| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 6,554,967 | 109,861,000 | 36.42% | ||
| 2 | BLACKROCK ADVISORS LLC | 2,862,672 | 47,978,000 | 15.91% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 1,978,858 | 32,999,000 | 10.94% | ||
| 4 | BlackRock Group LTD | 1,025,225 | 17,182,000 | 5.70% | ||
| 5 | JPMORGAN CHASE & CO | 874,701 | 14,660,000 | 4.86% | ||
| 6 | SECTORAL ASSET MANAGEMENT INC | 874,391 | 14,655,000 | 4.86% | ||
| 7 | Redmile Group, LLC | 785,131 | 10,946,000 | 3.63% | ||
| 8 | ORBIMED ADVISORS LLC | 456,666 | 7,654,000 | 2.54% | ||
| 9 | Camber Capital Management LP | 400,000 | 6,704,000 | 2.22% | ||
| 10 | BlackRock Investment Management, LLC | 274,499 | 4,601,000 | 1.53% | ||
| 11 | LAZARD ASSET MANAGEMENT LLC | 272,419 | 4,565,000 | 1.51% | ||
| 12 | BlackRock Fund Advisors | 202,171 | 3,388,000 | 1.12% | ||
| 13 | DEERFIELD MANAGEMENT COMPANY, L.P. | 166,666 | 2,793,000 | 0.93% | ||
| 14 | PERCEPTIVE ADVISORS LLC | 165,000 | 2,765,000 | 0.92% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 133,612 | 2,239,000 | 0.74% | ||
| 16 | Alyeska Investment Group, L.P. | 130,000 | 2,179,000 | 0.72% | ||
| 17 | Rock Springs Capital Management LP | 125,000 | 2,095,000 | 0.69% | ||
| 18 | MILLENNIUM MANAGEMENT LLC | 120,141 | 2,014,000 | 0.67% | ||
| 19 | FRANKLIN RESOURCES INC | 104,800 | 1,756,000 | 0.58% | ||
| 20 | CADIAN CAPITAL MANAGEMENT, LP | 65,000 | 1,089,000 | 0.36% | ||
| 21 | PICTET ASSET MANAGEMENT LTD | 97,400 | 1,067,000 | 0.35% | ||
| 22 | PANAGORA ASSET MANAGEMENT INC | 49,663 | 832,000 | 0.28% | ||
| 23 | MORGAN STANLEY | 42,548 | 713,000 | 0.24% | ||
| 24 | BlackRock Finance, Inc. | 41,396 | 693,000 | 0.23% | ||
| 25 | MONASHEE INVESTMENT MANAGEMENT LLC | 32,232 | 540,000 | 0.18% | ||
| 26 | VANGUARD GROUP INC | 30,452 | 511,000 | 0.17% | ||
| 27 | D. E. Shaw & Co., Inc. | 28,413 | 476,000 | 0.16% | ||
| 28 | Weiss Multi-Strategy Advisers LLC | 27,730 | 465,000 | 0.15% | ||
| 29 | JENNISON ASSOCIATES LLC | 26,182 | 439,000 | 0.15% | ||
| 30 | Allianz Asset Management GmbH | 24,650 | 413,000 | 0.14% | ||
| 31 | CREDIT SUISSE AG/ | 22,020 | 370,000 | 0.12% | ||
| 32 | Bank of New York Mellon Corp | 20,118 | 337,000 | 0.11% | ||
| 33 | STATE STREET CORP | 19,124 | 320,000 | 0.11% | ||
| 34 | DEUTSCHE BANK AG\ | 18,400 | 308,000 | 0.10% | ||
| 35 | NORTHERN TRUST CORP | 17,840 | 299,000 | 0.10% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 16,200 | 272,000 | 0.09% | ||
| 37 | Laurion Capital Management LP | 15,300 | 256,000 | 0.08% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 14,300 | 240,000 | 0.08% | ||
| 39 | Cubist Systematic Strategies, LLC | 13,823 | 232,000 | 0.08% | ||
| 40 | Virtu KCG Holdings LLC | 13,390 | 224,000 | 0.07% | ||
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 13,300 | 223,000 | 0.07% | ||
| 42 | TEACHERS ADVISORS, LLC | 7,081 | 119,000 | 0.04% | ||
| 43 | MAZAMA CAPITAL MANAGEMENT INC | 2,872 | 48,000 | 0.02% | ||
| 44 | STRS OHIO | 2,500 | 41,000 | 0.01% | ||
| 45 | Tower Research Capital LLC (TRC) | 2,244 | 38,000 | 0.01% | ||
| 46 | Nationwide Fund Advisors | 1,990 | 33,000 | 0.01% | ||
| 47 | WELLS FARGO & COMPANY/MN | 300 | 5,000 | 0.00% | ||
| 48 | UBS Group AG | 280 | 5,000 | 0.00% | ||
| 49 | ROYAL BANK OF CANADA | 200 | 3,000 | 0.00% | ||
| 50 | BNP PARIBAS FINANCIAL MARKETS | 173 | 2,899 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
