|
| 12 |
BlackRock Institutional Trust Company, N.A. |
315,984 |
2,335,000 |
1.47% |
|
|
| 13 |
STATE STREET CORP |
272,171 |
2,010,000 |
1.26% |
|
|
| 14 |
MILLENNIUM MANAGEMENT LLC |
260,250 |
1,923,000 |
1.21% |
|
|
| 15 |
NORTHERN TRUST CORP |
219,572 |
1,622,000 |
1.02% |
|
|
| 16 |
ROYCE & ASSOCIATES LP |
156,412 |
1,156,000 |
0.73% |
|
|
| 17 |
GEODE CAPITAL MANAGEMENT, LLC |
92,931 |
686,000 |
0.43% |
|
|
| 18 |
DEUTSCHE BANK AG\ |
80,937 |
597,000 |
0.37% |
|
|
| 19 |
HighTower Advisors, LLC |
77,164 |
565,000 |
0.35% |
|
|
| 20 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
66,467 |
491,000 |
0.31% |
|
|
| 21 |
Bank of New York Mellon Corp |
63,083 |
466,000 |
0.29% |
|
|
| 22 |
Polar Capital LLP |
55,000 |
406,000 |
0.25% |
|
|
| 23 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
47,709 |
353,000 |
0.22% |
|
|
| 24 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
44,528 |
330,000 |
0.21% |
|
|
| 25 |
TEACHERS ADVISORS, LLC |
35,825 |
265,000 |
0.17% |
|
|
| 26 |
BlackRock Finance, Inc. |
32,656 |
242,000 |
0.15% |
|
|
| 27 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
27,946 |
207,000 |
0.13% |
|
|
| 28 |
NEW YORK STATE COMMON RETIREMENT FUND |
23,500 |
174,000 |
0.11% |
|
|
| 29 |
METROPOLITAN LIFE INSURANCE CO/NY |
19,278 |
142,000 |
0.09% |
|
|
| 30 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
17,722 |
131,000 |
0.08% |
|
|
| 31 |
RHUMBLINE ADVISERS |
16,469 |
122,000 |
0.08% |
|
|
| 32 |
Nationwide Fund Advisors |
14,134 |
104,000 |
0.07% |
|
|
| 33 |
AMERICAN INTERNATIONAL GROUP, INC. |
13,098 |
96,794 |
0.06% |
|
|
| 34 |
Virtu KCG Holdings LLC |
12,217 |
90,000 |
0.06% |
|
|
| 35 |
VOYA INVESTMENT MANAGEMENT LLC |
11,203 |
83,000 |
0.05% |
|
|
| 36 |
CREDIT SUISSE AG/ |
10,689 |
79,000 |
0.05% |
|
|
| 37 |
DIMENSIONAL FUND ADVISORS LP |
10,735 |
79,000 |
0.05% |
|
|
| 38 |
MORGAN STANLEY |
4,797 |
35,000 |
0.02% |
|
|
| 39 |
Legal & General Group Plc |
4,120 |
30,000 |
0.02% |
|
|
| 40 |
WELLS FARGO & COMPANY/MN |
2,832 |
21,000 |
0.01% |
|
|
| 41 |
CITIGROUP INC |
2,000 |
15,000 |
0.01% |
|
|
| 42 |
BANK OF AMERICA CORP /DE/ |
1,555 |
12,000 |
0.01% |
|
|
| 43 |
BNP PARIBAS FINANCIAL MARKETS |
894 |
6,607 |
0.00% |
|
|
| 44 |
UBS Group AG |
400 |
3,000 |
0.00% |
|
|
| 45 |
TRUST CO OF VERMONT |
400 |
3,000 |
0.00% |
|
|
| 46 |
JPMORGAN CHASE & CO |
399 |
3,000 |
0.00% |
|
|
| 47 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
453 |
3,000 |
0.00% |
|
|
| 48 |
BANK OF MONTREAL /CAN/ |
161 |
1,000 |
0.00% |
|
|
| 49 |
MYCIO WEALTH PARTNERS, LLC |
28 |
0 |
0.00% |
|
|
