| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 7,288,300 | 57,869,000 | 26.98% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 3,949,127 | 31,356,000 | 14.62% | ||
| 3 | Camber Capital Management LP | 2,398,123 | 19,041,000 | 8.88% | ||
| 4 | BLACKROCK ADVISORS LLC | 2,051,489 | 16,289,000 | 7.59% | ||
| 5 | Rock Springs Capital Management LP | 1,200,000 | 9,528,000 | 4.44% | ||
| 6 | VANGUARD GROUP INC | 1,098,491 | 8,722,000 | 4.07% | ||
| 7 | Redmile Group, LLC | 1,065,002 | 8,456,000 | 3.94% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 819,202 | 6,504,000 | 3.03% | ||
| 9 | BlackRock Fund Advisors | 780,737 | 6,199,000 | 2.89% | ||
| 10 | BlackRock Group LTD | 750,023 | 5,955,000 | 2.78% | ||
| 11 | ARK INVESTMENT MANAGEMENT LLC | 666,570 | 5,293,000 | 2.47% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 561,848 | 4,461,000 | 2.08% | ||
| 13 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 500,000 | 3,970,000 | 1.85% | ||
| 14 | PERCEPTIVE ADVISORS LLC | 500,000 | 3,970,000 | 1.85% | ||
| 15 | ORBIMED ADVISORS LLC | 456,666 | 3,626,000 | 1.69% | ||
| 16 | BlackRock Investment Management, LLC | 352,682 | 2,800,000 | 1.31% | ||
| 17 | STATE STREET CORP | 338,514 | 2,688,000 | 1.25% | ||
| 18 | NORTHERN TRUST CORP | 304,668 | 2,419,000 | 1.13% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 228,470 | 1,814,000 | 0.85% | ||
| 20 | HighTower Advisors, LLC | 225,957 | 1,796,000 | 0.84% | ||
| 21 | ROYCE & ASSOCIATES LP | 156,412 | 1,242,000 | 0.58% | ||
| 22 | DEUTSCHE BANK AG\ | 119,947 | 951,000 | 0.44% | ||
| 23 | RENAISSANCE TECHNOLOGIES LLC | 110,700 | 879,000 | 0.41% | ||
| 24 | Bank of New York Mellon Corp | 92,653 | 736,000 | 0.34% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 91,510 | 727,000 | 0.34% | ||
| 26 | MORGAN STANLEY | 86,523 | 687,000 | 0.32% | ||
| 27 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 82,693 | 657,000 | 0.31% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 60,169 | 478,000 | 0.22% | ||
| 29 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 58,209 | 462,000 | 0.22% | ||
| 30 | CITADEL ADVISORS LLC | 52,264 | 415,000 | 0.19% | ||
| 31 | Squarepoint Ops LLC | 47,000 | 373,000 | 0.17% | ||
| 32 | TEACHERS ADVISORS, LLC | 42,372 | 336,000 | 0.16% | ||
| 33 | JPMORGAN CHASE & CO | 40,410 | 321,000 | 0.15% | ||
| 34 | D. E. Shaw & Co., Inc. | 38,545 | 306,000 | 0.14% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 35,800 | 284,000 | 0.13% | Put | |
| 36 | SIMPLEX TRADING, LLC | 32,931 | 261,000 | 0.12% | ||
| 37 | BlackRock Finance, Inc. | 31,756 | 252,000 | 0.12% | ||
| 38 | WOLVERINE TRADING LP /BD | 27,411 | 218,000 | 0.10% | ||
| 39 | RHUMBLINE ADVISERS | 25,136 | 200,000 | 0.09% | ||
| 40 | NEW YORK STATE COMMON RETIREMENT FUND | 23,500 | 187,000 | 0.09% | ||
| 41 | WELLS FARGO & COMPANY/MN | 23,244 | 184,000 | 0.09% | ||
| 42 | GOLDMAN SACHS GROUP INC | 21,035 | 167,000 | 0.08% | ||
| 43 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 20,491 | 163,000 | 0.08% | ||
| 44 | CREDIT SUISSE AG/ | 20,484 | 163,000 | 0.08% | ||
| 45 | Cubist Systematic Strategies, LLC | 18,117 | 144,000 | 0.07% | ||
| 46 | LPL Financial LLC | 14,250 | 125,000 | 0.06% | ||
| 47 | Nationwide Fund Advisors | 14,134 | 112,000 | 0.05% | ||
| 48 | TFS CAPITAL LLC | 13,589 | 108,000 | 0.05% | ||
| 49 | AMERICAN INTERNATIONAL GROUP, INC. | 13,084 | 104,000 | 0.05% | ||
| 50 | VOYA INVESTMENT MANAGEMENT LLC | 11,203 | 89,000 | 0.04% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
